Results 161 to 170 of about 3,290,125 (315)

Gut Microbiome and Metabolic and Immune Indices in Males with or without Evidence of Metabolic Dysregulation

Background: The contributions of the gut microbiota to obesity and metabolic disease represent a potentially modifiable factor that may explain variation in risk between individuals.
Cox, AJ, West, NP, Chen, PY, Thang, MWC, Cripps, AW, Hatton-Jones, KM, Davoren, P   +6 more
core   +1 more source

High-Frequency Feeding With Late-Night Snacking Accelerates Type 2 Diabetes and Alters Diurnal Metabolic Gene Expression in Male KKAy Mice. [PDF]

Diabetes
Ma N, Xue Y, Tang Y, He H, Xu S, Yang X, Song R, Yang Q, Li K, Zhao Y, Cai H.   +10 more
europepmc   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Biological functions and emerging interplay of FGF21 and GDF15 in metabolic diseases and aging. [PDF]

Mol Biomed
Salmón-Gómez L, Keipert S, Catalán V, Rodríguez A, Becerril S, Frühbeck G, Gómez-Ambrosi J.   +6 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Myocardial Metabolism [PDF]

Circulation, 1955
openaire   +3 more sources

FluxSimulator: An R Package to Simulate Isotopomer Distributions in Metabolic Networks [PDF]

The representation of biochemical knowledge in terms of fluxes (transformation rates) in a metabolic network is often a crucial step in the development of new drugs and efficient bioreactors.
Thomas W. Binsl, Ivo H. M. van Stokkum, Johannes H. G. M. van Beek, Jaap Heringa, Katharine M. Mullen   +4 more
core  

The Lysosomal Clock: Are We Only as Old as Our Lysosomes? [PDF]

Traffic
Vegas AD, Galli T.
europepmc   +1 more source

Editorial: New insights of immune cells in cardiovascular and metabolic disorders

Frontiers in Immunology, 2023
Yingmei Feng, Xiangwei Xiao, Catherine Verfaillie   +2 more
doaj   +1 more source