Results 111 to 120 of about 468,384 (335)

Difficulty of predicting lymph node metastasis on CT in patients with rectal neuroendocrine tumors.

PLoS ONE, 2019
BACKGROUND:Surgical indications for rectal neuroendocrine tumors with potential lymph node metastasis remain controversial. Although accurate preoperative diagnosis of nodal status may be helpful for treatment strategy, scant data about clinical values ...
Hajime Ushigome, Yosuke Fukunaga, Toshiya Nagasaki, Takashi Akiyoshi, Tsuyoshi Konishi, Yoshiya Fujimoto, Satoshi Nagayama, Masashi Ueno   +7 more
doaj   +1 more source

Mitotane Treatment for Malignant Leydig Cell Tumor: A Case Report

IJU Case Reports, EarlyView.
ABSTRACT Introduction Leydig cell tumors (LCTs), constituting 1%–3% of testicular tumors, are mostly benign, but malignant cases present treatment challenges. We report a malignant LCT case with a notable response to mitotane. Case Presentation A 43‐year‐old male presented with a right testicular induration and was diagnosed with a Leydig cell tumor ...
Daiki Katsura, Mototsugu Muramaki, Takashi Okamoto, Masaya Yamamoto, Mizuki Yutaka, Shohei Morita, Takuya Fujimoto, Yuji Yamada   +7 more
wiley   +1 more source

Therapeutic DNA vaccine induces broad T cell responses in the gut and sustained protection from viral rebound and AIDS in SIV-infected rhesus macaques. [PDF]

, 2012
Immunotherapies that induce durable immune control of chronic HIV infection may eliminate the need for life-long dependence on drugs. We investigated a DNA vaccine formulated with a novel genetic adjuvant that stimulates immune responses in the blood and
A Gallimore, A Kirmaier, A Watson, AA Lackner, AL Seman, AM Amedee, Amithi Narendran, Angela M. Amedee, AS von Gegerfelt, Brendon Wahlberg, Chen Liang, Cristy Stagnar, D Chen, D Verhoeven, DC Montefiori, Deborah Heydenburg Fuller, DH Barouch, DH Fuller, DH Fuller, DH Fuller, DH Fuller, E Rollman, E Tryniszewska, Eric J. Yager, EY Enioutina, EY Enioutina, Fiona C. Cook, GM Glenn, H Takeuchi, Heather Michael, HL Robinson, IM Belyakov, IM Belyakov, IM Belyakov, IM Belyakov, J Arrington, J Lisziewicz, J zur Megede, JD Boyer, Jenny W. Che, JJ Donnelly, JJ Kim, JM Brenchley, Joel R. Haynes, John Tite, JQ Wu, JR Haynes, Julia Nyaundi, JW Mellors, LA Knapp, LJ Berry, LN Martin, M Genesca, M Murphey-Corb, Michael Murphey-Corb, MR Betts, PA Mudd, Peter Ertl, Premeela Rajakumar, PT Loudon, R De Rose, R Taber, R Tubiana, RA Daynes, Rachel Taber, RR Amara, RS Veazey, RT Gandhi, S Staszewski, SA Riddler, SJ Kent, SJ Wilson, SY Lim, T Nakajima, TM Pertmer, TU Vogel, TW Chun, TW Chun, U Sauermann, W Lu, W Lu, WP Kong, X Wang, Y Levy, Z Hel   +84 more
core   +4 more sources

Spatial distribution and function of T follicular regulatory cells in human lymph nodes

Journal of Experimental Medicine, 2018
T follicular regulatory (Tfr) cells are a population of CD4+ T cells that express regulatory T cell markers and have been shown to suppress humoral immunity.
Ismail Sayin, Andrea J. Radtke, L. Vella, W-J Jin, E. Wherry, M. Buggert, M. Betts, R. Herati, R. Germain, D. Canaday   +9 more
semanticscholar   +1 more source

Gut microbiota and tuberculosis

iMeta, EarlyView.
This review explores the intricate relationship between gut microbiota (GM) and tuberculosis (TB). The figure illustrates the bidirectional effects between GM dynamics and TB progression, as well as the interactions between the GM and antituberculosis drugs.
Yanhua Liu, Ling Yang, Maryam Meskini, Anjana Goel, Monique Opperman, Sagar Singh Shyamal, Ajay Manaithiya, Meng Xiao, Ruizi Ni, Yajing An, Mingming Zhang, Yuan Tian, Shuang Zhou, Zhaoyang Ye, Li Zhuang, Linsheng Li, Istuti Saraswat, Ankita Kar, Syed Luqman Ali, Shakir Ullah, Syed Yasir Ali, Shradha Kaushik, Tianmu Tian, Mingyang Jiao, Shujun Wang, Giulia Ghisleni, Alice Armanni, Sara Fumagalli, WenYu Wang, Chao Cao, Maria Carpena, Miguel A. Prieto, Antonia Bruno, Chanyuan Jin, Hanqing Hu, Yuhang Zhang, Ilse du Preez, Ashok Aspatwar, Lingxia Zhang, Wenping Gong   +39 more
wiley   +1 more source

Rapid testing leads to the underestimation of the scrapie prevalence in an affected sheep and goat flock [PDF]

, 2007
To obtain a more detailed understanding of the prevalence of classical scrapie infections in a heavily affected German sheep flock (composed of 603 sheep and 6 goats), we analysed 169 sheep and 6 goats that carried the genotypes susceptible to the ...
Bellmann, Steffi, Buda, Silke, Budras, Klaus-Dieter, Buschmann, Anne, Erhardt, Georg, Fries, Reinhard, Groschup, Martin H., Hoffmann, Christine, Knobloch, Hartmut, Reckling, Karl-Friedrich, Reckzeh, Claudia   +10 more
core   +2 more sources

Reduced early life mucosal integrity decreases thymic cell counts and increases local, but not thymic regulatory, T cell recruitment: Gut mucosal integrity breach and thymic T cells

European Journal of Inflammation, 2019
Early life immune gut microbiota contact is critical for regulatory T cell–mediated oral tolerance induction. We induced a mucosal integrity breach with low dextran sulfate sodium dose right after weaning in BALB/c mice along with a standard high dose to
Hannah Louise Zakariassen, Katja Maria Bendtsen, Peter Tougaard, Axel Kornerup Hansen   +3 more
doaj   +1 more source

Macrophage‐derived reactive oxygen species promote Salmonella aggresome formation contributing to bacterial antibiotic persistence

iMeta, EarlyView.
In this study, we reveal that macrophage‐derived reactive oxygen species (ROS) can trigger the rapid formation of Salmonella aggresomes, which substantially contribute to the increased frequency of persisters induced by phagocytosis. Salmonella containing aggresomes exhibited a dormant phenotype characterized by reduced adenosine triphosphate (ATP ...
Xiao Chen, Kefan Fang, Bo Li, Yingxing Li, Yuehua Ke, Weixin Ke, Tian Tian, Yifan Zhao, Linqi Wang, Jing Geng, Mark C. Leake, Fan Bai   +11 more
wiley   +1 more source

MESENTERIC LYMPH NODES IN SIMULATED RECTAL CANCER UNDER CONDITIONS OF CHEMOTHERAPY

Сибирский онкологический журнал, 2016
The purpose of the study was to find out the typical morpho-functional changes in mesenteric lymph nodes of Wistar rats after modeling of rectal cancer and intraperitoneally injected cytostatic therapy with 5-fluorouracil and leucovorin.
N. B. Isakova, E. V. Starkova
doaj  

A gut microbiota‐bile acid axis inhibits the infection of an emerging coronavirus by targeting its cellular receptor aminopeptidase N

iMeta, EarlyView.
Bacteroides fragilis employs bile salt hydrolase to reprogram host bile acid metabolism, generating lithocholic acid that directly blocks porcine deltacoronavirus infection by disrupting spike protein‐aminopeptidase N binding, defining a microbiota‐bile acid antiviral axis with therapeutic potential against coronaviruses.
Ya‐Qing Zhang, Bin Wang, Yong‐Le Yang, Jin‐Xin Meng, Meng‐Di Zhang, Yi‐Ke Li, Bo Dong, Yanan Zhang, Bo‐Wen Liu, Dong Yang, Chun‐Miao Ji, Yao‐Wei Huang, Shu Jeffrey Zhu   +12 more
wiley   +1 more source