Results 111 to 120 of about 62,316 (261)
Experimental Physiology, EarlyView.Abstract Vascular endothelial growth factor receptor (VEGFR) inhibitors are effective antiangiogenic agents used in cancer therapy. However, they are associated with cardiovascular disease, including hypertension and vascular dysfunction. The molecular mechanisms underlying these cardiovascular toxicities are unclear, but oxidative stress might be ...
Karla B. Neves +3 more
wiley +1 more source
Maternal obesity during lactation as a hypertensive cardiovascular risk factor in the offspring
Experimental Physiology, EarlyView.Abstract Maternal obesity is a major public health concern, with growing evidence supporting its role in the developmental programming of cardiometabolic disease. Although prenatal mechanisms have been investigated extensively, the contribution of lactation as a postnatal window of cardiovascular (CV) programming remains insufficiently understood ...
Gabriela Arenas +2 more
wiley +1 more source
TMEM16A channel signalling microdomains in the regulation of vascular function
The Journal of Physiology, EarlyView.Abstract figure legend Schematic representation of TMEM16A channel signalling microdomains. Calcium influx or calcium release from the endoplasmic/sarcoplasmic reticulum (ER/SR) activates TMEM16A channels through interactions with regulatory proteins in vascular smooth muscle cells or endothelial cells. TMEM16A channel activation drives chloride efflux,
Fênix Araujo, Swapnil K. Sonkusare
wiley +1 more source
Amyloid β alters vascular CaV1.2 channel spatiotemporal properties
The Journal of Physiology, EarlyView.Abstract figure legend Amyloid‐β1‐42 (Aβ1‐42) triggers a male‐specific signalling cascade influencing CaV1.2 spatiotemporal properties in cerebral vascular smooth muscle. The signalling pathway involves NADPH oxidase (NOX)‐derived reactive oxygen species (ROS) activation of protein kinase C (PKC). Aβ1‐42 can also activate protein kinase A (PKA).
Jade L. Taylor +5 more
wiley +1 more source
Unveiling the role of the venous system in arterial hypertension: A computational study
The Journal of Physiology, EarlyView.Abstract figure legend This abstract figure summarizes the principal findings of our computational analysis of hypertension. Model‐based results identify reduced venous compliance as a major determinant of elevated arterial pressure, second only to increased peripheral resistance.
Eleuterio F. Toro +4 more
wiley +1 more source
Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights
The Journal of Physiology, EarlyView.Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò +18 more
wiley +1 more source
DEN Open, Volume 7, Issue 1, April 2027.ABSTRACT Duodenal self‐expandable metal stents (SEMS) are widely used to treat malignant gastric outlet obstruction (GOO). However, stent migration is a well‐known complication. We report a rare case of small‐bowel impaction caused by the migration of a duodenal SEMS with a biliary plastic stent (PS).
Shinsuke Otagiri +9 more
wiley +1 more source
Mistaken Identity: Superior Mesenteric Vein Syndrome Presenting as Superior Mesenteric Artery Syndrome. [PDF]
ACG Case Rep JPatel P +5 more
europepmc +1 more source
DEN Open, Volume 7, Issue 1, April 2027.ABSTRACT Background and Aims This study aimed to assess the prognosis and outcomes of additional treatment for residual adenocarcinoma and adenoma following endoscopic papillectomy (EP) for ampullary tumors. Methods Of 191 patients who underwent EP, 43 with adenocarcinoma or adenoma and either positive or unknown pathological margins were included ...
Yusuke Kurita +24 more
wiley +1 more source