Results 31 to 40 of about 314,866 (307)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

A novel direct activator of AMPK inhibits prostate cancer growth by blocking lipogenesis

EMBO Molecular Medicine, 2014
5′AMP‐activated kinase (AMPK) constitutes a hub for cellular metabolic and growth control, thus representing an ideal therapeutic target for prostate cancers (PCas) characterized by increased lipogenesis and activation of mTORC1 pathway. However, whether
Giorgia Zadra, Cornelia Photopoulos, Svitlana Tyekucheva, Pedram Heidari, Qing Ping Weng, Giuseppe Fedele, Hong Liu, Natalia Scaglia, Carmen Priolo, Ewa Sicinska, Umar Mahmood, Sabina Signoretti, Neal Birnberg, Massimo Loda   +13 more
doaj   +1 more source

Summertime elemental mercury exchange of temperate grasslands on an ecosystem-scale [PDF]

, 2008
In order to estimate the air-surface mercury exchange of grasslands in temperate climate regions, fluxes of gaseous elemental mercury (GEM) were measured at two sites in Switzerland and one in Austria during summer 2006.
A. Hammerle, C. Alewell, Ammann, C., Fritsche, J., Ammann, Christof, Obrist, D., Zeeman, M., Hammerle, Albin, Obrist, Daniel, Alewell, Christine, C. Ammann, Fritsche, Johannes, Hammerle, A., D. Obrist, G. Wohlfahrt, Alewell, C., J. Fritsche, Zeeman, Matthias, M. Zeeman, Wohlfahrt, Georg, Wohlfahrt, G.   +20 more
core   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Comparison of Numerical Simulations of Propeller Open-Water Performance with Cavitation for High-Speed Planing Hulls

Journal of Marine Science and Engineering
Numerical simulations of an open-water propeller are performed using CFDShip-Iowa. The propeller, originally designed by Mercury Marine for a 21 feet high-speed planing hull, is scaled to match a 42 feet hull configuration. Three advance ratios (J = 0.8,
Sungtek Park, Zhaoyuan Wang, Frederick Stern, Andrew Gunderson, John Scherer   +4 more
doaj   +1 more source

Sensing Mercury for Biomedical and Environmental Monitoring

Sensors, 2009
Mercury is a very toxic element that is widely spread in the atmosphere, lithosphere, and surface water. Concentrated mercury poses serious problems to human health, as bioaccumulation of mercury within the brain and kidneys ultimately leads to ...
Julia Xiaojun Zhao, E. Michael Collins, Hanying Xu, Paul D. Selid, Marla Striped Face-Collins   +4 more
doaj   +1 more source

Mercury recovery from acidic mercury solution using electrodeposition

工程科学学报, 2020
Mercury, a heavy metal, can seriously harm human bodies and the environment due to its characteristics of high toxicity, biological enrichment, and long-range migration.
Zi-liang LI, Zhi-feng XU, Xi ZHANG, Miao-miao ZAN, Zhi-lou LIU   +4 more
doaj   +1 more source

The prevalence of inorganic mercury in human cells increases during aging but decreases in the very old

Scientific Reports, 2021
Successful aging is likely to involve both genetic and environmental factors, but environmental toxicants that accelerate aging are not known. Human exposure to mercury is common, and mercury has genotoxic, autoimmune, and free radical effects which ...
Roger Pamphlett
doaj   +1 more source

Environmental Impact of Anthropogenic Mercury Release in China

Chemical Engineering Transactions, 2021
There is increasing public concern regarding the potential risks posed by mercury and mercury compounds. Knowledge of the mercury emission and release inventory, and determination of the main factors that ameliorate the environmental impact of ...
Habuer, Takeshi Fujiwara, Masaki Takaoka   +2 more
doaj   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source