Results 271 to 280 of about 5,522,237 (352)

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Intersecting Molecular Pathways in Cardiovascular Disease and Diabetes Mellitus: Emerging Roles of Inflammation and Therapeutics. [PDF]

Diabetes Metab Res Rev
Anagnostopoulou L, Ktenopoulos N, Apostolos A, Fragoulis C, Vlachakis P, Karakasis P, Sagris M, Milaras N, Drakopoulou M, Synetos A, Kyriazis I, Ioannidis I, Tsioufis C, Toutouzas K.   +13 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Rheumatoid Factor Beyond Rheumatoid Arthritis: A Potential Marker of Cardiometabolic and Hepatic Risk. [PDF]

Biologics
Egba SI, Orhonigbe IO, Achi NK, Ikechukwu GC, Chukwu CN, Omeoga CH.   +5 more
europepmc   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

The role of glucose metabolic reprogramming in myocarditis and advances in therapeutic strategies. [PDF]

Front Cardiovasc Med
Liu X, Han B.
europepmc   +1 more source

Hemoglobin metabolism.

Srpski arhiv za celokupno lekarstvo, 2000
openaire   +2 more sources