Results 21 to 30 of about 5,284 (242)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Operation Standard for Sling Exercise with Tuina Therapy of Traditional Chinese Medicine Rehabilitation Techniques

康复学报, 2023
The technique of sling exercise with Tuina therapy is a rehabilitation technique that combines traditional Chinese medicine and Western medicine.
LI Li, CHANG Guangzhe, SUN Guodong, SUN Jinglong, FENG Ziyun, MA Zhaoshui, CHENG Yiran   +6 more
doaj  

Electrical impedance of acupuncture meridians: the relevance of subcutaneous collagenous bands. [PDF]

PLoS ONE, 2010
The scientific basis for acupuncture meridians is unknown. Past studies have suggested that acupuncture meridians are physiologically characterized by low electrical impedance and anatomically associated with connective tissue planes.
Andrew C Ahn, Min Park, Jessica R Shaw, Claire A McManus, Ted J Kaptchuk, Helene M Langevin   +5 more
doaj   +1 more source

Meridians 5:1 [PDF]

, 2004
The time has come to offer my parting words as the editor of Meridians as I close the final issue of the journal under my supervision on a warm spring day in the Pioneer Valley of Massachusetts....https://scholarworks.smith.edu/meridians/1032/thumbnail ...
Chancy, Myriam J.A.
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Meridians 8:2 [PDF]

, 2008
Meridians\u27 flag is planted squarely on that piece of discursive ground where both race and gender reside. As feminist scholars/activists know, that space, with its fluid borders, can be one of liberation or possess the doubly weighted discord of ...
Giddings, Paula J.
core   +1 more source

Estudo comparativo entre dois protocolos de tratamento Flor de Liz e Método Canal Unitário em algias cervicais

Revista Dor
JUSTIFICATIVA E OBJETIVOS: A acupuntura é um método terapêutico utilizado há aproximadamente 5.000 anos que promove a harmonização e o fortalecimento do corpo. A cervicalgia atinge 28% da população. A Organização Mundial da Saúde de 2004 afirma que dores
Ana Maria Vieira Gardin, Flávia Alves de Almeida Felipe   +1 more
doaj   +1 more source

Components of Lens Power That Regulate Surface Principal Powers and Relative Meridians Independently

International Journal of Optics, 2016
Paraxial light rays incident in air on alternate refracting surfaces of a thick lens can yield complementary powers. This paper aims to test when these powers are invariant as surface refractive powers interchange in the expression. We solve for relevant
H. Abelman, S. Abelman
doaj   +1 more source

Effect of flapping-meridians combined with thunder-fire moxibustion on upper limb dysfunction after stroke

Journal of Integrative Nursing, 2020
Objective: The objective of the study is to explore the effect of flapping-meridians combined with thunder-fire moxibustion in the treatment of upper limb dysfunction after stroke.
Feng-Guang GUAN, Qiu-Lu JI, Yue-Qing JIANG, Zhuo-Mei ZHUANG, Xiao-Qin LIAN   +4 more
doaj   +1 more source