Results 181 to 190 of about 22,622 (290)

Tailored Porous Bimetallic Nanozyme Platform for Full‐Cycle Therapeutics of Intestinal Ischemia/Reperfusion

open access: yesAdvanced Science, Volume 13, Issue 34, 19 June 2026.
ABSTRACT Intestinal ischemia/reperfusion (I/R) injury presents a biphasic pathology: an acute oxidative‐inflammatory phase leading to organ failure, and a recovery phase marked by mucosal dysfunction and bacterial translocation. The developed MPB@TA‐Cu‐Ma nanocomposite functions as a dual‐phase therapeutic platform with significant efficacy. It rapidly
Chenghao Qiu   +15 more
wiley   +1 more source

Nano‐Enabled Systemic Delivery of STING Agonist by Engineered Silicasome for Potent Antitumor Immunotherapy

open access: yesAdvanced Science, Volume 13, Issue 34, 19 June 2026.
Engineered mesoporous silica nanoparticles (Silicasomes) enable systemic delivery of the STING agonist ADU‐S100, overcoming the instability and toxicity that limit cyclic dinucleotides to local administration. By enhancing tumor accumulation, activating systemic antitumor immunity, and remodeling the tumor immune microenvironment, these nanoparticles ...
Wenjing Zhou   +10 more
wiley   +1 more source

The Impact of Anticoagulation in Patients With Isolated Cancer‐Associated Splanchnic Vein Thrombosis: A Dual‐Center Cohort Study

open access: yesAmerican Journal of Hematology, Volume 101, Issue 6, Page 1379-1387, June 2026.
ABSTRACT Data to guide management of isolated bland cancer‐associated splanchnic vein thrombosis (CA‐SpVT) are limited. We aimed to assess the role of anticoagulation (AC) and bleeding and thrombosis in patients with CA‐SpVT. We conducted a dual‐center retrospective cohort study of adults with incident, isolated, bland CA‐SpVT from 2011 to 2020.
Abhilasha Borad   +9 more
wiley   +1 more source

Bone Marrow Failure Model Mimics Aplastic Anemia Patients: Single‐Cell Landscape of Immune Response Reveals Novel Mechanisms of Immune Imbalance in AA

open access: yesCancer Medicine, Volume 15, Issue 6, June 2026.
Single‐cell RNA‐seq is used in a mouse model of immune‐mediated bone marrow failure. Approach to platelets and mitochondrial data. Analysis of various immune cell landscapes, interactions and driving factors in BMF, involving platelets, CD4+ T Cells, CD8+ T Cells, macrophages, and mitochondrial energy metabolism pathways.
Shuai Tan   +5 more
wiley   +1 more source

Marginal Contrast Saturation‐Based Intraoperative Scoring System Predicts Objective Response to DEB‐TACE: Development and Validation of a CBCT‐Derived Real‐Time Score

open access: yesCancer Medicine, Volume 15, Issue 6, June 2026.
ABSTRACT Objective To develop and validate a simple intraoperative scoring system based on preoperative and cone‐beam CT (CBCT) features for real‐time prediction of objective response (OR) by mRECIST after DEB‐TACE in patients with HCC. Materials and Methods In this single‐center retrospective study, 274 patients (with a total of 386 HCC tumors) who ...
Zhongsong Gao   +9 more
wiley   +1 more source

Severe Lactic Acidosis in Decompensated Cirrhosis Despite Nondiagnostic Imaging

open access: yesClinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Lactic acidosis is a strong predictor of mortality in cirrhosis, reflecting both impaired hepatic clearance and systemic tissue hypoxia. We describe a 38‐year‐old man with decompensated alcohol‐associated cirrhosis who developed severe lactic acidosis despite stable hemodynamics and initially nondiagnostic vascular imaging.
Nakul Ganju   +5 more
wiley   +1 more source

Jejunal Diverticulosis as a Rare Cause of Severe Obscure Gastrointestinal Bleeding in an Elderly Patient: A Case Report

open access: yesClinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Jejunal diverticulosis is a rare cause of obscure gastrointestinal bleeding (OGIB) that can present with life‐threatening hemorrhage. We report a 69‐year‐old male with recurrent melena, severe anemia, and hemodynamic instability requiring multiple transfusions. Upper and lower endoscopy were nondiagnostic, and CT angiography failed to localize
Mahmoud Draidi   +5 more
wiley   +1 more source

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