Results 21 to 30 of about 12,177 (250)
Revista DorJUSTIFICATIVA E OBJETIVOS: A acupuntura é um método terapêutico utilizado há aproximadamente 5.000 anos que promove a harmonização e o fortalecimento do corpo. A cervicalgia atinge 28% da população. A Organização Mundial da Saúde de 2004 afirma que dores
Ana Maria Vieira Gardin +1 more
doaj +1 more source
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source
康复学报, 2023 The technique of sling exercise with Tuina therapy is a rehabilitation technique that combines traditional Chinese medicine and Western medicine.
LI Li +6 more
doaj
Components of Lens Power That Regulate Surface Principal Powers and Relative Meridians Independently
International Journal of Optics, 2016 Paraxial light rays incident in air on alternate refracting surfaces of a thick lens can yield complementary powers. This paper aims to test when these powers are invariant as surface refractive powers interchange in the expression. We solve for relevant
H. Abelman, S. Abelman
doaj +1 more source
Effects of yoga practice on acumeridian energies: Variance reduction implies benefits for regulation
International Journal of Yoga, 2013 Background and Objective: This paper concerns mechanisms responsible for the efficacy of yoga medicine, traditionally attributed to the enlivenment of prana.
Niharika Nagilla +2 more
doaj +1 more source
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source