Results 141 to 150 of about 329,977 (264)

circZNF148 Drives Glucose Metabolism Reprogramming to Enhance Metastasis and Immune Evasion via HK1 Stabilization in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
CircZNF148 stabilizes HK1 through deubiquitinase recruitment, thereby enhancing glycolysis and lactate production. Elevated lactate promotes PD‑L1 lactylation and membrane accumulation while suppressing CD8+ T‐cell cytotoxicity, collectively facilitating immune evasion and malignant progression in TNBC.
Yuhan Jin, Wenjing Zhao, Lei Wang, Jianing Wang, Keying Zhao, Dan Luo, Yifei Wang, Yuxia Yang, Jingze Yang, Yaming Li, Tong Chen, Dianwen Han, Zekun Wang, Xiaoyan Li, Bing Chen, Lijuan Wang, Yiran Liang, Qifeng Yang   +17 more
wiley   +1 more source

Intracranial mesenchymal tumor, FET::CREB fusion-positive: An integrative analysis of 81 cases. [PDF]

Neuro Oncol
Rajan S, Chung HJ, Wu Z, Singh O, Dazelle K, Abdullaev Z, Tyagi M, Ferrone CK, Raffeld M, Lee I, Gagan J, Chen J, Cathcart S, Giannini C, Nguyen A, Gokden M, Perry A, Fernandes IL, Putnam AR, Kurek K, Green RM, Eberhart C, Lucas CH, Gonzalez-Gomez I, Lopez GY, Jones K, Prayson R, Yeaney G, Dermawan JKT, Chkheidze R, Appin C, Uhlmann EJ, Taliansky A, Blessing M, Mohila C, Cotter J, Deisch J, Andreiuolo F, Crawford JR, Mount C, Stemmer-Rachamimov AO, Lakis NS, Schmidt R, Chacko G, Newbury R, Neill S, Morales B, Fecher R, Sloan EA, Solomon DA, Nasrallah M, Quezado M, Fonseca A, Aldape K.   +53 more
europepmc   +1 more source

Metabolic Reprogramming in Glioblastoma Stem Cells Promotes Radiation Resistance Through a H3K18la/USP30/MBOAT2 Axis

Advanced Science, EarlyView.
LDHA‐driven lactate production in mesenchymal glioma stem cells promotes p300‐dependent H3K18 lactylation, activates USP30 transcription, and stabilizes MBOAT2 to remodel phosphatidylethanolamines toward ferroptosis‐resistant PE‐MUFA species. Disrupting this metabolic–epigenetic–lipid circuit enhances ferroptosis and sensitizes glioblastoma to ...
Zong Miao, Wei Gu, Yimin Ren, Chenfei Lu, Wanzhi Cai, Junnan Lu, Zhongyuan Bao, Yanan Zhou, Rong Li, Ke Jin, Chao Chen, Hongxiang Wang, Lei Xu, Juxiang Chen   +13 more
wiley   +1 more source

A rare primary mediastinal mesenchymal tumor diagnosed by endobronchial ultrasound (EBUS). [PDF]

BMC Pulm Med
Argun Baris S, Kaya H, Selvi Guldiken G, Oksuzler Kizilbay G, Vural C, Basyigit I, Boyaci H.   +6 more
europepmc   +1 more source

Biochemically Constrained Multi‐Omics Integration Reveals Protein–Metabolite Dependencies Across Diseases

Advanced Science, EarlyView.
ProMetNet introduces a biologically constrained deep learning framework for proteo‐metabolomic integration by embedding Reactome‐derived pathway topology into neural networks. It captures non‐linear molecular dependencies and pathway‐level metabolic reorganization, enabling interpretable discrimination.
Minghui Zhao, Na Zhou, Ruotong Liu, Xiaofei Li, Jian Li, Fuzhong Xue, Qingzhen Hou   +6 more
wiley   +1 more source

Phosphaturic mesenchymal tumor in the temporalis muscle causing tumor-induced osteomalacia: a case report and literature review. [PDF]

Front Med (Lausanne)
Gao B, Wang C, Xu X, Lai X, Xu X.
europepmc   +1 more source

BraMARS: An Interpretable Histopathology‐Driven Deep Learning Model for Brain Metastasis Risk Stratification in Surgically Resected Limited‐Stage SCLC

Advanced Science, EarlyView.
This study presents BraMARS, an explainable deep learning model that estimates future brain metastasis risk in surgically resected limited‐stage small‐cell lung cancer using routine H&E‐stained whole‐slide images. By linking model‐attributed spatial histopathology with clinical outcomes and proteomic programs, BraMARS provides a biologically ...
Zijian Yang, Taolue Wang, Shilong Liu, Zicheng Zhang, Yibo Zhang, Fan Yang, Bo Yu, Shuaishuai Gao, Yu Chen, Lin Yang, Meng Zhou   +10 more
wiley   +1 more source

¹⁸ F-OC PET/CT Localization of a Phosphaturic Mesenchymal Tumor Presenting with Tumor-Induced Osteomalacia. [PDF]

World J Nucl Med
Hou H, Zhang L, Zhou X.
europepmc   +1 more source

Machine Learning‐Driven Design of Multicomponent Bone Inorganic Matrix Mimicking Scaffolds for Osteogenesis Enhanced by Neurogenesis

Advanced Science, EarlyView.
Schematic illustration of development of experimental datasets and algorithm models, screening and preparation of the scaffolds and their applications in vivo. ABSTRACT Bone defects require materials with osteogenic, neurogenic, and angiogenic activity, yet designing such materials within high‐dimensional compositional spaces remains challenging. Here,
Kunlu Lin, Ying Yang, Chuyao Zhou, Hanyue Mao, Zhiquan Zhang, Libangxi Liu, Xiaoying Yu, Haoming Liu, Long Liu, Xiaoyan Wang   +9 more
wiley   +1 more source

Pleural-Based GLI1-Altered Mesenchymal Tumor With ACTB-GLI1 Fusion: A Rare Pulmonary Entity Mimicking Synovial Sarcoma. [PDF]

Thorac Cancer
Lizwan M, Xiao L, Chow CY, Lau HY, Ong BH.   +4 more
europepmc   +1 more source