Results 121 to 130 of about 20,779 (267)

Progress in bone tissue engineering biomaterials: Development, challenges, and prospects

VIEW, EarlyView.
Scheme 1 Application of biomaterials in immunomodulation during bone tissue engineering. Abstract Bone defect repair remains a major clinical challenge in orthopedics. Over 2 million cases caused by trauma, tumors, and other factors occur annually, with large‐scale defects posing a particular bottleneck due to limited self‐healing capacity.
Yuanbin Zhang, Junlei Chai, Quanwei Ding, Luping Liu, Kejie Zhang, Jie Lin, Jianhua Zhang, Youju Huang   +7 more
wiley   +1 more source

Health-Related Coping Behaviors Among Parents of Children with Inborn Errors of Metabolism: A Survey by Dietary Therapy, Child Age, and Diagnostic Category. [PDF]

Int J Neonatal Screen
Matsumoto Y, Kushihashi Y, Suwa A, Tajima G.   +3 more
europepmc   +1 more source

Modeling Hereditary Angioedema With Personalized EPSC‐Derived Hepatocytes: A CRISPR‐Validated Platform for Mutation‐Specific Mechanisms and Therapeutic Innovation

Allergy, EarlyView.
Patient‐derived expanded potential stem cell (EPSC) hepatocytes reveal that pathogenic SERPING1 variants cause distinct cellular defects in hereditary angioedema. While most mutations reduce SERPING1 transcription and C1‐INH secretion, a large deletion induces intracellular C1‐INH retention.
Xueyan Liu, Yuxin Wang, Jane C. Y. Wong, Xiang Zhang, Cuixi Wu, Pengyu Chen, Yunzhi Yang, Pentao Liu, Chak Sing Lau, Matthew Cook, Philip Hei Li   +10 more
wiley   +1 more source

Maternal Consumption of Artificially Sweetened Beverages in Pregnancies and Biomarkers of Fecundity in Adult Sons

Andrology, EarlyView.
ABSTRACT Introduction Maternal intake of artificial sweeteners in beverages (ASB) during pregnancy may have a programming effect on offspring health, including biomarkers of male fecundity. Objective We investigated whether maternal intake of ASB during pregnancy was associated with biomarkers of male fecundity in adult sons.
Frida Vinther Hauberg, Emilie Marquart Hviid, Mette Viola Stokholm, Anne Gaml‐Sørensen, Anne Ahrendt Bjerregaard, Thorhallur I. Halldorsson, Sandra Søgaard Tøttenborg, Cecilia Høst Ramlau‐Hansen   +7 more
wiley   +1 more source

Diagnostic and management challenges of a case of N-acetylglutamate synthase deficiency in a resource-limited healthcare setting in Tanzania: a case report. [PDF]

BMC Pediatr
Thaver S, Ebrahim M, Noorani M, Alimohamed ZM, Edward K, Furia F, Kwayu J, Fidaali Z, Abdallah Y.   +8 more
europepmc   +1 more source

Obesity Is an Independent Risk Factor for Oligozoospermia, With Co‐Existing Hyperglycemia Exacerbating Risks of Asthenozoospermia and Elevated Sperm DNA Fragmentation

Andrology, EarlyView.
ABSTRACT Background Metabolic health plays a critical role in maintaining male fertility and may influence offspring health. Therefore, it is necessary to incorporate metabolic indicators into the clinical assessment of male fertility. However, the relationships between different metabolic abnormalities and semen quality remain incompletely understood.
Rubing Hu, Haijiao Zou, Qiaodan Li, Weihong Fan, Jian Xu   +4 more
wiley   +1 more source

Alkaptonuria in two Colombian patients: identification of HGD variants including a novel finding. [PDF]

BMC Med Genomics
León-Sanabria MC, Zarante-Bahamón AM.
europepmc   +1 more source

Aniridia‐associated keratopathy: Clinical and molecular mechanisms of disease progression and emerging therapeutic targets

Acta Ophthalmologica, EarlyView.
Abstract Congenital aniridia is a rare genetic disorder primarily caused by pathogenic variants of the PAX6 gene. It leads to various panocular anomalies, including aniridia‐associated keratopathy (AAK). This review highlights recent insights into its pathogenesis, focusing on clinical staging, microstructural changes in the cornea and molecular ...
N. Szentmáry, S. Suiwal, M. Amini, F. N. Fries, A. Náray, L. Latta, Z. Li, S. Li, S. Liu, S. L. Hsu, S. Kundu, G. Tóth, S. Trusen, J. Zimmermann, B. Seitz, B. Käsmann‐Kellner, Z. Hoxha, A. Langenbucher, O. Stachs, M. Cortón‐Perez, K. Tory, A. Csorba, Z. Z. Nagy, M. C. Acosta, J. Gallar, M. Csidey, E. Maka, T. Stachon   +27 more
wiley   +1 more source

Association of maternal biliary disease with hepatopancreatobiliary morbidity in offspring. [PDF]

J Pediatr Gastroenterol Nutr
Auger N, Magri A, Kang-Auger S, Jutras G, Healy-Profitós J, Bilodeau-Bertrand M, Côté-Corriveau G.   +6 more
europepmc   +1 more source

Stable Trends in Clinical Outcomes Before Introduction of Couplet Care in a Danish Neonatal Intensive Care Unit

Acta Paediatrica, EarlyView.
ABSTRACT Aim Prior to the implementation of couplet care in 2025, knowledge of clinical outcomes was central to support feasibility and future evaluation. We aimed to review trends on mode of delivery, duration of respiratory support, nutrition at discharge and weight gain. Methods This was a descriptive register‐based study that used data from a local
Michella Bjerregaard, Anne Brødsgaard, Anna Axelin, Ingrid Poulsen, Emma Malchau Carlsen   +4 more
wiley   +1 more source