Results 81 to 90 of about 3,909,262 (243)

Age-Related Glucose Intolerance Is Associated with Impaired Insulin Secretion in Community-Dwelling Japanese Adults: The Kumamoto Koshi Study

Biomedicines
Background/Objectives: Glucose tolerance progressively declines with age. However, the effects of aging on insulin secretion and insulin sensitivity in Japanese subjects are unclear.
Kazuki Fukuda, Masaki Haneda, Naoto Kubota, Eiichi Araki, Kazuya Yamagata   +4 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

MiR-7 in neurological disorders: beyond metabolic dysregulation

Frontiers in Neuroscience
Brain health depends on the fine coordination of metabolic and neuronal pathways, and disturbances in this balance are recognized as major drivers of neurodegenerative, neurological, and neuropsychiatric disorders.
Cristina Puigdueta, Virginia Pardo-Marqués, Marta Torrecilla-Parra, Mario Fernández-de Frutos, José L. López-Aceituno, Carmen Zamora, Yaiza López-Manchedo, Rebeca Busto, Cristina M. Ramírez   +8 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

The causes of individual and seasonal variation in the metabolic rate of knot calidris canutus [PDF]

, 1998
Basal metabolic rate (BMR), an individual bird's minimum rate of energy expenditure, was followed in adult and juvenile captive Knot throughout their annual cycle, in conjunction with measurements of total body mass (BM) and body composition (lean mass ...
Selman, Colin
core  

Towards more biological mutation operators in gene regulation studies [PDF]

, 2003
Genetic regulation is often viewed as a complex system whose properties emerge from the interaction of regulatory genes. One major paradigm for studying the complex dynamics of gene regulation uses directed graphs to explore structure, behaviour and ...
Wiles, J., Nicholas Geard, Watson, J., Geard, N, Wiles, Janet, Watson, James, Janet Wiles, Wiles, J, Watson, J, James Watson, Geard, N.L., Geard, Nicholas   +11 more
core   +1 more source

Genome‐wide screen reveals a universal role of ATP in ciprofloxacin tolerance among genetically distinct Escherichia coli persisters

mLife
Bacterial persisters show tolerance to bactericidal antibiotics and play essential roles in chronic infections; however, the general mechanisms underlying persister formation and antibiotic tolerance remain insufficiently characterized.
Zhenfang Mei, Yawen Cai, Jianfeng Huang, Kedong Zhao, Zuqin Zhang, Dandan Yu, Shiyan Lu, Zeying Lai, Thomas K. Wood, Xinmiao Fu   +9 more
doaj   +1 more source

Fatty Acid Accumulation and Resulting PPARα Activation in Fibroblasts due to Trifunctional Protein Deficiency

PPAR Research, 2012
To examine fatty acid accumulation and its toxic effects in cells, we analyzed skin fibroblasts from six patients with mitochondrial trifunctional protein deficiency, who had abnormalities in the second through fourth reactions in fatty acid β-oxidation ...
Masato Wakabayashi, Yuji Kamijo, Takero Nakajima, Naoki Tanaka, Eiko Sugiyama, Tian Yangyang, Takefumi Kimura, Toshifumi Aoyama   +7 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Metabolic and behavioral compensations in response to caloric restriction: Implications for the maintenance of weight loss [PDF]

, 2009
BackgroundMetabolic and behavioral adaptations to caloric restriction (CR) in free-living conditions have not yet been objectively measured.Methodology and principal findingsForty-eight (36.8+/-1.0 y), overweight (BMI 27.8+/-0.7 kg/m(2)) participants ...
Eric Ravussin, Ravussin, E., Corby K. Martin, Leanne M Redman, Heilbronn, L., Corby K Martin, James P. Delany, Lilian de Jonge, Leonie K Heilbronn, Donald A Williamson, James P Delany, de Jonge, L., DeLany, J., Redman, L., Leanne M. Redman, null null, Martin, C., Pennington CALERIE Team, Williamson, D., Leonie K. Heilbronn, Donald A. Williamson   +20 more
core   +2 more sources