Results 21 to 30 of about 2,458 (69)

Carbapenem‐Resistant Klebsiella pneumoniae Isolated From a Patient in a Midwestern U.S. Hospital With a History of Indian Travel: Therapeutic Strategies and Clinical Outcomes

Case Reports in Infectious Diseases, Volume 2025, Issue 1, 2025.
Carbapenemases have had increasing prevalence within the United States and worldwide. Here, we present a case of carbapenem‐resistant Klebsiella pneumoniae (CRKP) which is unique due to the rarity of multiple mechanisms of resistance within the Klebsiella pneumoniae harboring New Delhi metallo‐β‐lactamases (NDM), oxacillinase‐48 (OXA‐48)‐like, and ...
Christopher Phan, Kristen Tsai, Christian M. Gill, Robin Chamberland, Christian Hendrix, Rong Hou, Dawei Cui   +6 more
wiley   +1 more source

Spotlight commentary: Treatment of multidrug‐resistant Gram‐negative infections in the era of growing antimicrobial resistance

British Journal of Clinical Pharmacology, Volume 91, Issue 9, Page 2485-2489, September 2025.
Luka Bielen, Andro Vujević, Luka Csenar
wiley   +1 more source

Cockroaches as Reservoirs, Vectors, and Potential Sentinels of Multidrug‐Resistant Bacteria in Ugandan Communities: A Retrospective Analysis

Global Health, Epidemiology and Genomics, Volume 2025, Issue 1, 2025.
Background: Cockroaches could play a role in the transmission dynamics of antimicrobial‐resistant bacteria (ARB) at variable interfaces in Ugandan communities, acting as both reservoirs and vectors. This study investigated the burden and diversity of ARB carried by cockroaches in human settlements in Uganda, so as to understand their role in the spread
Steven Kakooza, Paul Ssajjakambwe, Rebecca Nalubega, Betty Namazi, Aisha Nantume, Geoffrey Ssentamu, Esther Nabatta, David Nalumenya, Mariam Wanyana, Damien F. N. Munyiirwa, Dorcus Namuyinda, Sayaka Tsuchida, Kazunari Ushida, John Baligwamunsi Kaneene, Omar Enzo Santangelo   +14 more
wiley   +1 more source

Revisiting the Metallo‐β‐Lactamase–Mediated Antibiotic Resistance: Exploring Novel Mechanisms and Therapeutic Strategies

International Journal of Microbiology, Volume 2025, Issue 1, 2025.
β‐Lactam resistance is one of the major health concerns today, primarily due to enzymes called β‐lactamases. Metallo‐β‐lactamases (MβLs) can cleave a wide range of β‐lactam antibiotics, including carbapenems. These enzymes require zinc (Zn) ions to function and can be inhibited by conventional β‐lactamase inhibitors.
Jahanvi Saini, Silvi Gautam, Divakar Sharma, Ankit Khanduri, Divya Venugopal, Guilherme Dilarri   +5 more
wiley   +1 more source

A Focused Review on Commercially Available Automated Systems for Antibiotic Susceptibility Testing

Journal of Tropical Medicine, Volume 2025, Issue 1, 2025.
The battle against antibiotic resistance demands innovative solutions for efficient and accurate antibiotic susceptibility testing (AST). Traditional methods, though reliable, are often time‐consuming and labor‐intensive, limiting their ability to provide timely results in clinical settings.
Qumars Ghavami, Haider Abd Ulhai Nasser, Seyedeh Shadi Vaziri, Majid Taati Moghadam, Rajib Chowdhury   +4 more
wiley   +1 more source

Expanding the β‐Lactamase Family in the Human Microbiome

Advanced Science, Volume 11, Issue 46, December 11, 2024.
β‐lactam resistance is mainly driven by β‐lactamases. The study analyzes 1369 characterized and 16 204 putative β‐lactamases, identifying nine from eight clusters. The highest gut β‐lactamase abundance is found in Japan and the lowest in Fiji. β‐lactamase levels correlate with β‐lactam use and income, increasing in colorectal cancer and cardiovascular ...
Baolei Jia, Ju Hye Baek, Jae Kyeong Lee, Ying Sun, Kyung Hyun Kim, Ji Young Jung, Che Ok Jeon   +6 more
wiley   +1 more source

Recovery of clinically relevant multidrug‐resistant Klebsiella pneumoniae lineages from wastewater in Kumasi Metropolis, Ghana

Environmental Microbiology Reports, Volume 16, Issue 6, December 2024.
This study revealed a significant prevalence of antimicrobial resistance in Klebsiella pneumoniae and Pseudomonas aeruginosa isolates from wastewater, exhibiting diverse resistance profiles, including co‐resistance to antibiotics and heavy metals. These findings underscore the critical need for continuous One Health surveillance to mitigate the spread ...
Amen Ekhosuehi, Odion O. Ikhimiukor, Helen Michelle Korkor Essandoh, Nana Yaw Asiedu, Isoken Tito Aighewi, Gabriel Temitope Sunmonu, Erkison Ewomazino Odih, Anderson O. Oaikhena, Dorothy Cyril‐Okoh, Clara Yeboah, Iruka N. Okeke   +10 more
wiley   +1 more source

Epidemiology and clinical significance of carbapenemases in Australia: a narrative review

Internal Medicine Journal, Volume 54, Issue 4, Page 535-544, April 2024.
Abstract Carbapenemase‐producing gram‐negative bacteria (CP‐GNB) infections threaten public health with high mortality, morbidity and treatment costs. Although frequencies remain low in Australia (total number of CP‐GNB infections reported was 907 in 2022), blaIMP‐4 has established low levels of endemicity in many states.
Abdullah Tarik Aslan, David L. Paterson
wiley   +1 more source

EHA2024 Hybrid Congress

HemaSphere, Volume 8, Issue S1, June 2024.
wiley   +1 more source

Meropenem/vaborbactam activity against carbapenem-resistant Klebsiella pneumoniae from catheter-related bloodstream infections. [PDF]

Front Cell Infect Microbiol
Sivori F, Francalancia M, Truglio M, Cavallo I, Pronesti C, Fabrizio G, Celesti I, Cazzani A, Furzi L, Pimpinelli F, Di Domenico EG.   +10 more
europepmc   +1 more source