Results 71 to 80 of about 26,245 (213)

A BSCB‐Penetrating Nanoplatform for Enhanced Luteolin Delivery in PRMT2‐Targeted Epigenetic Therapy of Spinal Cord Injury

Advanced Science, EarlyView.
In this work, MSN‐BO@LUT penetrates the blood‐spinal cord barrier for luteolin delivery in spinal cord injury. The nanodrug suppresses neuroinflammation and promotes functional recovery of the spinal cord. Mechanistically, luteolin targets protein arginine N‐methyltransferase (PRMT2) to decrease toll‐like receptor 4 (TLR4) methylation, thereby ...
Yixuan Wang, Bo Jin, Shipian Li, Qianxi Ouyang, Yu Xiao, Jiaxin Wen, Yehua Lai, Ping Wang, Yongjun Wang, Xuejun Cui, Weian Zhang, Min Yao   +11 more
wiley   +1 more source

The Opportunities and Challenges of Silica Nanomaterial for Atherosclerosis

International Journal of Nanomedicine, 2021
Xuan Sha,1,2 Yue Dai,1,2 Xiaoxi Song,1,2 Siwen Liu,1,2 Shuai Zhang,1,2 Jingjing Li1,2 1Department of Radiology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, People’s Republic of China; 2School of Medical Imaging, Xuzhou ...
Sha X, Dai Y, Song X, Liu S, Zhang S, Li J   +5 more
doaj  

Large Pore Mesoporous Silica and Organosilica Nanoparticles for Pepstatin A Delivery in Breast Cancer Cells

Molecules, 2019
(1) Background: Nanomedicine has recently emerged as a new area of research, particularly to fight cancer. In this field, we were interested in the vectorization of pepstatin A, a peptide which does not cross cell membranes, but which is a potent ...
Saher Rahmani, Jelena Budimir, Mylene Sejalon, Morgane Daurat, Dina Aggad, Eric Vivès, Laurence Raehm, Marcel Garcia, Laure Lichon, Magali Gary-Bobo, Jean-Olivier Durand, Clarence Charnay   +11 more
doaj   +1 more source

D4F‐Functionalized Ceria Nanozyme‐CasRx Platform Suppresses STING and Reprograms the Renal Immune Niche in Acute Kidney Injury

Advanced Science, EarlyView.
D4F‐functionalized ceria nanozyme–CasRx nanoparticles preferentially target renal macrophages through SR‐B1‐mediated uptake in ischemia–reperfusion injury. Ceria scavenges excessive ROS, while CasRx silences STING signaling, shifting macrophages toward a less inflammatory, pro‐resolving state and increasing the proportion of regulatory T cells.
Weibo Chen, Ming Li, Xuesheng Wang, Jiajia Sun, Ziyuan Zhang, Yongfeng Gong, Benkang Shi, Nengwang Yu, Yunuo Mao, Shengtian Zhao, Xiulin Zhang, Liqiang Guo   +11 more
wiley   +1 more source

Simple Cocasting Method to Prepare Magnetic Mesoporous FePt/C Composites and Their Protein Adsorption Property

Journal of Chemistry, 2013
A simple cocasting method has been developed to prepare magnetic mesoporous FePt/C composites with superparamagnetic FePt nanoparticles embedded in carbon walls.
Yufang Zhu, Xing He
doaj   +1 more source

A Multifunctional Mesoporous Janus Separator With Optimized Mass Transport Regulation Enabling 800‐Cycle Lithium‐Oxygen Batteries

Advanced Science, EarlyView.
To resolve the fundamental cycling decay of lithium‐oxygen batteries arising from lithium dendrite propagation, anode corrosion, and cathode passivation, we fabricate a mesoporous silica/polyurethane Janus separator integrating interfacial protection and mass transport modulation, which markedly enhances battery cycling stability and cycle life ...
Hailiang Mu, Anlong Liu, Kun Luo, Yaming Pang, Chengde Xie, Xiaoteng Liu, Zhihong Luo, Guangbin Zhu, Yucheng Wang, Qirong Liu, Yongbing Tang   +10 more
wiley   +1 more source

Mesoporous silica hollow capsules embedded with magnetic nanoparticles

MATEC Web of Conferences, 2017
Our method for synthesizing the mesoporous silica hollow capsules (MSHCs) was combined with the Layer-by-Layer method to integrate the magnetic nanoparticles (mNPs) onto the core template for the MSHC synthesis. The resultant magnetic MSHCs (mMSHCs) were
Yoshikawa S., Kato N., Obara G.
doaj   +1 more source

Self‐Propelled HPB@Lip@AB Nanomotors Ameliorate Dry Eye Disease

Advanced Science, EarlyView.
A self‐propelled HPB@Lip@AB nanomotor system is developed for dry eye disease (DED) therapy, facilitating rapid penetration across ocular surface barriers while integrating hydrogen therapy with multi‐enzyme‐like antioxidant activity. The nanoplatform restores mitochondrial function, suppresses oxidative stress, inflammation, and apoptosis, and ...
Jing Li, Xi Wan, Xinru Su, Zechuan Li, Yue Wang, Ying Wang, Ruofei Li, Huangzhao Wei, Jianbin Zhang, Shuai Wang   +9 more
wiley   +1 more source

Mitochondria‐Targeted Nanotherapeutics: A Promising Strategy in Modulating Mitochondrial Function, Transfer, and Transplantation

Advanced Science, EarlyView.
This review summarizes the pathogenic role of mitochondria in diseases and highlights mitochondrial transfer and transplantation as emerging therapeutic strategies. It systematically discusses how nanomaterials are engineered to facilitate these processes, and critically examines the current challenges and future perspectives for their clinical ...
Yuanyuan Su, Zhiyan Gong, Jiao Mu, Lili Huang, Pengfei Yang, Chenli Zhang, Lingshan Zhao, Liling Yang, Jun Deng, Xiaohui Liao   +9 more
wiley   +1 more source

The effect of mesoporous silica doped with silver nanoparticles on glass ionomer cements; physiochemical, mechanical and ion release analysis

BMC Oral Health
Background The purpose of the study was to evaluate the effect of adding mesoporous silica with silver nanoparticles to conventional glass ionomer cements (GIC) on its, physical, chemical, mechanical properties and ion release analysis.
Syed Saad Bin Qasim, Ali Bmuajdad
doaj   +1 more source