Results 51 to 60 of about 977,536 (294)
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
Prospective randomized trial comparing sutured with sutureless mesh fixation for Lichtenstein hernia repair: long-term results [PDF]
, 2011 Following Lichtenstein hernia repair, up to 25% of patients experience prolonged postoperative and chronic pain as well as discomfort in the groin.
Angst, E +17 more
core +2 more sources
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Umbrella Mesh versus Mayo’s Repair in Primary Umbilical Hernia [PDF]
Basrah Journal of Surgery, 2002 Prosthetic repair has become a promising method for repairing hernias. The present study try to show the benefit of open umbrella mesh repair for umbilical hernia.
Mazin H. Al-Hawaz
doaj +1 more source
Long term recurrence, pain and patient satisfaction after ventral hernia mesh repair
, 2015 AIM: To compare long term outcomes of laparoscopic and open ventral hernia mesh repair with respect to recurrence, pain and satisfaction. METHODS: We conducted a single-centre follow-up study of 194 consecutive patients after laparoscopic and open ...
Langbach, Odd +3 more
core +1 more source
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
Amyand hernia repair with mesh and appendectomy [PDF]
Surgical Case Reports, 2019 Amyand hernias have been described in case reports in the literature and are a rare occurrence in the career of a surgeon. Their management is even less well described and often poses problems in the management of repair due to concerns with contamination associated with appendectomy. Here, we describe a patient with an Amyand hernia seen on CT imaging
Katelin Holmes, Joseph E. Guinn
openaire +3 more sources
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis
FEBS Open Bio, EarlyView.MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss +7 more
wiley +1 more source
TO EVALUATE THE COMPARATIVE STUDY OF “ONLAY” VERSES “SUBLAY” MESHPLASTY IN VENTRAL HERNIAS
Journal of University Medical & Dental College, 2014 : INTRODUCTION: Ventra hernia refer to fascial defect of the anterolateral abdominal wall through which intermittent or continuous protrusion of abdominal tissue or organ may occurs. Effective repair of ventral hernia must include a tension free approach
Bushra Jameel +2 more
doaj