Results 31 to 40 of about 163,741 (266)
EvoGraphCoder: An Evolutionary Graph-Reasoning Framework for Self-Adaptive Software Engineering
IEEE AccessModern software evolves rapidly, accumulates architectural debt, and develops cross-module dependencies that complicate reliable maintenance. We present EvoGraphCoder, an evolutionary graph-reasoning framework for self-adaptive software engineering ...
Karthik Ramamurthy +2 more
doaj +1 more source
International Journal of Mining Science and Technology, 2018 Mercury emitted from direct combustion of high-mercury coal does great harm to the environment. To make good use of high-mercury coal, it is necessary to study the occurrence characteristics of mercury in coal and high-efficient methods of mercury ...
Guilin Zhang +4 more
doaj +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
When Less Is More
IEEE Access, 2019 Digitizing RF signals using few bit ADCs can provide system advantages in terms of reduced power dissipation, wider sampling bandwidth, and decreased demand for digital throughput. The diversity of established applications based on few bit ADCs, together
Christopher T. Rodenbeck +5 more
doaj +1 more source
FEBS Open Bio, EarlyView.TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose +9 more
wiley +1 more source
FEBS Open Bio, EarlyView.We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli +3 more
wiley +1 more source
In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols
FEBS Open Bio, EarlyView.Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton +6 more
wiley +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Environmental Mercury and Its Toxic Effects [PDF]
Journal of Preventive Medicine and Public Health, 2014 Mercury exists naturally and as a man-made contaminant. The release of processed mercury can lead to a progressive increase in the amount of atmospheric mercury, which enters the atmospheric-soil-water distribution cycles where it can remain in ...
Kevin M. Rice +4 more
doaj +1 more source