Results 61 to 70 of about 4,805 (216)

A randomized phase II trial of gemcitabine, nab‐paclitaxel, cisplatin with or without a medically supervised ketogenic diet for patients with metastatic pancreatic cancer

open access: yesCancer, Volume 132, Issue 6, 15 March 2026.
ABSTRACT Background A randomized phase II screening trial of gemcitabine, nab‐paclitaxel, and cisplatin with a medically supervised ketogenic diet (MSKD) versus usual diet (non‐MSKD) was conducted in patients with treatment‐naive metastatic pancreatic ductal adenocarcinoma (PDAC).
Gayle S. Jameson   +21 more
wiley   +1 more source

A phase 1 study of berzosertib (M6620, VX‐970) in combination with cisplatin and radiation in patients with locally advanced head and neck squamous cell carcinoma (ETCTN 9950)

open access: yesCancer, Volume 132, Issue 6, 15 March 2026.
ABSTRACT Background Ataxia telangiectasia Rad3‐related (ATR) protein kinase regulates DNA damage response and is essential for tumor cell survival. Preclinically, ATR inhibition can sensitize tumor cells to radiation and chemotherapy. The authors conducted a phase 1 trial of berzosertib, a selective ATR inhibitor, in combination with definitive ...
Aarti Bhatia   +26 more
wiley   +1 more source

Delivering precision oncology in metastatic breast cancer: Clinical impact of comprehensive genomic profiling—The CATCH experience

open access: yesInternational Journal of Cancer, Volume 158, Issue 6, Page 1675-1689, 15 March 2026.
What's new? CATCH is a prospective precision oncology registry trial that harnesses whole‐genome/exome‐ and RNA‐sequencing to enable actionable biomarker detection in metastatic breast cancer patients of any subtype. The data of the first 412 consecutive patients with completed follow‐up in this real‐world, single‐center patient cohort provide robust ...
Mario Hlevnjak   +31 more
wiley   +1 more source

Determinants of Migration to Accrual Accounting For the Central and Devolved Governments in Kenya

open access: yesDisclosure
Kenya’s public sector accounting is grappling with ongoing challenges that undermine fiscal transparency and accountability at both the national and county levels. Specifically, there are issues with accounting practices, such as unverified expenditures,
Solomon Ngahu, Cecilia Ndunge Waweru
doaj   +1 more source

Woody plant along the elevation gradient of Mt. Meru, Tanzania

open access: green, 2023
Julius Vincent Lasway   +5 more
openalex   +1 more source

Multiomic characterization of small cell lung cancer: Real‐world insights into therapeutic opportunities

open access: yesCancer, Volume 132, Issue 5, 1 March 2026.
NK, natural killer; STING, Stimulator of Interferon Genes; TCI, T‐cell inflamed. Abstract Background The dominant expression of lineage‐related transcription factors (TFs)—ASCL1, NEUROD1, POU2F3, and, controversially, YAP1—has enabled the classification of small cell lung cancer (SCLC) into distinct subtypes (SCLC‐A/N/P/Y, respectively).
Sonam Puri   +18 more
wiley   +1 more source

Reducing the Burden of Interaction Studies in Cancer Patients Using a Stable Isotopically Labeled Microtracer: A Proof‐of‐Concept Study with Alectinib

open access: yesClinical Pharmacology &Therapeutics, Volume 119, Issue 3, Page 713-720, March 2026.
Traditional drug‐food interaction studies of oral anticancer agents have a high patient burden. A patient‐friendly alternative approach to studying food effects could be the use of stable isotopically labeled microtracers. A prospective, single‐center, open‐label, crossover, food effect study with the microtracer 2H6‐alectinib was conducted in patients
Ma Ida Mohmaed Ali   +9 more
wiley   +1 more source

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