Results 151 to 160 of about 32,971 (262)

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Financial market integration and the value of global diversification: evidence from US acquirers in cross-border mergers and acquisitions [PDF]

Using theories of internal capital markets, this paper examines the link between financial market integration and the value of global diversification.
Francis , Bill B, Sun , Xian, Hasan , Iftekhar   +2 more
core  

FUSÕES E AQUISIÇÕES DE EMPRESAS BRASILEIRAS: CRIAÇÃO DE VALOR E SINERGIAS OPERACIONAIS

RAE: Revista de Administração de Empresas, 2009
The objective of this article was to assess if mergers and acquisitions in Brazilian companies resulted in operating synergies and created value for shareholders.
Francisco Vidal Barbosa, Marcos Antônio de Camargos   +1 more
doaj  

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Banking Globalization: International Consolidation and Mergers in Banking [PDF]

This paper surveys recent literature on international mergers and acquisitions in banking. We focus on three main questions. First, what are the determinants of cross-border mergers of commercial banks?
Gayle L. DeLong, Claudia M. Buch
core  

Cost structure effects of horizontal airline mergers and acquisitions. [PDF]

Transp Policy (Oxf), 2020
Gudmundsson SV, Merkert R, Redondi R.
europepmc   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Mergers and Acquisitions in Germany - Social Setting and Regulatory Framework [PDF]

The paper describes the legal and economic environment of mergers and acquisitions in Germany and explores barriers to obtaining and executing corporate control.
Frank A. Schmid, Mark Wahrenburg
core  

Ownership changes in the pharmaceutical industry: understanding the 2023 pharma mergers and acquisitions landscape of Europe. [PDF]

J Pharm Policy Pract
Fabian D, Wild C.
europepmc   +1 more source