Results 341 to 350 of about 1,686,019 (401)
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Protoplasma, 1967
Transport phenomena have a fundamental role in cellular activity. The evidence of a limiting barrier is given by the fact that the content of living cells differs from that of the medium. In most cases the concentration of K+ in the cell is ten or more times higher than that of Na+, even in cells immersed in a medium where Na+ concentration exceeds K+.
E, Tria, O, Barnabei
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Transport phenomena have a fundamental role in cellular activity. The evidence of a limiting barrier is given by the fact that the content of living cells differs from that of the medium. In most cases the concentration of K+ in the cell is ten or more times higher than that of Na+, even in cells immersed in a medium where Na+ concentration exceeds K+.
E, Tria, O, Barnabei
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A Metabolite Array Technology for Precision Medicine.
Analytical Chemistry, 2021The application of metabolomics in translational research suffers from several technological bottlenecks, such as data reproducibility issues and the lack of standardization of sample profiling procedures.
G. Xie +14 more
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Metabolites of Demoxepam, a Chlordiazepoxide Metabolite, in Man
Journal of Pharmaceutical Sciences, 1972The biotransformation of demoxepam, 7-chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one 4-oxide, was studied in two subjects. Following the administration of a 20-mg. oral dose of demoxepam-2-14C, these subjects excreted 24 and 29% of the dose in the urine as unchanged drug. The urinary metabolites included “opened lactam” (formed by hydrolysis of
M A, Schwartz, E, Postma
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Clinical Toxicology, 1976
The results of the animal experiment demonstrate that oxidative hydroxylation is the major mode of metabolism of phencyclidine. It is evident that this process takes place in all three rings of the molecule. Hydroxylation of the piperidyl moiety probably also accounts for the formation of the N-dealkylated metabolites.
L K, Wong, K, Biemann
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The results of the animal experiment demonstrate that oxidative hydroxylation is the major mode of metabolism of phencyclidine. It is evident that this process takes place in all three rings of the molecule. Hydroxylation of the piperidyl moiety probably also accounts for the formation of the N-dealkylated metabolites.
L K, Wong, K, Biemann
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2017
This handbook compiles authoritative information about fungal metabolites and their chemistry and biotechnology. The first in the reference work series “Phytochemicals”, and written by a team of international expert authors, this book provides reference information ranging from the description of fungal natural products, over their use e.g.
Merillon, Jean-Michel +1 more
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This handbook compiles authoritative information about fungal metabolites and their chemistry and biotechnology. The first in the reference work series “Phytochemicals”, and written by a team of international expert authors, this book provides reference information ranging from the description of fungal natural products, over their use e.g.
Merillon, Jean-Michel +1 more
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Journal of Pharmaceutical Sciences, 1974
Microbial transformation of the alkaloid mitragynine by the fungus Helminthosporum sp. has elaborated two major metabolites. The compounds were isolated from the biological milieu and their structures were elucidated as mitragynine pseudoindoxyl and hydroxy mitragynine pseudoindoxyl.
J E, Zarembo +3 more
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Microbial transformation of the alkaloid mitragynine by the fungus Helminthosporum sp. has elaborated two major metabolites. The compounds were isolated from the biological milieu and their structures were elucidated as mitragynine pseudoindoxyl and hydroxy mitragynine pseudoindoxyl.
J E, Zarembo +3 more
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Catecholamines and their metabolites
Journal of Chromatography B: Biomedical Sciences and Applications, 1988The research on biosynthesis, physiology, pharmacology, regulation and degradation of catecholamines has continuously increased for more than 50 years. This is not unexpected because of the fact that catecholamines are involved in so many life processes such as nerve conduction, blood circulation and hormone regulations in health and disease.
B, Kågedal, D S, Goldstein
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Current Opinion in Microbiology, 1993
The extraordinary chemical diversity seen in the cyanobacteria (blue-green algae) is especially pronounced in the ubiquitous tropical marine species, Lyngbya majuscula. The gene clusters responsible for the production of some of the secondary metabolites have recently been elucidated.
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The extraordinary chemical diversity seen in the cyanobacteria (blue-green algae) is especially pronounced in the ubiquitous tropical marine species, Lyngbya majuscula. The gene clusters responsible for the production of some of the secondary metabolites have recently been elucidated.
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Acta Anaesthesiologica Scandinavica, 1997
Morphine is a potent opioid analgesic widely used for the treatment of acute pain and for long‐term treatment of severe pain. Morphine is a member of the morphinan‐framed alkaloids, which are present in the poppy plant. The drug is soluble in water, but its solubility in lipids is poor.In man, morphine‐3‐glucuronide (M3G) and morphine‐6‐glucu‐ronide ...
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Morphine is a potent opioid analgesic widely used for the treatment of acute pain and for long‐term treatment of severe pain. Morphine is a member of the morphinan‐framed alkaloids, which are present in the poppy plant. The drug is soluble in water, but its solubility in lipids is poor.In man, morphine‐3‐glucuronide (M3G) and morphine‐6‐glucu‐ronide ...
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Metabolite Damage and Metabolite Damage Control in Plants
Annual Review of Plant Biology, 2016It is increasingly clear that (a) many metabolites undergo spontaneous or enzyme-catalyzed side reactions in vivo, (b) the damaged metabolites formed by these reactions can be harmful, and (c) organisms have biochemical systems that limit the buildup of damaged metabolites.
Andrew D, Hanson +3 more
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