Results 111 to 120 of about 6,856,593 (214)

Systematic characterization of flux and network thermodynamic states for identification of metabolic engineering targets [PDF]

In order to identify targets for metabolic engineering interventions or understand the physiology of the cell, the first and foremost prerequisite is the knowledge or a hypothesis about the intracellular network state(s).
Hatzimanikatis, Vassily, Soh, Keng Cher, Miskovic, Ljubisa   +2 more
core  

Dual pKa Lipid Nanoparticles for Lung‐tropic mRNA Delivery and pH‐Programmed Endosomal Escape

Advanced Science, EarlyView.
Lipid nanoparticles’ bottleneck lies in low endosomal escape efficiency and liver‐dominant delivery after intravenous administration. To overcome these limitations, we present a stepwise pH‐programmed lipid nanoparticle system enabled by our newly synthesized ionizable lipid.
Seong Gi Lim, Minju Lee, Yiming Wang, Eunjin Choi, Ji Sun Park, Kyungmin Park, Hayoung Jeon, Donghyun Kim, Donghyun Lee, Yeeun Lee, Kee‐Pyo Kim, Eunha Kim, Heebeom Koo   +12 more
wiley   +1 more source

Mapping the AI life sciences landscape in Greece: a bibliometric comparison with global patterns. [PDF]

Sci Rep
Adamidi E, Chatzopoulos S, Dimopoulos AC, Krithara A, Nentidis A, Pechlivanis N, Psomopoulos F, Vergoulis T, Vichos K.   +8 more
europepmc   +1 more source

Beyond CEN.PK : parallel engineering of selected S. cerevisiae strains reveals that superior chassis strains require different engineering approaches for limonene production

Genetically engineered microbes are increasingly utilized to produce a broad range of high-value compounds. However, most studies start with only a very narrow group of genetically tractable type strains that have not been selected for maximum titers or ...
Verstrepen, Kevin J., Dai, Zongjie, Lavigne, Rob, Goossens, AlainWE098010010226010000-0002-1599-551XF4EC29BA-F0ED-11E1-A9DE-61C894A0A6B4, Pinheiro, Vitor B., Gérardin, Agathe, Yogiswara, Sasha, Zhu, Yanmei, Willekens, Anke   +8 more
core  

Metabolic engineering analysis of post-burn hepatic hypermetabolism

, 2002
Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, February 2002.Includes bibliographical references (p. 166-184).Metabolic engineering refers to the directed improvement of product formation or cellular properties ...
Lee, Kyongbum, 1972-
core  

Unravelling the Distinct Phenotype and Mechanosensitive Properties of Different Tendon Cell Populations

Advanced Science, EarlyView.
Tendon interfascicular and fascicular matrix cells are isolated and cultured, revealing distinct phenotypes and mechanosensitive responses. Interfascicular matrix cells exhibit marked stiffness‐dependent phenotypic plasticity, whereas fascicular matrix cells remain comparatively stable.
S. E. Grossemy, D. E. Zamboulis, N. S. Khatib, M. R. Fazal, C. C. Gains, A. Giannopoulos, T. Hopkins, C. Bevan, Y. Aggarwal, M. M. Knight, H. R. C. Screen   +10 more
wiley   +1 more source

Human Macrophage Polarization Dynamics on a 3D Fibrous Polydioxanone Mesh In Vitro. [PDF]

J Funct Biomater
Zonta ALS, Matera B, de Oliveira PT, Gonsales IR, Melo CES, Rossi F, Palioto DB, Ghezzi B.   +7 more
europepmc   +1 more source

Arrayed Magnetic Accelerator Synergistically Enhances Orthodontic Tooth Movement via Microtubule Assembly‐Mediated Periodontal Remodeling

Advanced Science, EarlyView.
Mechanical orthodontic treatment for malocclusion is limited by slow remodeling and risks due to poor biomechanical sensing. This study shows that static magnetic fields (SMFs) enhance mechanical sensation in periodontal ligament cells, promoting inflammation and osteoclast activity.
Yiling Lou, Jiwei Sun, Peng Chen, Caihong Mao, Junyuan Zhang, Haoqi Lei, Xiaoqing Han, Yaxuan Zhang, Yuheng Jiang, Yulin Jia, Bin Su, Lili Chen   +11 more
wiley   +1 more source

Quantification of plant structure-function relationships through micro-CT imaging-based finite element modeling. [PDF]

Plant J
Bhola D, Geitmann A.
europepmc   +1 more source

Analysis and Design of Metabolic Engineering and Synthetic Biology Strategies using Large Scale Dynamic Models of Metabolism

Systematic analysis for the redirection of carbon flux in metabolite-producing microorganisms requires the comprehensive understanding of their complex metabolic processes.
Hatzimanikatis, Vassily, Fengos, Georgios, Miskovic, Ljubisa   +2 more
core