Results 221 to 230 of about 352,942 (315)

Nucleotide‐bound crystal structures of the SARS‐CoV‐2 helicase NSP13

open access: yesActa Crystallographica Section F, Volume 81, Issue 8, Page 338-347, August 2025.
Nucleotide‐bound crystal structures of SARS‐CoV‐2 NSP13 capture a state immediately following ATP hydrolysis and reveal how crystal packing can affect structure‐based drug design targeting NSP13.Nucleotide‐bound crystal structures of SARS‐CoV‐2 NSP13 in ADP‐ and ATP‐bound states were resolved to 1.8 and 1.9 Å, respectively. The ADP‐bound model captures
Patrick Kloskowski   +3 more
wiley   +1 more source

A Short‐Read Amplicon Sequencing Protocol and Bioinformatic Pipeline for Ecological Surveillance of Dipteran Disease Vectors

open access: yesMolecular Ecology Resources, Volume 25, Issue 6, August 2025.
ABSTRACT Vector control remains an important strategy worldwide to prevent human infection with pathogens transmitted by arthropods. Vector control strategies rely on accurate identification of vector taxa along with vector‐specific biological indicators such as feeding ecology, infection prevalence and insecticide resistance.
Raquel Lima‐Cordón   +18 more
wiley   +1 more source

Designed miniproteins potently inhibit and protect against MERS-CoV. [PDF]

open access: yesCell Rep
Ragotte RJ   +22 more
europepmc   +1 more source

Effective target genes for RNA interference‐based management of the cabbage stem flea beetle

open access: yesInsect Molecular Biology, Volume 34, Issue 4, Page 527-539, August 2025.
An oral RNAi screen consisting of 27 dsRNAs identified effective target genes for RNAi‐based pest control in the cabbage stem flea beetle The most effective target genes were involved in proteasomal pathways or gene expression, and their sequences were subjected to in silico off‐target analysis Knock‐down of some effective target genes also inhibited ...
Doga Cedden   +5 more
wiley   +1 more source

Development of a Rapid Isothermal Assay for Detection of Adenovirus Types Important in Respiratory Infections

open access: yesInfluenza and Other Respiratory Viruses, Volume 19, Issue 8, August 2025.
ABSTRACT Background Nucleic acid amplification tests (NAATs) for human adenoviruses (HAdVs) causing respiratory infections usually target the hexon gene. However, new HAdV types with substantial variations in the hexon gene may not be detected. Thus, we focus on NAATs based on a conserved region in the penton gene to detect all HAdV types causing ...
Benedikt Beilstein   +4 more
wiley   +1 more source

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