Results 51 to 60 of about 1,268 (172)

Methylglyoxal Affects Dopamine Homeostasis in SH‐SY5Y Cells Through the Modulation of miR‐190a and miR‐214

The FASEB Journal, Volume 40, Issue 5, 15 March 2026.
In SH‐SY5Y cells, Methylglyoxal (MGO) reduces the intracellular dopamine content, up‐regulating the expression of proteins that modulate dopamine amount (MAO‐B, COMT, and α‐Syn). The MGO‐induced increase of COMT and α‐Syn expression is mediated by the reduction of miR‐214 and miR‐190a levels.
Alessandra Croce, Paola Mirra, Francesca Chiara Pignalosa, Federica Zatterale, Immacolata Prevenzano, Domenico Conza, Luca Ulianich, Claudia Miele, Francesco Beguinot, Francesca Fiory   +9 more
wiley   +1 more source

Acute Effects of Transcutaneous Tibial Nerve Stimulation on Autonomic Nervous System Activity in Healthy Volunteers: An Exploratory Study

Neurourology and Urodynamics, Volume 45, Issue 3, Page 627-634, March 2026.
ABSTRACT Aim Autonomic nervous system (ANS) imbalance may contribute to functional pelvic disorders such as overactive bladder (OAB). Transcutaneous tibial nerve stimulation (TTNS) is a non‐invasive therapy for OAB; however, its autonomic modulation mechanisms remain unclear. This exploratory study evaluated the acute effects of TTNS on ANS activity in
Javier A. Muñoz, Carla Basualto‐Alarcón, Matías D. del Camino, Diego Leiva, Pablo Gálvez, Joaquín García, Gabriela Asenjo, Alfonso León, Joaquín Soto, Juan P. Valdevenito   +9 more
wiley   +1 more source

A novel mechanism of auxin habituation: upregulation of auxin receptor TRANSPORT INHIBITOR RESPONSE 1 allows cell proliferation independent of external auxin

New Phytologist, Volume 249, Issue 3, Page 1268-1282, February 2026.
Summary Exogenously applied auxins are essential for establishing cell lines in tissue cultures and maintaining their proliferation. Cell lines may develop the ability to proliferate even in media lacking auxin, they may become auxin‐habituated. This study investigated the mechanisms underlying this process.
Pavel Jelínek, Karel Müller, Eliška Kobercová, Adéla Přibylová, Milada Čovanová, Petre I. Dobrev, Roberta Vaculíková, Zuzana Vondráková, Lenka Helusová, Anita Bírošíková, Lukáš Fischer, Jan Petrášek   +11 more
wiley   +1 more source

Optimization of 4‐Amino‐2‐Pyridone Inhibitors of Proprotein Convertase Subtilisin/Kexin Type 9: Integrating Structure–Activity and Structure–Metabolism Relationships

ChemMedChem, Volume 21, Issue 1, January 2026.
Green chemistry‐based late‐stage functionalization (LSF) of the anti‐proprotein convertase subtilisin/kexin type 9 (PCSK9) early lead compound 5c led to optimized analogs with improved metabolic stability/PCSK9 IC50 ratio. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a key drug target for the treatment of different hypercholesterolemia ...
Lisa Giannessi, Maria Giovanna Lupo, Martina Ugolotti, Bianca Papotti, Beatrice Mattina, Maria Grazia Martina, Anna Demurtas, Cristina Padula, Sara Nicoli, Marco Crescenzio, Nicola Ferri, Francesca Zimetti, Marco Radi   +12 more
wiley   +1 more source

REESTRUTURAÇÃO PRODUTIVA DO CAPITAL NO CAMPO, NO SÉCULO XXI, E OS DESAFIOS PARA O TRABALHO

Revista Pegada Eletrônica, 2012
As novas territorialidades queestão sendo engendradas pelometabolismo do capital e querepercutem no processo social como um todo,especialmente para a esfera organizativa dotrabalho, é o que nos ocupa.
Antonio Thomaz Jr.
doaj   +1 more source

Factores del metabolismo social en la actividad alfarera de Metepec, México

, 2023
El estudio del metabolismo social permite comprender e identificar por medio del análisis del flujo de materia y energía las relaciones sociales emergentes; sin embargo, un factor que en la mayoría de los casos queda relegado es la dimensión social de las relaciones simbólicas (González y Toledo, 2014).
Ricardo Farfán Escalera, Carlos Alberto Pérez Ramírez, María del Carmen Torres Salazar   +2 more
openaire   +2 more sources

Obesity as a Risk Factor for Autoimmune Diseases: A Systematic Review and Meta‐Analysis

Obesity, Volume 34, Issue 1, Page 36-50, January 2026.
Summary of the meta‐analysis including 26 studies (8 cross‐sectional, 18 longitudinal) investigating the association between obesity and autoimmune diseases. Findings show increased prevalence and incidence of rheumatoid arthritis, psoriasis, multiple sclerosis, and inflammatory bowel diseases in people with obesity, suggesting that obesity may ...
Ilaria Spatocco, Giorgia Mele, Giusy De Rosa, Clorinda Fusco, Kristyna Ruggiero, Valeria Pellegrini, Francesca Carreras, Rosalba La Grotta, Antonio Ceriello, Claudio Procaccini, Giuseppe Matarese, Francesco Prattichizzo, Paola de Candia   +12 more
wiley   +1 more source

IIRSA-COSIPLAN Eje Mercosur-Chile, integración, avances e impactos. Nuevas actualizaciones en la producción social del espacio de la Zona Central de Chile

Revista de Geografía Espacios, 2019
Las transformaciones espaciales provocadas por el capital en América Latina han sido materia elemental de la disciplina geográfica y otras ciencias sociales afines.
Juan José Navarro-Martínez
doaj   +1 more source

Metabolismo social de la minería: el caso de Zacatecas (1980-2018)

Problemas del Desarrollo. Revista Latinoamericana de Economía, 2021
El presente artículo analiza el caso de la minería mexicana del estado de Zacatecas, México, a partir de la economía ecológica y la teoría del metabolismo social con un enfoque metodológico mixto. En términos cuantitativos se estimó el excedente ambiental de los principales metales a escala nacional y estatal; cualitativamente se abordaron cuatro casos
openaire   +1 more source

Scaling the effects of size and temperature on animal consumption rates from individuals to populations in a subtropical reef fish

Functional Ecology, Volume 39, Issue 12, Page 3385-3395, December 2025.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Measuring how temperature and body size drive individual consumption rates is fundamental to predict how climate change might shape population‐level consumption pressure. Yet, such measurements remain rare.
Pedro N. S. Zaú, Carlos E. L. Ferreira, Eduardo B. Fagundes Netto, Thiago C. Mendes, Diego R. Barneche   +4 more
wiley   +1 more source