Results 301 to 310 of about 1,593,615 (383)

Mitochondria‐Targeted Delivery of siRNA by Amphiphilic Nanovectors Self‐Assembled from a Cationic [4]Helicene‐Squalene Ester

ChemBioChem, EarlyView.
A small amphiphilic helicene effectively complexes siRNA, leading to nanoassemblies which transport siRNA to the mitochondria where it silences the protein expression of the mitochondria‐encoded cytochrome c oxidase subunit 1 gene. The active delivery of therapeutic nucleic acids with subcellular precision is an open challenge.
Lamiaa M. A. Ali, Dan–Dan Su, Rebecca Mucci, Kévin Martin, Mihail Barboiu, Jérôme Lacour, Nadir Bettache, Sébastien Ulrich   +7 more
wiley   +1 more source

Messenger RNA-encoded antibody approach for targeting extracellular and intracellular tau. [PDF]

Brain Commun
Wongsodirdjo P, Caruso AC, Yong AK, Lester MA, Vella LJ, Hung YH, Nisbet RM.   +6 more
europepmc   +1 more source

Effects of 5-Bromo-2′-Deoxyuridine on Production of Globin Messenger RNA in Dimethyl Sulfoxide-Stimulated Friend Leukemia Cells

, 1973
Harvey D. Preisler, David E. Housman, William Scher, Charlotte Friend   +3 more
openalex   +1 more source

Citrus Flavonoids for Cystic Fibrosis Treatment

ChemBioChem, EarlyView.
Studies conducted since the late 1990s show substantial activity of selected citrus flavonoids as cystic fibrosis transmembrane conductance regulator (CFTR) membrane protein activators. The thesis of this work is that aptly formulated citrus flavonoids hold sigificant potential for developing a multitarget treatment of cystic fibrosis combining in a ...
Mario Pagliaro, Caterina Di Sano, Claudia D'Anna, Giovanna Li Petri, Giuseppe Angellotti, Rosaria Ciriminna   +5 more
wiley   +1 more source

Systemic messenger RNA replacement therapy is effective in a novel clinically relevant model of acute intermittent porphyria developed in non-human primates. [PDF]

Gut
Córdoba KM, Jericó D, Jiang L, Collantes M, Alegre M, García-Ruiz L, Manzanilla O, Sampedro A, Herranz JM, Insausti I, Martinez de la Cuesta A, Urigo F, Alcaide P, Morán M, Martín MA, Lanciego JL, Lefebvre T, Gouya L, Quincoces G, Unzu C, Hervas-Stubbs S, Falcón-Pérez JM, Alegre E, Aldaz A, Fernández-Seara MA, Peñuelas I, Berraondo P, Martini PGV, Avila MA, Fontanellas A.   +29 more
europepmc   +1 more source

Virus-specific messenger RNAs in permissive cells infected by avian sarcoma virus.

, 1979
J.S. Lee, Harold Varmus, J. Michael Bishop   +2 more
openalex   +1 more source

A Phase 1, Randomized, Open‐Label, Parallel Group Study to Evaluate the Relative Bioavailability and Safety of Subcutaneous Bepirovirsen when Delivered from a Vial or Prefilled Syringe Fitted with a Safety Syringe Device in Healthy Adult Participants

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Bepirovirsen, an antisense oligonucleotide in development for the treatment of chronic hepatitis B virus (HBV) infection, is administered from glass vials as a subcutaneous (SC) injection by healthcare professionals (HCPs). A ready‐to‐use prefilled syringe (PFS) assembled with a safety syringe device (SSD) has been developed to make ...
Amir S. Youssef, Poonam Shah, Maxwell Hu, Helene Plein, Abhishek Roy, Ravi Sharma, Sarah Mole, Magdalena Blazejczyk, Wendy Cross, Brian Spears, Samuel Pak, Rejbinder Kaur, Robert Elston, Dickens Theodore, Marjan Hezareh, Ahmed Nader   +15 more
wiley   +1 more source

Large subunit ribulosebisphosphate carboxylase messenger RNA from Euglena chloroplasts.

, 1976
Daphna Sagher, Haim Grosfeld, Marvin Edelman   +2 more
openalex   +1 more source

Advancing Predictions of Oral Drug Absorption, CYP3A4 Induction, and Transporter‐Mediated Interactions Using a Human Primary Intestinal 3D Model (EpiIntestinal™)

Clinical Pharmacology &Therapeutics, EarlyView.
Accurate prediction of oral drug absorption in humans is essential for early drug development; however, physiologically relevant human models are lacking. This study aims to comprehensively assess the EpiIntestinal™, a human primary intestinal 3D model, for its ability to predict oral absorption (Fa), intestinal availability (Fg), CYP3A4 induction, and
Paresh P. Chothe, Andrea Whitcher‐Johnstone, Aniruddha Karve, Diane Ramsden, Niresh Hariparsad   +4 more
wiley   +1 more source

Designing a multi-epitope construct using immuno-informatic tools to prepare a messenger RNA vaccine against Rhipicephalus microplus ticks. [PDF]

Vet World
Ullah U, Ashraf K, Shehzad W, Rashid MI.
europepmc   +1 more source