Results 61 to 70 of about 412,114 (244)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Metástases pulmonares em crianças: estamos operando desnecessariamente?

Revista do Colégio Brasileiro de Cirurgiões, 2018
RESUMO Objetivo: determinar, em pacientes pediátricos portadores de neoplasias malignas, as características de nódulos pulmonares identificados à tomografia computadorizada, capazes de diferenciar nódulos benignos de metástases.
Andrey Kaliff Pontes, Fabio Mendes Botelho Filho, Marcelo Eller Miranda, Karla Emília de Sá Rodrigues, Bernardo Almeida Campos, Paulo Custódio Furtado Cruzeiro, Clecio Picarro, Edson Samesima Tatsuo, Diogo Ramalho Tavares Marinho, Thiago Luiz do Nascimento Lazaroni, Renan Farias Rolim Viana, Ricardo de Mattos Paixão   +11 more
doaj   +1 more source

Malignant melanoma with liver and spleen metastases: case report [PDF]

, 2000
CONTEXT: The diagnosis of primary melanoma is easily confirmed after histological analysis of the lesion, whereas it is rarely diagnosed when the patient even has distant metastases.
Lanzoni, Valeria Pereira, Ornellas, Laura Cotta, Toledo, Carlos Fischer de   +2 more
core   +4 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Metástases hepáticas de primário difícil de encontrar…

Galicia Clínica, 2017
Metastatic Cancer of Unknown Primary Site (CUP) accounts for approximately 3-5% of all malignant neoplasms and is therefore one of the 10 most frequent cancer diagnoses in men.
Ana Mondragão, Silvia Costa, Marta Barbedo, Vitor Paixão Dias   +3 more
doaj   +1 more source

Laparoscopic left lateral segmentectomy for metachronic metastases of small intestine adenocarcinoma: a case report [PDF]

, 2011
Hepatectomy has been the standard treatment for metachronic metastases of non-colorectal (NCR) origin, mainly when the disease-free interval is more than two years.
Araujo, Sergio Luiz Melo, Lima, Olímpia Alves Teixeira, Martins, Sandro José, Paes, Marcio Almeida, Pais-costa, Sergio Renato   +4 more
core   +4 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Metástases esplénicas no adenocarcinoma seroso do ovário.

Acta Médica Portuguesa, 2008
Splenic metastasis is rare, and is usually associated with disseminated malignancy. The primary tumours more frequently related with splenic metastasis are lung, breast, gynaecologic, specially ovary tumours, colon, rectum and melanoma.
Rita Roque, António Pina, Carmo Soares, António Martinho, Humberto Messias   +4 more
doaj   +1 more source

Gravidez após tratamento com 131Iodo em mulheres portadoras de carcinoma diferenciado da tiróide [PDF]

, 2007
Universidade Federal de São Paulo (UNIFESP) Departamento de Medicina Coordenadora do Ambulatório de Doenças Tiroidianas e GravidezUniversidade Federal de São Paulo (UNIFESP) Departamento de Obstetrícia Coordenadora do Ambulatório de Doenças Tiroidianas e
Matsumura, Luiza Kimiko
core   +2 more sources

Comment on: “Challenging the Odds: Long‐Term Survival in Pediatric Diffuse Midline Glioma With H3 K27M and BRAF V600 Co‐Mutations Treated With Upfront Radiotherapy and Targeted Therapy”

Pediatric Blood &Cancer, EarlyView.
Natália Dassi, Andrea Maria Cappellano
wiley   +1 more source