The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Innovation in EU merger control: walking the talk. Bruegel Policy Contribution 2012/04, February 2012 [PDF]
, 2012 European Union policymakers have in principle put innovation at the heart of competitiveness, in particular in the Europe 2020 strategy. But in merger control, assessments of the innovation effects of mergers are inadequate, even though mergers and ...
Veugelers, Reinhilde.
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
A Note on Competing Merger Simulation Models in Antitrust Cases: Can the Best Be Identified? [PDF]
Advanced economic instruments like simulation models are enjoying an increased popularity in practical antitrust. There is hope that they – being quantitative predictive economic evidence – can substitute for qualitative structural analysis and lead to ...
Oliver Budzinski
core
Threat or opportunity? acquisitions of minority shareholdings in the context of competition law, in light of the European Commission’s white paper: European Commission’s white paper: towards more effective EU merger control (COM (2014) 449 final) [PDF]
, 2015 Käsittelen Pro Gradu tutkielmassani vähemmistöosuuksien hankintoja Euroopan Komission Valkoisen Kirjan (COM (2014) 449 final) valossa. Valkoisen kirjan mukaisesti Komissio ehdottaa uutta kohdennettua avoimuusjärjestelmää, jonka avulla kilpailuhaittoja ...
Lindroos, Heikki
core
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Betcha can’t acquire just one: merger programs and compensation [PDF]
This paper examines the evolution of merger programs, that is, repeated acquisitions by the same firm. Most acquisitions are made by firms with merger programs.
Richard J. Rosen
core
New Observational Recipes for Measuring Dynamical States of Galaxy Clusters
The Astrophysical JournalDuring cluster assembly, a cluster’s virialization process leaves behind signatures that can provide information on its dynamical state. However, no clear consensus yet exists on the best way to achieve this.
Hyowon Kim +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Conglomerate mergers in digital ecosystems: EU merger control beyond foreclosure
Market and Competition Law ReviewOver the past two decades, large technology firms have evolved into complex digital ecosystems operating across multiple, interconnected markets. This transformation has been driven not only by internal innovation, but also by extensive merger and ...
Laura Zoboli
doaj +1 more source