Results 101 to 110 of about 468,384 (335)

RORγt‐APCs: The New Masters of Oral Tolerance

Barrier Immunity, EarlyView.
ABSTRACT Oral tolerance is defined by the hypo‐responsiveness of our body to fed antigens, and its failure can lead to immune‐mediated diseases, such as allergy, chronic inflammation and autoimmune diseases. Decades of research have demonstrated that antigen‐presenting cells (APCs) promote oral tolerance by inducing regulatory T cells (Tregs) and/or ...
Thierry Gauthier, WanJun Chen
wiley   +1 more source

Metastatic Status and Dissection Effect of Regional/Extraregional Lymph Nodes in Japanese Patients with Squamous Cell Carcinoma of the Anal Canal: A Multicenter Retrospective Cohort Study

Journal of the Anus, Rectum and Colon
Objectives: Squamous cell carcinoma of the anal canal (SCCA) is a rare condition. Standard treatment includes chemoradiotherapy, with surgical treatment reserved for limited cases. In the future, the decrease in surgical frequency makes it more difficult
Takayuki Torigoe, Keiji Hirata, Kazutaka Yamada, Yoichi Ajioka, Kenichi Sugihara   +4 more
doaj   +1 more source

The crosstalk between immune activation and metabolism in heart failure. A scientific statement of the Heart Failure Association of the ESC

European Journal of Heart Failure, EarlyView.
Abstract A better understanding of additional mechanisms of heart failure (HF) progression may allow a different and more complete phenotyping of the disease and identification of novel therapeutic targets. Persistent latent myocardial inflammation/immune activation in HF may represent an attempt to restore tissue homeostasis in the failing heart ...
Gabriele Fragasso, Davide Stolfo, Markus S. Anker, Antoni Bayes‐Genis, Ovidiu Chioncel, Stephane Heymans, Pardeep S. Jhund, Basil S. Lewis, Gary D. Lopaschuk, Lars H. Lund, Arantxa Gonzalez, Matteo Pagnesi, Gabriele Giacomo Schiattarella, Carlo Gabriele Tocchetti, Peter van der Meer, Sophie Van Linthout, Sven Wassmann, B. Daan Westenbrink, Marco Metra, Giuseppe M.C. Rosano, Gianluigi Savarese   +20 more
wiley   +1 more source

Accumulation of eosinophils in intestine-draining mesenteric lymph nodes occurs after Trichuris muris infection

Parasite immunology (Print), 2011
Eosinophils have recently been demonstrated capable of localizing to lymph nodes that drain mucosal surfaces, in particular during T helper 2 (Th2) responses.
M. Svensson, L. Bell, M. Little, M. Deschoolmeester, R. Locksley, K. Else   +5 more
semanticscholar   +1 more source

Distribution of primed T cells and antigen-loaded antigen presenting cells following intranasal immunization in mice.

PLoS ONE, 2011
Priming of T cells is a key event in vaccination, since it bears a decisive influence on the type and magnitude of the immune response. T-cell priming after mucosal immunization via the nasal route was studied by investigating the distribution of antigen-
Annalisa Ciabattini, Elena Pettini, Fabio Fiorino, Gennaro Prota, Gianni Pozzi, Donata Medaglini   +5 more
doaj   +1 more source

Elucidating the Potential of Dietary Hemp Seed on Gut Health: Recent Advances and Future Perspectives

Food Chemistry International, EarlyView.
Hemp seed has been shown to improve gut health by enhancing intestinal barrier function, increasing the expression of tight junction proteins, reducing pro‐inflammatory cytokines, modulating gut microbiota composition, and influencing the production of short‐chain fatty acids, which contribute to overall gut homeostasis.
Dekun Cheng, Jieun Woo, Senay Simsek, Weicang Wang   +3 more
wiley   +1 more source

Imaging interactions between the immune and cardiovascular systems in vivo by multiphoton microscopy [PDF]

, 2010
Several recent studies in immunology have used multiphoton laser-scanning microscopy to visualise the induction of an immune response in real time in vivo.
AK Robertson, BH Zinselmeyer, E Galkina, G Shakhar, GK Hansson, H Schneider, JH Huang, MJ Miller, MJ Miller, OR Millington, OR Millington, P Garside, P Maffia, S Celli, S Celli, S Hugues, T Okada, TR Mempel   +17 more
core   +1 more source

Lymphocyte transformation in the mesenteric lymph nodes of patients with Crohn's disease [PDF]

Gut, 1973
The response of lymphocytes from peripheral blood and mesenteric lymph nodes to stimulation with phytohaemagglutinin in vitro has been studied in eight patients suffering from active Crohn's disease. Patients with Crohn's disease exhibited reduced responses when compared with similar studies performed in control subjects.
Pierre J. Guillou, T. G. Brennan, G. R. Giles   +2 more
openaire   +4 more sources

Tumor desialylation surpasses anti‐PD‐L1 checkpoint therapy in restoring anti‐tumor immunity in a murine model for colorectal cancer

International Journal of Cancer, EarlyView.
What's New? Our research highlights how tumor sialylation affects tumor growth and reshapes the immune tumor microenvironment in colorectal cancer. We demonstrate for the first time that complete removal of sialic acids from colorectal tumor cells elicits a robust anti‐tumor immune response, but does not enhance anti‐PD‐L1 blockade efficacy.
Irene van der Haar Àvila, Tao Zhang, Victor Lorrain, Eelco Keuning, Laraib Amir Ali, Cora Chadick, Sara García‐García, Louis Boon, Noortje de Haan, Juan J. García‐Vallejo, Yvette van Kooyk, Sandra J. van Vliet   +11 more
wiley   +1 more source

Prognostic Role of Lymph Node Positivity and Number of Lymph Nodes Needed for Accurately Staging Small-Bowel Neuroendocrine Tumors

JAMA Surgery, 2019
Importance Little information is available regarding the minimum number of lymph nodes needed to accurately stage patients when performing a mesenteric lymphadenectomy for small-bowel neuroendocrine tumors.
Mohammad Y Zaidi, A. Lopez-Aguiar, Mary E. Dillhoff, E. Beal, G. Poultsides, Eleftherios Makris, F. Rocha, Angelena Crown, K. Idrees, Paula Marincola Smith, H. Nathan, Megan V. Beems, D. Abbott, James R Barrett, R. Fields, Jesse T Davidson, K. Cardona, S. Maithel   +17 more
semanticscholar   +1 more source