Results 21 to 30 of about 79,003 (287)
A rare case report of combined metformin-associated lactic acidosis and diabetic ketoacidosis
The Egyptian Journal of Internal Medicine, 2022 Background Triad of diabetic ketoacidosis (DKA) comprises of hyperglycemia with serum glucose > 11 mmol/L, high anion gap metabolic acidosis and ketonemia. Hyperlactemia is often noted in patients with DKA.
Yudara Kularathne +2 more
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Metabolic Acidosis and Subclinical Metabolic Acidosis in CKD [PDF]
Journal of the American Society of Nephrology, 2017 Metabolic acidosis is not uncommon in CKD and is linked with bone demineralization, muscle catabolism, and higher risks of CKD progression and mortality. Clinical practice guidelines recommend maintaining serum total CO2 at ≥22 mEq/L to help prevent these complications.
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Reversible acute blindness in suspected metformin-associated lactic acidosis: a case report
Journal of Medical Case Reports, 2023 Background Metformin is commonly used for the treatment of type 2 diabetes mellitus. Its multiple advantages include low risk of hypoglycemia, weight neutrality, low cost, and cardioprotective and anti-inflammatory effects.
Rui Huang, Wentao Sun
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Prevalence and severity of metabolic acidosis in patients on maintenance hemodialysis in India
Medical Journal of Dr. D.Y. Patil University, 2016 Aim: Metabolic acidosis is a feature of chronic kidney disease (CKD) due to the reduced capacity of the kidney to synthesize ammonia and excrete hydrogen ions.
Atul D Sajgure +7 more
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Pathophysiological aspect of metabolic acid-base disorders [PDF]
Medicinski Podmladak, 2016 Maintaing the arterial pH values (in normal range of 7,35-7,45) is one of the main principles of homeostasis. Regulatory responses, including chemical buffering (extracellular, intracellular, sceletal), the regulation of pCO2 by the respiratory system ...
Nešović-Ostojić Jelena
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Frontiers in Medicine, 2023 BackgroundPhysicians usually consider that sodium bicarbonate (SB) infusion can be used for metabolic acidosis; however, there is little evidence available to assess its effect on hospital mortality in large AKI cohorts.
Yunting Wang +6 more
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Metabolic Acidosis in CKD: A Review of Recent Findings
Kidney Medicine, 2021 Metabolic acidosis is fairly common in patients with chronic kidney disease (CKD). The prevalence of metabolic acidosis increases with worsening kidney function and is observed in ∼40% of those with stage 4 CKD.
Michal L. Melamed, Kalani L. Raphael
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Lactic acidosis triggers starvation response with paradoxical induction of TXNIP through MondoA. [PDF]
PLoS Genetics, 2010 Although lactic acidosis is a prominent feature of solid tumors, we still have limited understanding of the mechanisms by which lactic acidosis influences metabolic phenotypes of cancer cells. We compared global transcriptional responses of breast cancer
Julia Ling-Yu Chen +9 more
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Metabolic Acidosis in the Alligator.
Experimental Biology and Medicine, 1958 SummarySympathomimetic agents produce a severe lactate acidemia in the alligator. Although the lactate concentration often exceeded the initial alkali reserve, over 90% survived by withdrawing sodium from sources outside the extracellular fluid. The extracellular osmotic pressure rose sharply during the acute acidotic phase and fell when the lactate ...
Thomas Hernandez, Roland A. Coulson
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JA Clinical Reports, 2018 Background Methylmalonic acidemia (MMAemia) is a rare hereditary disease affecting organic acid metabolism. It causes recurrent metabolic acidosis and secondary mitochondrial dysfunction, resulting in a poor prognosis. Liver transplantation (LT) has been
Akiko Hirotsu +6 more
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