Results 261 to 270 of about 812,587 (357)

Cobalt‐Based Catalyst Integration Into a Hierarchically Ordered Macro‐Meso‐microporous Carbon Cathode for High‐performance Aqueous Zn‐Sulfur Batteries

open access: yesAdvanced Science, EarlyView.
The ordered macro‐microporous carbon material (OM‐PC) with integration of Co3ZnC/Co catalyst is derived from a Co‐doped ZIF‐8 via in situ growth within the interstitial spaces of a self‐assembled polystyrene monolith. The hierarchical 3D architecture facilitates Zn2⁺ diffusion, and the Co3ZnC/Co catalyst significantly improves the affinity of the ...
Liangzhen Liu   +6 more
wiley   +1 more source

High exposure variance enables candidate biomarker detection in a small EWAS of methylmercury-exposed Peruvian adults. [PDF]

open access: yesBMC Genom Data
Weinhouse C   +8 more
europepmc   +1 more source

Geometrically Encoded Positioning of Introns, Intergenic Segments, and Exons in the Human Genome

open access: yesAdvanced Science, EarlyView.
This study introduces a new hypothesis: exons, introns, and intergenic segments are non‐random projections of the functional layers of 3D structure of chromatin packing domains. Evidence is presented that this “geometric code” may encode volumetric structure, reconciling epigenetic patterns, correlates with oncogenic mutations, acting as a potential ...
Luay M. Almassalha   +11 more
wiley   +1 more source

Development of Age‐ and Sex‐Specific Metabolomics‐Based Biological Ageing Clocks for 10‐Year Mortality Prediction

open access: yesAdvanced Science, EarlyView.
Metabolomics‐based ageing clocks developed using blood biomarkers from over 215 000 European adults, improved the prediction of 10‐year all‐cause mortality compared to traditional models. Biological age acceleration is associated with higher mortality risk, as each additional year of metabolic age corresponded to at least 8% increased risk. These tools
Lei Peng   +4 more
wiley   +1 more source

From crystal structure to 3D printing to virtual reality in the classroom. [PDF]

open access: yesActa Crystallogr E Crystallogr Commun
Dogutan DK, Sullivan MG, Wolfskill C.
europepmc   +1 more source

CSN6 Promotes Pancreatic Cancer Progression and Gemcitabine Resistance via Antagonizing DCAF1‐Mediated Ubiquitination of NPM1

open access: yesAdvanced Science, EarlyView.
COP9 signalosome subunit 6 (CSN6) promotes the auto‐ubiquitination and degradation of DDB1‐CUL4 associated factor 1 (DCAF1), thereby antagonizing DCAF1‐mediated ubiquitination of Nucleophosmin (NPM1). This stabilization of NPM1 enhances the ribosome biogenesis process and the translation of specific gemcitabine‐resistance proteins, ultimately driving ...
Yijing Zhang   +14 more
wiley   +1 more source

PDZK1 Protects Against RPE Senescence by Targeting the 14‐3‐3ε‐mTOR Axis to Attenuate Early Diabetic Retinopathy

open access: yesAdvanced Science, EarlyView.
PDZK1 down‐regulation couples high‐glucose stress to RPE senescence via a PDZK1–14‐3‐3ε–mTOR axis. Restoring PDZK1 or clearing senescent cells rescues retinal homeostasis and mitigates early diabetic retinopathy (DR). This study provides direct evidence linking RPE cell senescence to DR pathogenesis and reveals a promising therapeutic strategy for DR ...
Jian Zhao   +6 more
wiley   +1 more source

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