Results 121 to 130 of about 198,582 (348)
Reprograming of proteasomal degradation by branched chain amino acid metabolism
Aging Cell, Volume 21, Issue 12, December 2022., 2022 Using genetics and multi‐omics analyses in Caenorhabditis elegans, we identified adaptive regulation of the ubiquitin‐proteasome system (UPS) in response to defective branched chain amino acid (BCAA) metabolism. Worms with impaired BCAA metabolism show slower turnover of a GFP‐based proteasome substrate, which is suppressed by loss‐of‐function of the ...
Sonia Ravanelli +5 more
wiley +1 more source
The genetic basis of classical galactosaemia in Polish patients
Orphanet Journal of Rare Diseases, 2021 Classic galactosemia (OMIM #230400) is an autosomal recessive disorder caused by homozygous or compound heterozygous pathogenic variants in the galactose-1-phosphate uridylyltransferase gene (GALT; 606999) on chromosome 9p13. Its diagnosis is established
Aleksandra Jezela-Stanek +5 more
doaj +1 more source
Kinetic Modelling and Inference of Hyperpolarized 13C Molecules in Cancer Metabolism [PDF]
arXiv, 2017 Hyperpolarized 13C-MRI allows real time observation of metabolism in vivo. Imaging sequences have been developed to follow the metabolism of [1-13C] pyruvate and extract reaction kinetics, which can show tumour treatment response. We applied the fitting model and algorithm for the imaging data of mice tumour models and determined error estimates for ...
arxiv
Substrate reduction therapy for inborn errors of metabolism
Emerging Topics in Life Sciences, 2019 Inborn errors of metabolism (IEM) represent a growing group of monogenic disorders each associated with inherited defects in a metabolic enzyme or regulatory protein, leading to biochemical abnormalities arising from a metabolic block.
W. Yue, S. Mackinnon, G. A. Bezerra
semanticscholar +1 more source
Exploration, EarlyView.Auditory brain‐computer interface connects the brain with external devices and decodes neural signals related to auditory perception. Time‐domain and frequency‐domain analyses are commonly used to identify biomarkers associated with auditory rehabilitation, such as cortical auditory evoked potentials and mismatch negativity.
Qi Zheng +6 more
wiley +1 more source
Aging Cell, Volume 21, Issue 12, December 2022., 2022 Across studies, metformin seems to prolong lifespan in nematodes fed a specific bacterial diet but not in mice and may have a larger effect if started early in life. Abstract There is growing interest in the use of metformin to extend lifespan and prevent the onset of age‐related disorders in non‐diabetic individuals.
Austin J. Parish, William R. Swindell
wiley +1 more source
Models of Innate Neural Attractors and Their Applications for Neural Information Processing [PDF]
arXiv, 2015 In this work we reveal and explore a new class of attractor neural networks, based on inborn connections provided by model molecular markers, the molecular marker based attractor neural networks (MMBANN). We have explored conditions for the existence of attractor states, critical relations between their parameters and the spectrum of single neuron ...
arxiv
Exploiting epigenetics for the treatment of inborn errors of metabolism
Journal of Inherited Metabolic Disease, 2019 Gene therapy is currently considered as the optimal treatment for inborn errors of metabolism (IEMs), as it aims to permanently compensate for the primary genetic defect.
M. Rutten, M. Rots, M. Oosterveer
semanticscholar +1 more source
Berries: Health Effects via Modulation of the Gut Microbiota
Food Frontiers, EarlyView.ABSTRACT Berries are widely regarded as beneficial foods, rich in polyphenols, flavonoids, and other bioactive compounds that could positively influence human health. Although the gut microbiota plays a crucial role in metabolism and physiology of humans, the interaction between berries and human gut microbiota activity remains unclear.
Manjin Xu +11 more
wiley +1 more source
Cysteine restriction‐specific effects of sulfur amino acid restriction on lipid metabolism
Aging Cell, Volume 21, Issue 12, December 2022., 2022 The proposed mechanism of CR‐specific effects of SAAR on adipose metabolism. (1) Due to the lack of Cys in SAAR diets, it imposes both MR and CR. CR specifically results in decreased biosynthesis of the tripeptide glutathione. (2) Lower hepatic glutathione increases the abundance of the transcription factor Nrf2, which translocates to the nucleus and ...
Sailendra N. Nichenametla +17 more
wiley +1 more source