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2020
This chapter focuses on mesenchymal stem cells (MSCs), a multipotent stem cell type that has been found in a variety of tissues and organs of the human body since their discovery in 1970. Their main function is to maintain and repair the respective tissue in vivo.
Margit Schulze +3 more
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This chapter focuses on mesenchymal stem cells (MSCs), a multipotent stem cell type that has been found in a variety of tissues and organs of the human body since their discovery in 1970. Their main function is to maintain and repair the respective tissue in vivo.
Margit Schulze +3 more
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Mesenchymal Stem Cell Engineering
2018Mesenchymal stem cells (MSC) are multipotent stem cells that display the capacity to generate the tissue in which they reside. MSC have been used as progenitor cells to engineer cartilage implants that can be used to repair chondral and osteochondral lesions, or as trophic producers of bioactive factors to initiate endogenous regenerative activities in
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Proteome of mesenchymal stem cells
PROTEOMICS, 2007AbstractProteomics has evolved, in recent years, into effective tools for basic and applied stem cell research, and has been extensively used to facilitate the identification of changes in signal transduction components, especially with regard to plasticity, proliferation, and differentiation.
Jun Seop Shin +2 more
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Mesenchymal Autologous Stem Cells
World Neurosurgery, 2015The use of cell-based therapies for spinal cord injuries has recently gained prominence as a potential therapy or component of a combination strategy. Experimental and clinical studies have been performed using mesenchymal stem cell therapy to treat spinal cord injuries with encouraging results.
Jaderson Costa da Costa +1 more
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2017
Mesenchymal stem cells (MSCs) derived from adult human bone marrow hold a spectrum of functional properties. Intravenous infusion of MSCs provides functional improvements in animal models including cerebral stroke and spinal cord injury. Suggested mechanisms may include neuroprotection, angiogenesis, induction of axonal sprouting, and remyelination.
Osamu Honmou, Masanori Sasaki
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Mesenchymal stem cells (MSCs) derived from adult human bone marrow hold a spectrum of functional properties. Intravenous infusion of MSCs provides functional improvements in animal models including cerebral stroke and spinal cord injury. Suggested mechanisms may include neuroprotection, angiogenesis, induction of axonal sprouting, and remyelination.
Osamu Honmou, Masanori Sasaki
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Circulating mesenchymal stem cells
The International Journal of Biochemistry & Cell Biology, 2004Mesenchymal precursor cells (MPCs) are multipotent cells capable of differentiating into various mesenchymal tissues, such as bone, cartilage, fat, tendon and muscle. They are present within both mesenchymal tissues and the bone marrow (BM). If marrow-derived MPCs are to have a role in repair and fibrosis of mesenchymal tissues, transit of these cells ...
Natalie C. Direkze +4 more
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Cryobanking Mesenchymal Stem Cells
2017Cryopreservation and storage of culture-expanded mesenchymal stem cells (MSCs) is essential for a biobank to maintain a collection of cell lines for research and clinical use. Optimization of cryopreservation protocols and methods to minimize damage to cells during freezing and thawing is critical to ensure reliable availability of viable cells ...
Andres Pavon +3 more
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Aging of mesenchymal stem cells
Ageing Research Reviews, 2006The role of adult mesenchymal stem cells (MSC) in tissue maintenance and regeneration has received significant attention of late. Questions arise to what extent these cells are either subject to, or causes of aging; whether age-related changes in these cells are due to intrinsic factors or induced by the somatic environment.
Sebastian Sethe +2 more
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Experimental Gerontology, 2005
Stem cells are located throughout the adult body of higher organisms, supporting a continuous renewal and repair of tissues. Unique abilities of stem cells are self-renewal and multipotential differentiation. It is, therefore, of critical importance for an organism to maintain and control quantity and quality of stem cells within a given pool ...
Christine Fehrer, Günter Lepperdinger
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Stem cells are located throughout the adult body of higher organisms, supporting a continuous renewal and repair of tissues. Unique abilities of stem cells are self-renewal and multipotential differentiation. It is, therefore, of critical importance for an organism to maintain and control quantity and quality of stem cells within a given pool ...
Christine Fehrer, Günter Lepperdinger
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Biology of mesenchymal stem cells
Injury, 2005Mesenchymal stem cells are present in many human tissues and serve as a readily available source of undifferentiated cells being capable to form specific tissues like bone, cartilage, fat, muscle and tendon. They represent an attractive and promising field in tissue regeneration and engineering for treatment applications in a wide range of trauma and ...
Ippokratis Pountos, Peter V. Giannoudis
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