Results 191 to 200 of about 59,175 (313)

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Physician mergers involve 38% of doctors, substantial health system participation, and frequent serial acquisition. [PDF]

Health Aff Sch
Deibler D, Hosken D, Koch T, Thomas M.
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

A prototype differential atom interferometer for fundamental physics. [PDF]

Nature
Baynham CFA, Hobson R, Buchmüller O, Evans D, Hawkins L, Iannizzotto Venezze L, Josset A, Lee D, Pasatembou E, Sauer BE, Tarbutt MR, Walker T, Ennis O, Chauhan U, Brzakalik A, Dey S, Hedges S, Stray B, Langlois M, Bongs K, Hird T, Lellouch S, Holynski M, Bostwick B, Chen J, Eyler Z, Gibson V, Harte TL, Hsu CC, Karzazi M, Lu C, Millward B, Mitchell J, Mouelle N, Panchumarthi B, Scheper J, Schneider U, Su X, Tang Y, Tkalčec K, Zeuner M, Zhang S, Zhi Y, Badurina L, Beniwal A, Blas D, Carlton J, Ellis J, McCabe C, Parish G, Govardhan DP, Vaskonen V, Bowcock T, Bridges K, Carroll A, Coleman J, Elertas G, Hindley S, Metelko C, Throssell H, Tinsley JN, Bentine E, Booth M, Bortoletto D, Callaghan N, Foot C, Gómez-Monedero C, Hughes K, James A, Leese T, Lowe A, March-Russell J, Sander J, Schelfhout J, Shipsey I, Weatherill D, Wood D, Balashov SN, Bason MG, Hussain K, Labiad H, Majewski P, Marchant AL, Newbold D, Pan Z, Tam Z, Thornton TC, Valenzuela T, van der Grinten MGD, Wilmut I, Clarke K, Vick A, AION Collaboration.   +92 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Lean integration: A blueprint for occupational health services transformation in healthcare mergers. [PDF]

Healthc Manage Forum
Kestenberg S, Patel RH, Tan AO, De Graeve DC, Dhar A, Dus T.   +5 more
europepmc   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Mergers and Acquisitions in Europe

This paper provides a comprehensive overview of the European takeover market.We characterize the main features of the domestic and cross-border corporate takeovers involving European companies in the period 1993-2001.We provide detailed and comparable ...
Martynova, M., Renneboog, L.D.R.
core  

Hospital Mergers, Hospital Choice, and Care Quality for Pregnant Enrollees in Medicaid.

JAMA Health Forum
Desai SM, Padmanabhan P, Glied S, Roberts ET.   +3 more
europepmc   +1 more source

Merging public elementary schools to reduce racial/ethnic segregation. [PDF]

PNAS Nexus
Landry M, Gillani N.
europepmc   +1 more source