Results 251 to 260 of about 527,693 (324)

Alterations of Blood Plasma Metabolites, Including Kynurenine and Tryptophan, in Bipolar Disorder. [PDF]

Neuropsychiatr Dis Treat
Nakayama T, Umehara H, Mawatari K, Tomioka Y, Yoshida T, Matsuda H, Matsumoto Y, Masuda R, Kamishikiryo T, Fuchikami M, Nakataki M, Takahashi A, Tajima A, Okada G, Numata S.   +14 more
europepmc   +1 more source

Integrative Multi‐Omics and Routine Blood Analysis Using Deep Learning: Cost‐Effective Early Prediction of Chronic Disease Risks

Advanced Science, EarlyView.
Omicsformer, a deep learning model, integrates multi‐omics and routine blood data to accurately predict risks for nine chronic diseases, including cancer and cardiovascular conditions. Validated using large scale clinical data, it reveals early risk trajectories, advancing personalized medicine and offering a cost‐effective, community‐based solution ...
Zhibin Dong, Pei Li, Yi Jiang, Zhihan Wang, Shihui Fu, Hebin Che, Meng Liu, Xiaojing Zhao, Chunlei Liu, Chenghui Zhao, Qin Zhong, Chongyou Rao, Siwei Wang, Suyuan Liu, Dayu Hu, Dongjin Wang, Juntao Gao, Kai Guo, Xinwang Liu, En Zhu, Kunlun He   +20 more
wiley   +1 more source

The Effect of Microbiome-Derived Metabolites in Inflammation-Related Cancer Prevention and Treatment. [PDF]

Biomolecules
Mafe AN, Büsselberg D.
europepmc   +1 more source

Gut Microbiota Colonization in Early Life Influences Susceptibility to Adulthood Hepatic Lipid Accumulation in High‐Fat‐Diet‐Fed Mice

Advanced Science, EarlyView.
This study indicates that perinatal antibiotic exposure elevates susceptibility to high‐fat‐diet‐induced hepatic lipid accumulation via disrupting early‐life gut microbiota colonization. The decreased Lactobacillus colonization inhibits primary‐to‐secondary bile acid conversion, lowering secondary bile acids, enhancing adulthood intestinal lipid ...
Yan‐Yan Zhu, Xin Dong, Hao Zhou, Ze‐Yan Li, Bo Wang, Ya‐Ping Song, Zhi‐Bing Liu, Xue Lu, Yi‐Hao Zhang, Yichao Huang, Hua Wang, De‐Xiang Xu   +11 more
wiley   +1 more source

A Simulation Study of the Metabolism and Compartmentation in Brain of Glutamate, Aspartate, the Krebs Cycle, and Related Metabolites

, 1966
David Garfinkel
openalex   +1 more source

Evaluating parameter selection and analysis approaches on quality and reproducibility of functional MRS

Pasanta D, Lythgoe DJ, Puts NA.
europepmc   +1 more source

Metabolic characteristics of benign and malignant pulmonary nodules and establishment of invasive lung adenocarcinoma model by high-resolution mass spectrometry. [PDF]

BMC Cancer
Zhang J, Zhang Z, Liu Y, Hou Y, Pang R, Wang Y, Xu P.   +6 more
europepmc   +1 more source

Tailoring a Functional Synthetic Microbial Community Alleviates Fusobacterium nucleatum‐infected Colorectal Cancer via Ecological Control

Advanced Science, EarlyView.
The bottom‐up strategy based on multiomics data is used for the SynCom design, and it successfully inhibited F. nucleatum growth and achieved stable colonization in vivo. In addition, it promoted tryptophan metabolism and secondary bile acid conversion, reduced lipid accumulation, relieved microbiome disorder, decreased inflammatory reaction, and ...
Zhongkun Zhou, Mengyue Yang, Hong Fang, Baizhuo Zhang, Yunhao Ma, Yongyuan Li, Yingjie Liu, Zeying Cheng, Yuanchun Zhao, Zhenzhen Si, Hongmei Zhu, Peng Chen   +11 more
wiley   +1 more source

Metabolism of Indoleacetic Acid in Rust Diseases. II. Metabolites of Carboxyl-labeled Indoleacetic Acid in Tissues

, 1964
B.J. Deverall, J.M. Daly
openalex   +2 more sources

Perturbation-response analysis of in silico metabolic dynamics revealed hard-coded responsiveness in the cofactors and network sparsity. [PDF]

Elife
Himeoka Y, Furusawa C.
europepmc   +1 more source