Results 291 to 300 of about 257,181 (321)
Some of the next articles are maybe not open access.
Intranuclear Trafficking of Messenger RNA
Critical Reviews in Eukaryotic Gene Expression, 1999Within the nucleus, protein-encoding genes are transcribed into messenger RNA by RNA polymerase II. Messenger RNAs migrate to the cytoplasm, but before reaching their final destination the primary transcripts must undergo a series of modifications that include 5'-capping, splicing, and 3'-cleavage/polyadenylation.
Noélia Custódio +2 more
openaire +2 more sources
A CRISPR cut for messenger RNAs
Lab Animal, 2020To achieve knockdown rather than knockout of particular genes, a new paper demonstrates a CRISPR/Cas13 method that can efficiently edit mRNA in zebrafish, medaka, killifish, and mouse embryos.
Rebecca Leech, Karuna Sampath
openaire +3 more sources
The structure of pre-messenger RNA and messenger RNA from erythroid cells
1977Pre-mRNA fractions (greater than 45 S) were characterized by electron microscopy. High salt concentrations (0.2 M ammonium acetate, pH 8) yield linear molecules of different length (0.5--17 micrometer). In 10% of the molecules a compact-nonlinear contour (cn-contour) is detectable at one end.
A M, Ladhoff +3 more
openaire +2 more sources
Radiation sensitivity of messenger RNA
Molecular and General Genetics MGG, 1979Messenger RNA function is inactivated by irradiation with ultraviolet light. A unit length mRNA (in bases) is 2-3 times more sensitive than a unit length of DNA (in base pairs) with respect to the inactivation of template function. These data stem from four experimental systems all of which do not repair DNA: the translation of E.
Ponta, H. +4 more
openaire +3 more sources
Splicing of Messenger RNA Precursors
Science, 1987A general mechanism for the splicing of nuclear messenger RNA precursors in eukaryotic cells has been widely accepted. This mechanism, which generates lariat RNAs possessing a branch site, seems related to the RNA-catalyzed reactions of self-splicing introns.
openaire +4 more sources
The Decay of Bacterial Messenger RNA
1996Publisher Summary The many demonstrations that the Escherichia coli (E. coli ) rne gene product (RNase E) is involved in messenger RNA (mRNA) decay have given real impetus to the study of this unusual protein's properties and role. The recent attention given to the polyadenylylation of bacterial mRNAs and the discovery that polyadenylylation ...
George J. Murakawa, Donald P. Nierlich
openaire +3 more sources
Messenger RNA Modifications in Plants
Trends in Plant Science, 2019Over 160 distinct RNA modifications are known and collectively termed the epitranscriptome. Some of these modifications have been discovered in mRNA, uncovering a new layer of gene regulation. Transcriptome-wide mapping of epitranscriptomic codes and the discovery of their writers, erasers, and readers that dynamically install, remove, and interpret ...
Chui E. Wong +3 more
openaire +3 more sources
Hormone inducible messenger RNA
Life Sciences, 1975Abstract Steroid hormones regulate the synthesis of specific proteins in target tissue by controlling the synthesis of the corresponding messenger RNA's. In the chick oviduct, estrogen and progesterone induce the synthesis and accumulation of the specific messenger RNA's for the hormone-induced egg-white proteins, ovalbumin and avidin, respectively ...
Savio L. C. Woo, Bert W. O'Malley
openaire +3 more sources
2018
The correct interpretation — that this RNA played the role of a messenger between the inserted phage DNA and the appearance of viral proteins in the bacterial cell — was provided by Jacob and Monod. Nevertheless, understanding regulation of important eukaryotic proteins requires that messenger RNAs (mRNAs) be isolated from higher organisms.
openaire +2 more sources
The correct interpretation — that this RNA played the role of a messenger between the inserted phage DNA and the appearance of viral proteins in the bacterial cell — was provided by Jacob and Monod. Nevertheless, understanding regulation of important eukaryotic proteins requires that messenger RNAs (mRNAs) be isolated from higher organisms.
openaire +2 more sources
2011
Twenty years after the seminal observation of Wolff et al. that injection of naked RNA and DNA vectors results in protein expression in vivo, messenger RNA (mRNA) vaccines have found entry into clinical development. Through improved vector design, formulation, and delivery, mRNA, initially perceived as unstable and difficult to manipulate, has been ...
Jochen Probst +5 more
openaire +2 more sources
Twenty years after the seminal observation of Wolff et al. that injection of naked RNA and DNA vectors results in protein expression in vivo, messenger RNA (mRNA) vaccines have found entry into clinical development. Through improved vector design, formulation, and delivery, mRNA, initially perceived as unstable and difficult to manipulate, has been ...
Jochen Probst +5 more
openaire +2 more sources