Results 121 to 130 of about 1,248,095 (298)

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

Identifying Cytokine Motif‐Containing, Immunomodulatory Bacterial Proteins in Human Gut Microbiome

Advanced Science, EarlyView.
By building and constructing HMM (Upper left, blue), the authors identify CMCPs in bacteria genomes and CRC related metagenomes and enriched CRC‐related CMCPs (Upper right, blue). They analyze sequence and structural similarity of hits (Lower left, green), test function with engineered EcN delivered to tumors in a mouse tumor model (Lower right, pink ...
Ziyu Wang, Siqi Guo, Jing Li, Qianqian Huang, Jing Ning, Binbin Xia, Xun Lv, Xiang Liu, Zeyu Gao, Jine Li, Longchao Liu, Moshi Song, Jun Wang   +12 more
wiley   +1 more source

Pancancer Fine‐Mapping of Mutational Intolerance Identifies CHEK1 as an Immunosuppressive Driver in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study identifies mutation‐intolerant genes (MIGs), which are mutationally constrained in tumors despite normal‐tissue variability. Using miDriver, the authors pinpoint MIGs essential for tumor‐intrinsic fitness and immune evasion. Focusing on CHEK1, they show it drives tumor fitness and sculpts an immunosuppressive niche via the MIF–CD74 axis ...
Tao Wang, Hongyu Zhao, Xiaojie Sun, Yuqi Ding, Zhipeng Zhu, Xiaotong Yu, Rongyi Zhu, Dan Wang, Kailong Li, Yang Liu, Li‐Bin Wang, Xiaolu Zhao, Baojun Suo, Hongsen Bi, Peipei Zhang, Tong Liu, Fengbiao Mao   +16 more
wiley   +1 more source

Suggestions for extending the FAIR Principles based on a linguistic perspective on semantic interoperability

Scientific Data
FAIR (meta)data presuppose their successful communication between machines and humans while preserving meaning and reference. The FAIR Guiding Principles lack specificity regarding semantic interoperability.
Lars Vogt, Philip Strömert, Nicolas Matentzoglu, Naouel Karam, Marcel Konrad, Manuel Prinz, Roman Baum   +6 more
doaj   +1 more source

Targeted youth support: Rapid Evidence Assessment of effective early interventions for youth at risk of future poor outcomes [PDF]

, 2008
This report describes the findings and methods of a systematic rapid evidence assessment (REA) of research relevant to interventions of interest to Targeted Youth Support. It was commissioned by the Department for Children, Schools and Families (DCSF) to
Dickson, Kelly, Newman, Mark, Oliver, Kathryn, Sinclair, Jennifer, Suarez, Bettina, Thomas, James, Vigurs, Carol   +6 more
core  

Reconfigurable, Temperature Resilient Phase‐Change Metasurfaces Fabricated via High Throughput Nanoimprinting Lithography

Advanced Science, EarlyView.
ABSTRACT The combination of metasurfaces with chalcogenide phase‐change materials is a highly promising route toward the development of multifunctional and reconfigurable nanophotonic devices. However, their transition into real‐world devices is hindered by several technological challenges. This includes, amongst others, the lack of large area photonic
Carlota de Ruiz de Galarreta, Yinghao Zhao, Jose Mendoza‐Carreño, José M. Caicedo, José Santiso, C. David Wright, M. Isabel Alonso, Jiafang Li, Agustin Mihi   +8 more
wiley   +1 more source

Access to mental healthcare for refugees, asylum seekers and migrants: an umbrella review of barriers

BMJ Open
Objective To identify the factors that prevent or hinder access to mental healthcare services for refugees, asylum seekers and migrants.Design An umbrella review was conducted on scoping reviews, systematic reviews, meta-analyses and meta-syntheses ...
Marc Sabbe, Birgitte Schoenmakers, Sinem Bilican, Mohamed Irfan, Antoon Cox, Heidi Salaets   +5 more
doaj   +1 more source

Is Hospital in the Home as safe and effective as inpatient care? [PDF]

When Activity-Based Funding (ABF) for public hospitals begins on 1 July this year, it should make it easier for hospitals to establish Hospital in the Home (HITH) services. The pricing framework underpinning the ABF system stipulates that public hospital
Anne-Marie Boxall, Gideon Caplan
core  

Optimal Grazing Exclusion Duration to Enhance Soil Carbon Sequestration in Degraded Grasslands

Advanced Science, EarlyView.
Across China, grazing exclusion reaches the national mean soil organic carbon recovery benchmark sooner in high‐MAP regions (> 500 mm), but recovery is much slower where MAP < 300 mm. Scaling this strategy to 70% of China's degraded grasslands would sequester about 1.52 Pg of soil carbon over 10 years—roughly 17% of annual global fossil‐fuel emissions.
Bin Zhang, Chongzhi Sun, Dongmei Xue, Paul Christiaan Struik, Tongrui Zhang, Jiayue Liu, Tingting Xing, Ziyang Liu, Shiming Tang, Ke Jin   +9 more
wiley   +1 more source

Availability, accessibility, and utilization of mental health services or support among university students in Africa: a mixed methods systematic review with meta-analysis and meta-synthesis

BMC Psychiatry
Background The literature is replete with studies documenting the magnitude of mental illness among university students in Africa. However, it is unclear what mental health services or support (MHSS) are available to students and the extent to which they
Hesborn Wao, Melvin A. Wao, Steve Bicko Omollo, Carolyne K. Mutua   +3 more
doaj   +1 more source