Results 311 to 320 of about 4,251,211 (372)

Metabolic syndrome in children and adolescents: definitions, epidemiology, pathophysiology, interventions, and challenges. [PDF]

Front Endocrinol (Lausanne)
Zhang B, Shi H, Cai W, Yang B, Xiu W.
europepmc   +1 more source

The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis

Advanced Science, EarlyView.
This review summarizes recent advances in understanding the immune microenvironment's role in fibrosis, focusing on phenotypic/functional alterations of immune cells and their dynamic interactions with other cellular constituents within tissues. The authors further explore therapeutic opportunities and challenges in targeting immune microenvironment ...
Xiangqi Chen, Chuan Wu, Fei Tang, Jingyue Zhou, Li Mo, Yanping Li, Jinhan He   +6 more
wiley   +1 more source

Cardiovascular-kidney-metabolic Syndrome: a current and urgent concept. [PDF]

J Bras Nefrol
Abreu AP, Drager LF, Almeida MQ, Bortolotto LA, Lopes HF.   +4 more
europepmc   +1 more source

Inhalable Artificial Polymeric Nucleases Degrading Neutrophil Extracellular Trap‐DNAs and Alleviating Pulmonary Fibrosis

Advanced Science, EarlyView.
Pulmonary fibrosis (PF) is promoted by NETs that induce fibroblast activation. PEG‐PIm, a polymeric artificial DNase is reported that efficiently degrades NET‐DNA via phosphodiester bond hydrolysis. Inhalation of PEG‐PIm in a mouse PF model prevents fibroblast activation and fibrosis progression, offering a promising therapeutic strategy for NET ...
Yibo Du, Chenxu Zhu, Ruifeng Wang, Shi Chen, Chuang Li, Defang OuYang, Lixin Liu, Yongming Chen   +7 more
wiley   +1 more source

Sexual dimorphism in the antitumor immune responses elicited by the combination of fasting and chemotherapy

Cancer Communications
Andrés Pastor‐Fernández, Manuel Montero Gómez de las Heras, Jose Ignacio Escrig‐Larena, Marta Barradas, Cristina Pantoja, Adrian Plaza, Jose Luis Lopez‐Aceituno, Esther Durán, Alejo Efeyan, Maria Mittelbrunn, Lola Martinez, Pablo Jose Fernandez‐Marcos   +11 more
doaj   +1 more source

Association Between Nut Consumption and Metabolic Syndrome in Korean Adults. [PDF]

J Lipid Atheroscler
Shin S.
europepmc   +1 more source

Animal models and programming of the metabolic syndrome

, 2001
Caroline Bertram, Mark A. Hanson
openalex   +1 more source

BRD4 Signaling Maintains the Differentiated State of β Cells

Advanced Science, EarlyView.
The comprehensive exploration revealed the critical role of BRD4 in β cells. BRD4 plays a fundamental role in maintaining β cell differentiation because both long‐term and acute BRD4 deficiency result in a reduction in insulin secretion and downregulation of differentiation markers.
Fuqiang Liu, Guang Liu, Jia Song, Yujing Sun, Mengmeng Yang, Hualin Liu, Hongkai Zhao, Jiamu Chen, Qincheng Qiao, Siyue Li, Chenglong Yu, Jingru Qu, Ying Zou, Tixiao Wang, Jidong Liu, Lei Zhao, Huihui Tian, Tao Huang, Manna Zhang, Li Chen, Ruxing Zhao, Yuanyuan Du, Xinguo Hou   +22 more
wiley   +1 more source

The Role of Adiponectin and <i>ADIPOQ</i> Variation in Metabolic Syndrome: A Narrative Review. [PDF]

Genes (Basel)
Błażejewska W, Dąbrowska J, Michałowska J, Bogdański P.   +3 more
europepmc   +1 more source

Rapamycin Alleviates Heart Failure Caused by Mitochondrial Dysfunction and SERCA Hypoactivity in Syntaxin 12/13 Deficient Models

Advanced Science, EarlyView.
Rapamycin alleviates heart failure via TFEB and CaMKII pathways in Syntaxin 12/13 deficient models. Stx12 deficiency causes heart failure via impaired iron trafficking to mitochondria, reducing respiratory complexes and sarcoplasmic reticulum Ca2+‐ATPase (SERCA).
Run‐Zhou Yang, Fang Li, Jiao Liu, Shu‐Ang Li, Dan‐Hua Liu, Zhuanbin Wu, Pei‐Pei Liu, Wenju Liu, Bin Zhou, Cizhong Jiang, Haibing Zhang, Ying Yu, Jian‐Sheng Kang   +12 more
wiley   +1 more source