Results 291 to 300 of about 1,626,022 (379)

Improved Messenger RNA Stability and Biocompatibility Through Self‐Gelatinizable Nucleic Acids

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT Recent advances in the chemical synthesis and modification of messenger RNA (mRNA) have generated growing interest in mRNA‐based therapeutics. However, the inherent instability of mRNA in vivo and during storage remains a major challenge, requiring the development of safe and effective delivery systems.
Takumi Tanifuji   +5 more
wiley   +1 more source

A Phase 1/2 Randomized Study to Evaluate the Safety, Tolerability, and Immunogenicity of Nucleoside-Modified Messenger RNA Influenza Vaccines in Healthy Adults. [PDF]

open access: yesVaccines (Basel)
Branche A   +15 more
europepmc   +1 more source

Intact messenger RNA exists in human blood plasma and urine, and their purified macromolecular compartments [PDF]

open access: gold
Jasper Verwilt   +7 more
openalex   +1 more source

Exosome as bioactive nanovesicle for diagnostic and therapeutic applications in periodontitis

open access: yesBMEMat, EarlyView.
This review introduces the mechanism that exosomes participate in the pathogenesis of periodontitis and their potential as biomarkers for early diagnosis and summarizes the application of cell‐ or plant‐derived exosomes or engineered exosomes in periodontitis or periodontal regeneration while proposing the perspective of translational application of ...
Yu Wang   +6 more
wiley   +1 more source

Expression of galanin receptor messenger RNAs in different regions of the rat gastrointestinal tract

open access: green, 2005
Laura Anselmi   +4 more
openalex   +2 more sources

Calcium retinoate nanoparticle mediated microglial polarization to regulate inflammatory microenvironment for therapy of neuroinflammatory disease

open access: yesBMEMat, EarlyView.
A nano‐drug based on retinoic acid and calcium is developed, which can be rapily endocytosed by microglia and decomposed into small molecule/ion storms in lysosomes. This nano‐drug regulates microglial phenotype switching from M1 to M2 while indirectly guiding neuronal differentiation of endogenous neural stem cells, thereby ameliorating ...
Shuo Zhang   +13 more
wiley   +1 more source

Role of the circular RNAs/microRNA/messenger RNA axis in renal cell carcinoma: From gene regulation to metabolism and immunity. [PDF]

open access: yesiScience
Xu Z   +15 more
europepmc   +1 more source

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