Results 311 to 320 of about 25,305,187 (391)

Tumor‐Associated Sympathetic Nerves Promote the Progression of Epstein‐Barr Virus‐Positive Diffuse Large B‐Cell Lymphoma

Advanced Science, EarlyView.
Sympathetic nerve innervation promotes the progression of Epstein‐Barr virus‐positive diffuse large B‐cell lymphoma (EBV+ DLBCL) via β2‐adrenergic receptors. The discovery of enhanced nerve infiltration and β2AR expression reveals a novel mechanism and highlights the sympathetic–β2AR axis as a promising target for therapeutic intervention in EBV+ DLBCL.
Silan Huang, Dexin Lei, Linbin Yang, Aiwei Bi, Yanlou Wang, Peng Zhang, Dongyu Zhuang, Honglian Liu, Qingqing Cai, Man Nie, Yi Xia   +10 more
wiley   +1 more source

Comparison of Large Language Model with Aphasia

Advanced Science, EarlyView.
Large language models (LLMs) answer almost all questions fluently but often inaccurately, which resembles a specific type of aphasia in humans. Using a data‐driven analysis called energy landscape analysis, this study reveals similarities in the internal information dynamics between LLMs and the brains of humans with receptive aphasia, such as Wernicke'
Takamitsu Watanabe, Katsuma Inoue, Yasuo Kuniyoshi, Kohei Nakajima, Kazuyuki Aihara   +4 more
wiley   +1 more source

The anatomy of the inferior mesenteric artery: a systematic review with meta-analysis. [PDF]

Surg Radiol Anat
Triantafyllou G, Belimezakis N, Lyros O, Arkadopoulos N, Demetriou F, Tsakotos G, Piagkou M.   +6 more
europepmc   +1 more source

The Nuclear Localization of ACLY Guards Early Embryo Development Through Recruiting P300 and HAT1 to Promote Histone Acetylation and Transcription

Advanced Science, EarlyView.
ACLY is vital for early embryo development. IGF‐1 activates AKT to phosphorylate ACLY, driving its nuclear localization and recruitment of HATs (P300/HAT1), boosting acetyl‐CoA production and histone acetylation for transcriptional activation. Conversely, ACLY deficiency (via knockdown, knockout, or AKT inhibition) reduces nuclear acetyl‐CoA, disrupts ...
Yerong Ma, Yingyi Zhang, Weijie Yang, Xiaomei Tong, Siya Liu, Yan Zhou, Mengjia Qiu, Huifang Jiang, Zhanhong Hu, Peipei Ren, Yan Rong, Mengru Lai, Jiamin Jin, Fei Huang, Liujian Ouyang, Feng Zhou, Heng‐Yu Fan, Yin‐Li Zhang, Songying Zhang   +18 more
wiley   +1 more source

Single‐Cell Analysis Clarifies Pathological Heterogeneity in Tenosynovial Giant Cell Tumor and Identifies Biomarkers for Predicting Disease Recurrence

Advanced Science, EarlyView.
MP3 tumor cells, a specific subpopulation of tumor cells in D‐TGCT, regulated the differentiation of CD34+ Fbs into MMP3+ Fbs and APOE+ Fbs through COL6A3 − (ITGAV + ITGB8) interaction. APOE+ Fbs activated IL‐1B+CCL20+ Mφs through the CXCL12/CXCR4 axis. IL‐1B+CCL20+ Mφs and MMP3+ Fbs participated in the local invasion of D‐TGCT.
Yubin Xie, Chen Chen, Fei Wu, Yiman Peng, Jing Su, Yang Zhao, Hongjie Huang, Zhong Alan Li, Yin Pei, Wencui Li, Yi He, Tianchen Xue, Chenxi Cao, Sui Peng, Xin Zhang, Weidong Song   +15 more
wiley   +1 more source

One‐Pot Synthesis of Chiral Succinate Dehydrogenase Inhibitors and Antifungal Activity Studies

Advanced Science, EarlyView.
This work describes an efficient synthetic method for chiral succinate dehydrogenase inhibitors, showcasing their potent and broad‐spectrum antifungal properties. Notably, substantial differences in biological activity between the enantiomers have been observed, underscoring the pivotal role of stereochemistry in the development of fungicides ...
Donghua Du, Yu Chen, Chengbing Yang, Zheng Jin, Huailong Teng   +4 more
wiley   +1 more source

Professionalism in nursing in Ethiopia: systematic review and meta-analysis. [PDF]

Front Med (Lausanne)
Edmealem A, Ayenew T, Ayenew S, Tegegne B, Ademe S, Esubalew D, Getie A, Liknaw T.   +7 more
europepmc   +1 more source

S‐ketamine Alleviates Neuroinflammation and Attenuates Lipopolysaccharide‐Induced Depression Via Targeting SIRT2

Advanced Science, EarlyView.
S‐ketamine binds directly to SIRT2, facilitating its interaction with NF‐κB p65. This interaction reduces the acetylation of NF‐κB p65 and inhibits its activation, thereby exerting anti‐inflammatory and antidepressant effects. Created by BioRender.
Cong Lin, Xiaoxuan Zhou, Mingqi Li, Cong Zhang, Haojiang Zhai, Haohong Li, Hongshuang Wang, Xiaohui Wang   +7 more
wiley   +1 more source