Results 21 to 30 of about 15,113 (309)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
康复学报, 2023 The technique of sling exercise with Tuina therapy is a rehabilitation technique that combines traditional Chinese medicine and Western medicine.
LI Li +6 more
doaj
Electrical impedance of acupuncture meridians: the relevance of subcutaneous collagenous bands. [PDF]
PLoS ONE, 2010 The scientific basis for acupuncture meridians is unknown. Past studies have suggested that acupuncture meridians are physiologically characterized by low electrical impedance and anatomically associated with connective tissue planes.
Andrew C Ahn +5 more
doaj +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Components of Lens Power That Regulate Surface Principal Powers and Relative Meridians Independently
International Journal of Optics, 2016 Paraxial light rays incident in air on alternate refracting surfaces of a thick lens can yield complementary powers. This paper aims to test when these powers are invariant as surface refractive powers interchange in the expression. We solve for relevant
H. Abelman, S. Abelman
doaj +1 more source
Journal of Integrative Nursing, 2020 Objective: The objective of the study is to explore the effect of flapping-meridians combined with thunder-fire moxibustion in the treatment of upper limb dysfunction after stroke.
Feng-Guang GUAN +4 more
doaj +1 more source
Measurement of Scleral Thickness in Humans Using Anterior Segment Optical Coherent Tomography. [PDF]
PLoS ONE, 2015 Anterior segment optical coherent tomography (AS-OCT, Visante; Zeiss) is used to examine meridional variation in anterior scleral thickness (AST) and its association with refractive error, ethnicity and gender.
Hetal D Buckhurst +3 more
doaj +1 more source
MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis
FEBS Open Bio, EarlyView.MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss +7 more
wiley +1 more source
Revista DorJUSTIFICATIVA E OBJETIVOS: A acupuntura é um método terapêutico utilizado há aproximadamente 5.000 anos que promove a harmonização e o fortalecimento do corpo. A cervicalgia atinge 28% da população. A Organização Mundial da Saúde de 2004 afirma que dores
Ana Maria Vieira Gardin +1 more
doaj +1 more source