Results 71 to 80 of about 802,113 (294)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Geometric parameters in the target matrix mesh optimization paradigm

Partial Differential Equations in Applied Mathematics, 2022
The Target Matrix Optimization Paradigm for improving mesh quality has always had, as its agenda, to create a direct path between application mesh quality requirements and a set of target matrices that can result in an optimal mesh that meets the ...
Patrick Knupp
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

A distortion measure to validate and generate curved high-order meshes on CAD surfaces with independence of parameterization [PDF]

, 2016
This is the accepted version of the following article: [Gargallo-Peiró, A., Roca, X., Peraire, J., and Sarrate, J. (2016) A distortion measure to validate and generate curved high-order meshes on CAD surfaces with independence of parameterization. Int. J.
Gargallo Peiró, Abel, Peraire Guitart, Jaume, Roca Navarro, Francisco Javier, Sarrate Ramos, Josep   +3 more
core   +2 more sources

Mesh quality metrics for isogeometric Bernstein–Bézier discretizations

Computer Methods in Applied Mechanics and Engineering, 2020
High-order finite element methods harbor the potential to deliver improved accuracy per degree of freedom versus low-order methods. Their success, however, hinges upon the use of a curvilinear mesh of not only sufficiently high accuracy but also sufficiently high quality.
Engvall, Luke, Evans, John A.
openaire   +4 more sources

Preserving mesh quality in shape optimization

PAMM, 2023
AbstractIn PDE‐constrained shape optimization, a lot of computational effort is used to update the geometry at every iteration step. This iterative process can result in loss of element quality and degeneracy of the underlying mesh, which is particularly relevant for applications involving large deformations of some parts of the domain.
Sofiya Onyshkevych, Martin Siebenborn, Winnifried Wollner   +2 more
openaire   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Kualitas Biopelet dari Limbah Batang Kelapa Sawit pada Berbagai Ukuran Serbuk dan Jenis Perekat [PDF]

, 2015
The research aimed to evaluate the effect of particle size and adhesives on the quality of biopelet from oil palm trunk. The adhesives used were tapioca and sago. The particle size were pass 10 mesh and retained 20 mesh; pass 20 mesh and retained 40 mesh;
Diba, F. (Farah), fian, Z. (Zul), haida, N. (Nur), Roslinda, E. (Emi), Setyawati, D. (Dina)   +4 more
core   +2 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Perceptual Quality and Visual Experience Analysis for Polygon Mesh on Different Display Devices

IEEE Access, 2018
Polygon mesh models have been widely used in various areas due to its high degree of verisimilitude and interactivity. Since the mesh models usually undergo various phases of signal processing for the purpose of storage, simplification, transmission, and
Youguang Yu, Fuzheng Yang, Hantao Liu, Wei Zhang   +3 more
doaj   +1 more source