Results 71 to 80 of about 585,346 (301)

Early Enzyme Replacement Therapy Does Not Prevent the Protein Losing Enteropathy Syndrome in Neurovisceral Gaucher Disease

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Gaucher disease (GD) is a rare lysosomal storage disorder characterized by multisystemic involvement. With the advent of enzyme replacement therapy (ERT), patient survival has improved, revealing new long‐term complications. We report a case of a 4‐year‐old male with severe neurovisceral GD who developed protein‐losing enteropathy (PLE ...
Vincenza Gragnaniello, Mara Cananzi, Annachiara Cavaliere, Christian Loro, Chiara Cazzorla, Daniela Gueraldi, Andrea Puma, Alberto B. Burlina   +7 more
wiley   +1 more source

Microbiota Restrict Trafficking of Bacteria to Mesenteric Lymph Nodes by CX3CR1hi Cells

Nature, 2013
The intestinal microbiota has a critical role in immune system and metabolic homeostasis, but it must be tolerated by the host to avoid inflammatory responses that can damage the epithelial barrier separating the host from the luminal contents. Breakdown
G. Diehl, R. Longman, Jing-xin Zhang, Béatrice Bréart, C. Galan, Adolfo Cuesta, S. Schwab, D. Littman   +7 more
semanticscholar   +1 more source

The intestinal lymphatic system: Functions and metabolic implications [PDF]

, 2019
The lymphatic system of the gut plays important roles in the transport of dietary lipids, as well as in immunosurveillance and removal of interstitial fluid.
Cifarelli, Vincenza, Eichmann, Anne
core   +2 more sources

Ethnomedicinal Uses, Phytochemistry, Pharmacological Activities, and Toxicology of the Subfamily Gomphrenoideae (Amaranthaceae): A Comprehensive Review

Chemistry &Biodiversity, EarlyView.
ABSTRACT The subfamily Gomphrenoideae is composed of about 480 accepted species, many of which have been historically used as medicinal plants, reason why they have been studied in terms of chemical profile, biological activity, and safety. This review consolidates the advances in research on this subfamily over the past 47 years, emphasizing its ...
Dayanna Isabel Araque Gelves, Giulia Cristina de Andreoli Souza, Alvaro Jose Hernandez Tasco, Marcos José Salvador   +3 more
wiley   +1 more source

A study on the conversion of carotene into vitamin A by fluorescence microphotometry [PDF]

, 1971
For the purpose to confirm whether carotene is converted into vitamin A mainly in the intestine, fluorescence microscope observations as well as the fluorescence microphotometry for the estimation of fading state of the fluorescence were carried out on ...
Iimori, Saburo
core   +1 more source

RORγt‐APCs: The New Masters of Oral Tolerance

Barrier Immunity, EarlyView.
ABSTRACT Oral tolerance is defined by the hypo‐responsiveness of our body to fed antigens, and its failure can lead to immune‐mediated diseases, such as allergy, chronic inflammation and autoimmune diseases. Decades of research have demonstrated that antigen‐presenting cells (APCs) promote oral tolerance by inducing regulatory T cells (Tregs) and/or ...
Thierry Gauthier, WanJun Chen
wiley   +1 more source

Therapeutic DNA vaccine induces broad T cell responses in the gut and sustained protection from viral rebound and AIDS in SIV-infected rhesus macaques. [PDF]

, 2012
Immunotherapies that induce durable immune control of chronic HIV infection may eliminate the need for life-long dependence on drugs. We investigated a DNA vaccine formulated with a novel genetic adjuvant that stimulates immune responses in the blood and
A Gallimore, A Kirmaier, A Watson, AA Lackner, AL Seman, AM Amedee, Amithi Narendran, Angela M. Amedee, AS von Gegerfelt, Brendon Wahlberg, Chen Liang, Cristy Stagnar, D Chen, D Verhoeven, DC Montefiori, Deborah Heydenburg Fuller, DH Barouch, DH Fuller, DH Fuller, DH Fuller, DH Fuller, E Rollman, E Tryniszewska, Eric J. Yager, EY Enioutina, EY Enioutina, Fiona C. Cook, GM Glenn, H Takeuchi, Heather Michael, HL Robinson, IM Belyakov, IM Belyakov, IM Belyakov, IM Belyakov, J Arrington, J Lisziewicz, J zur Megede, JD Boyer, Jenny W. Che, JJ Donnelly, JJ Kim, JM Brenchley, Joel R. Haynes, John Tite, JQ Wu, JR Haynes, Julia Nyaundi, JW Mellors, LA Knapp, LJ Berry, LN Martin, M Genesca, M Murphey-Corb, Michael Murphey-Corb, MR Betts, PA Mudd, Peter Ertl, Premeela Rajakumar, PT Loudon, R De Rose, R Taber, R Tubiana, RA Daynes, Rachel Taber, RR Amara, RS Veazey, RT Gandhi, S Staszewski, SA Riddler, SJ Kent, SJ Wilson, SY Lim, T Nakajima, TM Pertmer, TU Vogel, TW Chun, TW Chun, U Sauermann, W Lu, W Lu, WP Kong, X Wang, Y Levy, Z Hel   +84 more
core   +4 more sources

The crosstalk between immune activation and metabolism in heart failure. A scientific statement of the Heart Failure Association of the ESC

European Journal of Heart Failure, EarlyView.
Abstract A better understanding of additional mechanisms of heart failure (HF) progression may allow a different and more complete phenotyping of the disease and identification of novel therapeutic targets. Persistent latent myocardial inflammation/immune activation in HF may represent an attempt to restore tissue homeostasis in the failing heart ...
Gabriele Fragasso, Davide Stolfo, Markus S. Anker, Antoni Bayes‐Genis, Ovidiu Chioncel, Stephane Heymans, Pardeep S. Jhund, Basil S. Lewis, Gary D. Lopaschuk, Lars H. Lund, Arantxa Gonzalez, Matteo Pagnesi, Gabriele Giacomo Schiattarella, Carlo Gabriele Tocchetti, Peter van der Meer, Sophie Van Linthout, Sven Wassmann, B. Daan Westenbrink, Marco Metra, Giuseppe M.C. Rosano, Gianluigi Savarese   +20 more
wiley   +1 more source

To respond or not to respond - a personal perspective of intestinal tolerance [PDF]

, 2018
For many years, the intestine was one of the poor relations of the immunology world, being a realm inhabited mostly by specialists and those interested in unusual phenomena.
A Besredka, A Goubier, A Iwasaki, A Konrad, A Limmer, A Mortha, A Vaillant, AJ MacPherson, Allan McI. Mowat, AM Mowat, B Cassani, B Dubois, B Jabri, B Johansson-Lindbom, C Asseman, C Berlin, C Siewert, C Varol, CC Bain, CC Bain, CL Scott, CL Scott, CM Sun, CR Mackay, CR Stokes, D Esterhazy, D Fina, D Mucida, D Sichien, DP McGovern, DS Shouval, E Jaensson, E Jaensson-Gyllenback, E Mazzini, E Zigmond, EJ Kunkel, EM Nilsen, EM Nilsen, F Broere, F Ginhoux, F Hauet-Broere, F Powrie, FG Chirdo, G Lack, G Matteoli, G Mayrhofer, G Monteleone, GG MacPherson, H Arentz-Hanson, H Fukaura, H Tlaskalova, HG Wells, HL Klaasen, HL Weiner, HL Weiner, I Vicente-Suarez, ID Iliev, II Ivanov, J Farache, J Farache, JA Mattingly, JA Mattingly, JB Sun, JF Heremans, JH Niess, JL Coombes, JL Gowans, JL Viney, JM Blander, JP Hugot, JR Battisto, JR McDole, K Atarashi, K Atarashi, K Lahl, K Nagatani, K Takeda, KG McDonald, KM Luda, KM Smith, KP Zimmer, KS Kim, L Maiuri, L Maiuri, L Saurer, LA Hanson, LA Reynolds, LA Waaij van der, LM Sollid, M Boucard-Jourdin, M Butler, M Chieppa, M Karlsson, M Murai, M Rescigno, M Rimoldi, M Tsuji, M Yoshida, MH Jang, MH Jang, MO Li, MR Hepworth, MR Karlsson, MW Chase, N Korneychuk, N Satoh-Takayama, N Sudo, O Schulz, P Brandtzaeg, P Morrissey, PA Crabbe, PB Carter, PM Smith, R Bouziat, R Kuhn, R Zeng, R Zeng, RE Araya, RL Owen, RW DePaolo, S Hue, S Husby, S Husby, S Kawamoto, S Strobel, S Strobel, S Veenbergen, S Wilks, SI Hammerschmidt, SK Mazmanian, SV Kim, T Joeris, T Worbs, TB Tomasi Jr, TL Denning, U Hadis, V Cerovic, V Gaboriau-Routhiau, Y Chen, Y Cong, Y Ogura, ZM Falchuk, Ø Molberg   +142 more
core   +1 more source

Elucidating the Potential of Dietary Hemp Seed on Gut Health: Recent Advances and Future Perspectives

Food Chemistry International, EarlyView.
Hemp seed has been shown to improve gut health by enhancing intestinal barrier function, increasing the expression of tight junction proteins, reducing pro‐inflammatory cytokines, modulating gut microbiota composition, and influencing the production of short‐chain fatty acids, which contribute to overall gut homeostasis.
Dekun Cheng, Jieun Woo, Senay Simsek, Weicang Wang   +3 more
wiley   +1 more source