Results 111 to 120 of about 104,344 (309)
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Economic Analysis, 2017 My intention is to clarify the process of merging from the economic point of view, especially impact on financial results after the merger itself. Examine and analyze differences in financial results, measured by using various ratio indicators, market ...
Jakub Tej
doaj
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Analysis of Historical Waves of Mergers and Acquisitions Market
Экономика и управление, 2019 The presented study examines historical waves of merger and acquisition deals. Aim. The study analyzes historical waves of business amalgamation deals with the aim to identify factors that increased the number of deals occurring in certain historical ...
Denis A. Buyvolov
doaj
Le Parti des Paysans de Bessarabie et la rivalite entre Pantelimon Halippa et Ion Inculeţ [PDF]
Codrul Cosminului, 2011 L’effervescence du mouvement national en Bessarabie en 1917 a apporté en premier plan la question de l’organisation de la vie politique. Anterieurement il n’y avait pas des partis politiques proprement dits et en étant animés par le meme but, les leaders
Andrei Cemârtan
doaj
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Merger Clusters during Economic Booms [PDF]
Merger activity is intense during economic booms and subdued during recessions. This paper provides a non-financial explanation for this observable pattern.
Albert Banal-Estañol +3 more
core
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Betcha can’t acquire just one: merger programs and compensation [PDF]
This paper examines the evolution of merger programs, that is, repeated acquisitions by the same firm. Most acquisitions are made by firms with merger programs.
Richard J. Rosen
core