Results 191 to 200 of about 52,133 (252)

Liver Organoids: From Disease Modelling to Regenerative Medicine

Cell Proliferation, EarlyView.
Liver organoids provide a versatile platform for disease modelling and drug discovery, leveraging stem cells and engineering techniques. They bridge research and clinical applications, offering significant potential for advancing precision medicine and regenerative therapies for liver diseases.
Tiepeng Wang, Xiaotian Qu, Jinhong Si, Junkang Meng, Ting Zhang, Shuliang Niu   +5 more
wiley   +1 more source

Mesenteric Diatrizoate Pooling Mimicking an Anastomotic Leak in Multi-Organ Dysfunction. [PDF]

Clin Case Rep
Katsuki R, Tsuda M, Irahara T, Kai T, Oishi D, Terashima T, Watanabe E.   +6 more
europepmc   +1 more source

Inborn errors of immunity in children with neuroinflammation

Developmental Medicine &Child Neurology, EarlyView.
Abstract Inborn errors of immunity (IEIs), an expanding group of monogenic disorders with diverse clinical manifestations, are increasingly recognized to include neuroinflammatory disease. Examples of diseases included under this umbrella are Aicardi–Goutières syndrome, deficiency of adenosine deaminase 2, familial haemophagocytic lymphohistiocytosis ...
Eppie M Yiu, Dilan Dissanayake, Jessie Cunningham, Helen Branson, Ori Scott, E Ann Yeh   +5 more
wiley   +1 more source

A novel ex vivo platform for functional evaluation of treatment responses in metastatic ovarian cancer. [PDF]

NPJ Precis Oncol
Valdivia A, Adefolaju A, Thang M, Stockwell C, Cuaboy LA, John C, Mann B, Satterlee A, Bae-Jump VL, Hingtgen S.   +9 more
europepmc   +1 more source

Dyslipidaemia, Chronic Kidney Disease and Diabetes Mellitus: A Triple Threat to Cardiovascular Health

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Diabetes mellitus (DM) and chronic kidney disease (CKD) frequently coexist and together create a ‘triple threat’ with dyslipidaemia, enhancing the risk for cardiovascular morbidity and mortality. Diabetic kidney disease (DKD) leads to altered lipid metabolism through insulin resistance, inflammation and oxidative stress resulting in an ...
Ann S. Forrest, Priyanka Majety, Stéphanie B. Mayer, Om P. Ganda   +3 more
wiley   +1 more source

Parasitic leiomyoma of the small bowel mesentery mimicking a gastrointestinal stromal tumor: a case report. [PDF]

Front Oncol
Lin S, Hu M, Xu Z, Weng W, Chen Y.
europepmc   +1 more source

A Biweekly GLP‐1R Agonist Designed With Drug‐Free Intervals for Enhanced Efficacy, Receptor Homeostasis and Gastrointestinal Tolerability

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aim To develop a next‐generation, longer‐acting, more‐clinical‐benefits agonist to achieve sustained efficacy with improved tolerability. Methods CT130 was designed from semaglutide. Binding affinity was validated via molecular dynamics and cellular assays.
Wei Ding, Qing Liu, Qiong Luo, Xiaojun Yao, Xingxing Fan   +4 more
wiley   +1 more source

Strangulated Ileus Caused by Clips Used for Closure of an Appendiceal Endoscopic Submucosal Dissection Perforation: A Case Report. [PDF]

DEN Open
Kanamori M, Minato Y, Banjoya S, Kimura T, Furuta K, Takeuchi N, Sawada R, Satou S, Sakuraoka Y, Ohata K.   +9 more
europepmc   +1 more source

Venous Thromboembolism in Hematologic Malignancies: Incidence, Risk Factors, and the Role of Direct Oral Anticoagulants

European Journal of Haematology, EarlyView.
ABSTRACT Thrombotic events, particularly venous thromboembolism (VTE), are a significant source of morbidity and mortality among patients with hematologic malignancies. These patients face unique challenges due to treatment‐related complications such as thrombocytopenia, coagulopathy, and heightened bleeding risk.
Mario Biglietto, Silvia Sorella, Erminia Baldacci, Massimo Breccia, Sabina Chiaretti, Marcello Capriata, Livia Donzelli, Gianna Maria D'Elia, Salvatore Giacomo Morano, Ilaria Del Giudice, Maurizio Martelli, Cristina Santoro, Antonio Chistolini   +12 more
wiley   +1 more source

Mesenteric macrophage-monocyte circuit controls systemic inflammation during enteric bacterial infection. [PDF]

J Exp Med
Kim J, Dominguez JR, Kim SH, White Z, Cho J, Hwang J, Choi Y, Tahmasebi S, Sano T, Yeom J, Kim KW.   +10 more
europepmc   +1 more source