Results 261 to 270 of about 452,480 (353)

Long Term High‐Salt Diet Induces Cognitive Impairments via Down‐Regulating SHANK1

open access: yesAdvanced Science, EarlyView.
The study identifies a novel mechanistic link between long‐term HS diet and cognitive impairment, wherein PKA/CREB axis inactivation leads to SHANK1 reduction, synaptic damage, and cognitive deficits. Abstract High‐salt (HS) diet is an established risk factor for cognitive impairment, but the underlying mechanisms remain unclear.
Cuiping Guo   +10 more
wiley   +1 more source

Podocyte RIPK3 Deletion Improves Diabetic Kidney Disease by Attenuating NF‐κB p65 Driven Inflammation

open access: yesAdvanced Science, EarlyView.
Prevention and treatment of diabetic kidney disease (DKD) have become a major global public health challenge. This study shed new light on the underlying pathogenic mechanisms of podocyte injury in DKD and highlights the therapeutic potential of mitigating podocyte injury through inhibition of the RIPK3/NF‐κB p65‐mediated inflammatory response as a ...
Lu'an Li   +10 more
wiley   +1 more source

From Ancient Techniques to Modern Solutions: In Situ Synthesis of C‐S‐H for Sandstone Conservation

open access: yesAdvanced Science, EarlyView.
Herein, this work presents a paleo‐inspired approach to synthesizing and optimizing C‐S‐H‐based grouting mortars for conserving the sandstone of Beishan Grottoes, Dazu Rock Carvings, China. By achieving an optimal recipe compatible with natural sandstone, this work demonstrates the pivotal role of hydrogen bonding in the adhesion between C‐S‐H mortars ...
Mengjun Jia   +9 more
wiley   +1 more source

A Machine‐Learning Approach Identifies Rejuvenating Interventions in the Human Brain

open access: yesAdvanced Science, EarlyView.
Rising life expectancy increases the incidence of age‐related neurodegeneration. Reverting brain aging through effective rejuvenation strategies constitutes a promising strategy to counteract these disorders and restore brain function. This study uses a brain‐specific transcriptional aging clock to screen over 43 000 perturbation profiles, identifying ...
Guillem Santamaria   +5 more
wiley   +1 more source

<i>AsNAC</i> Genes: Response to High Mercury Concentrations in <i>Allium sativum</i> Seed Clove. [PDF]

open access: yesBioTech (Basel)
Mendoza-Almanza B   +6 more
europepmc   +1 more source

Electrocatalytic Hydrogen Oxidation by Defect‐Enriched CuW Nanoalloy Featuring Hydrogen Spillover Effect

open access: yesAdvanced Science, EarlyView.
The CuW nanoalloy is synthesized via electrodeposition, with the coexistence of Cu, W/WO3 enhancing hydrogen spillover and improving hydrogen oxidation. W/WO3 facilitates hydrogen adsorption, whereas Cu supports hydrogen spillover and oxidation catalysis.
Bingyan Xiong, Lisong Chen, Jianlin Shi
wiley   +1 more source

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