Results 11 to 20 of about 77 (67)

Impact of cerebral small vessel disease on cognitive outcomes in early age at onset MCI and dementia: Findings from the DIASPORA study. [PDF]

Alzheimers Dement
Abstract BACKGROUND This study assessed the impact of cerebral small vessel disease (CSVD) on cognition in individuals with early‐onset (EO; <65 years) and late‐onset (LO; ≥65 years) cognitive complaints. METHODS Participants underwent prospective evaluations including cognitive testing, hyperphosphorylated tau‐217 (p‐tau217) and neurofilament‐light ...
Naftali J, Glik A, Eliahou R, Rabninovici GD, Rosen HJ, Elahi F, Benninger F, Goldberg I, Auriel E, Keret O.   +9 more
europepmc   +2 more sources

Alzheimer's disease patients have smaller venous drainage system compared to cognitively healthy controls. [PDF]

Alzheimers Dement
Abstract INTRODUCTION One of the pathological hallmarks of Alzheimer's disease (AD) is the accumulation of amyloid beta 42 (Aβ42). Decreased venous drainage may enhance Aβ42 accumulation. We aimed to compare venous cross‐sectional area (CSA) of AD patients to cognitively healthy controls.
Pardo K, Khasminsky V, Keret O, Benninger F, Goldberg I, Shelef I, Auriel E, Glik A.   +7 more
europepmc   +2 more sources

Study of brain perfusion in adults with Down syndrome along the Alzheimer's disease continuum. [PDF]

Alzheimers Dement
Abstract INTRODUCTION We assessed pseudo‐continuous arterial spin labeling (pCASL) sensitivity to detect changes in cerebral blood flow (CBF) in adults with Down syndrome (DS) along the Alzheimer's disease (AD) continuum and explored the similarity with sporadic AD (sAD) hypoperfusion profile.
Franquesa-Mullerat M, Morcillo-Nieto AO, Arriola-Infante JE, Zsadanyi SE, Vaqué-Alcázar L, Rozalem-Aranha M, Arranz J, Rodríguez-Baz Í, Maure-Blesa L, Videla L, Barroeta I, Del Hoyo Soriano L, Benejam B, Fernández S, Sanjuan Hernandez A, Giménez S, Alcolea D, Belbin O, Lleó A, Carmona-Iragui M, Fortea J, Bejanin A.   +21 more
europepmc   +2 more sources

Generational effects in Down syndrome: Enriched environment enhances functionality without reducing Alzheimer's disease risk. [PDF]

Alzheimers Dement
Abstract INTRODUCTION Down syndrome (DS) is the leading cause of intellectual disability (ID) and a genetic form of Alzheimer's disease (AD). We wanted to assess whether generational changes have induced (1) milder ID with greater independence and (2) delayed AD diagnosis.
Vaqué-Alcázar L, Videla L, Benejam B, Del Hoyo Soriano L, Barroeta I, Fernandez S, Rodríguez-Baz Í, Arriola-Infante JE, Arranz J, Maure Blesa L, Sanjuan-Hernández A, Morcillo-Nieto AO, Bejanin A, Arenaza-Urquijo EM, Lleó A, Bartrés-Faz D, Carmona-Iragui M, Fortea J.   +17 more
europepmc   +2 more sources

Characterization of white matter hyperintensities in Down syndrome. [PDF]

Alzheimers Dement
Abstract INTRODUCTION In Down syndrome (DS), white matter hyperintensities (WMHs) are highly prevalent, yet their topography and association with sociodemographic data and Alzheimer's disease (AD) biomarkers remain largely unexplored. METHODS In 261 DS adults and 131 euploid controls, fluid‐attenuated inversion recovery magnetic resonance imaging scans
Morcillo-Nieto AO, Zsadanyi SE, Arriola-Infante JE, Carmona-Iragui M, Montal V, Pegueroles J, Aranha MR, Vaqué-Alcázar L, Padilla C, Benejam B, Videla L, Barroeta I, Fernandez S, Altuna M, Giménez S, González-Ortiz S, Bargalló N, Ribas L, Arranz J, Torres S, Iulita MF, Belbin O, Camacho V, Alcolea D, Lleó A, Fortea J, Bejanin A.   +26 more
europepmc   +2 more sources

Alpha-synuclein co-pathology in Down syndrome-associated Alzheimer's disease. [PDF]

Alzheimers Dement
Abstract INTRODUCTION Alpha‐synuclein (αSyn) seed amplification assay (SAA) enables in vivo study of αSyn but remains underexplored in Down syndrome‐associated Alzheimer's disease (DSAD). METHODS We analyzed αSyn‐SAA in cerebrospinal fluid (CSF) from 270 adults with Down syndrome, from the Down Alzheimer Barcelona Neuroimaging Initiative and from the ...
Bernhardt AM, Rodríguez-Baz Í, Aldecoa I, Arranz J, Arriola-Infante JE, Maure-Blesa L, Carmona-Iragui M, Longen S, Trossbach SV, Giese A, Matthias T, Benejam B, Videla L, Del Hoyo Soriano L, Barroeta I, Sanjuan A, Fernández S, Vaqué-Alcázar L, Rozalem Aranha M, Morcillo-Nieto AO, Nübling G, Wagemann O, Stockbauer A, Tondo M, Bejanin A, Lleó A, Alcolea D, Molina-Porcel L, Fortea J, Levin J.   +29 more
europepmc   +2 more sources

Cortical microinfarcts in adults with Down syndrome assessed with 3T-MRI. [PDF]

Alzheimers Dement
Abstract BACKGROUND Cortical microinfarcts (CMI) were attributed to cerebrovascular disease and cerebral amyloid angiopathy (CAA). CAA is frequent in Down syndrome (DS) while hypertension is rare, yet no studies have assessed CMI in DS. METHODS We included 195 adults with DS, 63 with symptomatic sporadic Alzheimer's disease (AD), and 106 controls with ...
Aranha MR, Montal V, van den Brink H, Pegueroles J, Carmona-Iragui M, Videla L, Maure Blesa L, Benejam B, Arranz J, Valldeneu S, Barroeta I, Fernández S, Ribas L, Alcolea D, González-Ortiz S, Bargalló N, Biessels GJ, Blesa R, Lleó A, Coutinho AM, Leite CC, Bejanin A, Fortea J.   +22 more
europepmc   +2 more sources

Special Issue: Abstracts of the 11^th Congress of the European Academy of Neurology, Helsinki, Finland. [PDF]

Eur J Neurol
European Journal of Neurology, Volume 32, Issue S1, June 2025.
europepmc   +2 more sources

Basal forebrain atrophy along the Alzheimer's disease continuum in adults with Down syndrome

Alzheimer's &Dementia, Volume 19, Issue 11, Page 4817-4827, November 2023., 2023
Abstract Background Basal forebrain (BF) degeneration occurs in Down syndrome (DS)‐associated Alzheimer's disease (AD). However, the dynamics of BF atrophy with age and disease progression, its impact on cognition, and its relationship with AD biomarkers have not been studied in DS. Methods We included 234 adults with DS (150 asymptomatic, 38 prodromal
Mateus Rozalem Aranha, Maria Florencia Iulita, Victor Montal, Jordi Pegueroles, Alexandre Bejanin, Lídia Vaqué‐Alcázar, Michel J. Grothe, Maria Carmona‐Iragui, Laura Videla, Bessy Benejam, Javier Arranz, Concepción Padilla, Sílvia Valldeneu, Isabel Barroeta, Miren Altuna, Susana Fernández, Laia Ribas, Natalia Valle‐Tamayo, Daniel Alcolea, Sofía González‐Ortiz, Núria Bargalló, Henrik Zetterberg, Kaj Blennow, Rafael Blesa, Thomas Wisniewski, Jorge Busciglio, A. Claudio Cuello, Alberto Lleó, Juan Fortea   +28 more
wiley   +1 more source

classecol: Classifiers to understand public opinions of nature

Methods in Ecology and Evolution, Volume 12, Issue 7, Page 1329-1334, July 2021., 2021
Abstract Human perceptions of nature, once the domain of the social sciences, are now an important part of environmental research. However, the data and tools to tackle this research are lacking or are difficult to apply. Here, we present a collection of text classifier models to identify text relevant to the broad topics of hunting and nature ...
Thomas F. Johnson, Hebe Kent, Bethan M. Hill, Georgia Dunn, Leonie Dommett, Natasha Penwill, Tom Francis, Manuela González‐Suárez   +7 more
wiley   +1 more source