Results 171 to 180 of about 335,580 (367)

Can the whole be less than the sum of its parts? Pathway analysis in genome-scale metabolic networks using elementary flux patterns [PDF]

, 2009
Christoph Kaleta, Luís F. de Figueiredo, Stefan Schuster   +2 more
openalex   +1 more source

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

FEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui, Silin Tu, Haibo Li, Zhancheng Zeng, Ruiqi Xiao, Jing Guo, Xiaoqi Liang, Chang Liu, Lijie Pan, Wenjie Chen, Mian Ge, Xiaofen Zhong, Linsen Ye, Huaxin Chen, Qi Zhang, Yan Xu   +15 more
wiley   +1 more source

Understanding flux switching in metabolic networks through an analysis of synthetic lethals

npj Systems Biology and Applications
Biological systems are robust and redundant. The redundancy can manifest as alternative metabolic pathways. Synthetic double lethals are pairs of reactions that, when deleted simultaneously, abrogate cell growth. However, removing one reaction allows the
Sowmya Manojna Narasimha, Tanisha Malpani, Omkar S. Mohite, J. Saketha Nath, Karthik Raman   +4 more
doaj   +1 more source

Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks [PDF]

, 2009
Xia Yang, Joshua L. Deignan, Hongxiu Qi, Jun Zhu, Su Qian, Judy Zhong, Gevork Torosyan, Sana Majid, Brie Falkard, Robert Kleinhanz, Jenny Karlsson, Lawrence W. Castellani, Sheena Mumick, Kai Wang, Tao Xie, Michael Coon, Chunsheng Zhang, Daria Estrada‐Smith, Charles R. Farber, Susanna S. Wang, Atila van Nas, Anatole Ghazalpour, Bin Zhang, Douglas J. MacNeil, John R. Lamb, Katrina M. Dipple, Marc L. Reitman, Margarete Mehrabian, Pek Yee Lum, Eric E. Schadt, Aldons J. Lusis, Thomas A. Drake   +31 more
openalex   +1 more source

Proteomics and Co-expression Network Analysis Reveal the Importance of Hub Proteins and Metabolic Pathways in Nicotine Synthesis and Accumulation in Tobacco (Nicotiana tabacum L.) [PDF]

, 2022
Zejun Mo, Lili Duan, Yuanyuan Pu, Zonglin Tian, Yuzhou Ke, Wen Luo, Kai Pi, Ying Huang, Qiong Nie, Renxiang Liu   +9 more
openalex   +1 more source

Adenosine A3 receptor antagonists as anti‐tumor treatment in human prostate cancer: an in vitro study

FEBS Open Bio, EarlyView.
The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli, Andrea Spinaci, Cui Chang, Rosaria Volpini, Catia Lambertucci, Matteo Landriscina, Vincenza Conteduca, Consuelo Amantini, Cristina Aguzzi, Laura Zeppa, Martina Giangrossi, Laura Soverchia, Matteo Santoni, Massimo Nabissi, Giorgio Santoni, Carlo Polidori   +15 more
wiley   +1 more source

Back to the future: Why we need enzymology to build a synthetic metabolism of the future

Beilstein Journal of Organic Chemistry, 2019
Biology is turning from an analytical into a synthetic discipline. This is especially apparent in the field of metabolic engineering, where the concept of synthetic metabolism has been recently developed.
Tobias J. Erb
doaj   +1 more source

R spider: a network-based analysis of gene lists by combining signaling and metabolic pathways from Reactome and KEGG databases [PDF]

, 2010
Alexey V. Antonov, Esther Schmidt, Sabine Dietmann, Maria Krestyaninova, Henning Hermjakob   +4 more
openalex   +1 more source

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

Profiling the effect of low frequency mechanical vibration on the metabolic and oxidative stress responses of A431 carcinoma

FEBS Open Bio, EarlyView.
20 Hz mechanical vibration induced A431 cancer cells' apoptosis without such effect on other healthy cell lines of L929 and C2C12. Lowered glucose consumption is observed specifically in A431. The expressions of ROS, HMGB1, and HSP1 levels initially increase and subsequently decrease in the cancer cell line, as opposed to L929 and C2C12, which ...
Wresti L. Anggayasti, Chikahiro Imashiro, Takashi Morikura, Shogo Miyata, Akira Funahashi, Kenjiro Takemura   +5 more
wiley   +1 more source