Results 31 to 40 of about 5,690 (248)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Frontiers in PhysiologyBackgroundThe anatomical basis of meridian pathways remains a central challenge in modernizing Traditional Chinese Medicine (TCM). Concurrently, modern science has redefined the integrated fascial-interstitial system as a pervasive, fluid-filled cavitary
Yu Xia +5 more
doaj +1 more source
康复学报, 2023 The technique of sling exercise with Tuina therapy is a rehabilitation technique that combines traditional Chinese medicine and Western medicine.
LI Li +6 more
doaj
, 2009 One of the most important missions of feminist scholarship is to recognize missing voices, perspectives, and representations. A major theme in this issue of Meridians is the restoration and re-visioning of those hidden, excluded, or marginalized aspects ...
Giddings, Paula J.
core
Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source
Biological fundamental functional units of meridians: mechanosensitive ion channels
Frontiers in MedicineMeridians are central to the theory of Traditional Chinese Medicine (TCM), yet their biological essence remains elusive. Mechanosensitive ion channels (MS channels) respond to diverse physical stimuli, and their properties closely parallel the ...
Yiming Wang, Xiaojing Zhou, Songbin He
doaj +1 more source
, 2008 Meridians\u27 flag is planted squarely on that piece of discursive ground where both race and gender reside. As feminist scholars/activists know, that space, with its fluid borders, can be one of liberation or possess the doubly weighted discord of ...
Giddings, Paula J.
core
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
Effects of yoga practice on acumeridian energies: Variance reduction implies benefits for regulation
International Journal of Yoga, 2013 Background and Objective: This paper concerns mechanisms responsible for the efficacy of yoga medicine, traditionally attributed to the enlivenment of prana.
Niharika Nagilla +2 more
doaj +1 more source