Results 131 to 140 of about 422,605 (335)

Metabolite changes in blood predict the onset of tuberculosis

, 2018
Immunogenetics and cellular immunology of bacterial infectious ...
Boom, W.H., Dockrell, H.M., Duffy, F.J., GC6-74 Consortium, Hanekom, W.A., Howe, R., Kaufmann, S.H.E., Maertzdorf, J., Mayanja-Kizza, H., McEwen, G., Mohney, R.P., Ottenhoff, T.H.M., Parida, S.K., Scriba, T.J., Suliman, S., Sutherland, J.S., Thiel, B., Thompson, E., Walzl, G., Weiner, J., Zak, D.E., Zyla, J.   +21 more
core   +1 more source

Farnesyltransferase Deficiency in Cardiomyocytes Initiates Senescence and Contributes to Cardiac Fibrosis

Advanced Science, EarlyView.
Lipid overload suppresses SREBF2‐mediated FNTB expression, leading to defective Lamin A maturation and nuclear envelope instability. This nuclear catastrophe triggers a pro‐fibrotic senescence program in cardiomyocytes. Notably, restoring nuclear integrity via AAV9‐based gene therapy effectively attenuates cardiac remodeling, identifying the ...
Yuxiao Chen, Lian Lou, Xuan Zhang, Lin Yan, Qi Zhang, Wen Shi, Jie Ding, Xu Lin, Rong Jiang, Shuo Liu, Thida Sok, Pengli Wang, Yun Mou, Jie Han, Shenjiang Hu, Xiaogang Guo, Jian Yang   +16 more
wiley   +1 more source

Mass spectrometry-based metabolomics: a guide for annotation, quantification and best reporting practices

Nature Methods, 2021
S. Alseekh, A. Aharoni, Y. Brotman, K. Contrepois, J. D’Auria, Jan Ewald, Jennifer C Ewald, P. Fraser, Patrick Giavalisco, R. Hall, Matthias Heinemann, H. Link, Jie Luo, S. Neumann, J. Nielsen, Leonardo Perez de Souza, K. Saito, U. Sauer, F. Schroeder, S. Schuster, G. Siuzdak, A. Skirycz, L. Sumner, M. Snyder, Huiru Tang, Takayuki Tohge, Yulan Wang, Weiwei Wen, Si Wu, Guowang Xu, Nicola Zamboni, A. Fernie   +31 more
semanticscholar   +1 more source

Integrated Single‐Cell and Spatial Transcriptomics Reveal Cell‐Type‐Specific Immune Regulatory Networks in Maize Responding to Southern Corn Rust

Advanced Science, EarlyView.
By integrating single‐nuclei and spatial transcriptomics, this study presents a stereoscopic landscape of maize leaf to Puccinia polysora infection. Epidermal and mesophyll cells initiate primary defenses via RLPs/RLKs and jasmonic acid signaling. Cell‐cell communication analyses further reveal the underlying the dynamics of the underlying immune ...
Qiongqiong Wang, Xinyan Sun, Yingchao Sun, Zeqiang Cheng, Zixiang Cheng, Shengbo Han, Ying Feng, Wenbo Yang, Huimin Li, Meichen Zhu, Xiaoling Wu, Jinghua Zhang, Jihua Tang, Honglian Li, Yanyong Cao, Canxing Duan, Yan Shi   +16 more
wiley   +1 more source

The future of NMR-based metabolomics.

Current Opinion in Biotechnology, 2017
The two leading analytical approaches to metabolomics are mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy. Although currently overshadowed by MS in terms of numbers of compounds resolved, NMR spectroscopy offers advantages both ...
J. Markley, R. Brüschweiler, A. Edison, H. Eghbalnia, R. Powers, D. Raftery, D. Wishart   +6 more
semanticscholar   +1 more source

Single‐Cell Metabolic Imaging and Digital Scoring of Fat Tissue Remodeling by Label‐Free Metabolic Microscopy

Advanced Science, EarlyView.
Mid‐infrared optoacoustic microscopy (MiROM) acquires lipid‐ and protein‐ associated vibrational contrast in intact fat tissue without dyes, preserving native tissue architecture. Through lateral and axial segmentation, MiROM tracks intrinsic intracellular changes during postnatal remodeling. A quantitative spatial analysis tool (Q‐SAT) maps white‐ and
Myeongseop Kim, Constantin Berger, Alexander Wolf, Alina Peteranderl, Martin Klingenspor, Vasilis Ntziachristos, Yongguo Li, Miguel A. Pleitez   +7 more
wiley   +1 more source

Obesity in breast cancer patients after oncological treatment. How to conduct a nutritional intervention?

Nowotwory
Obesity in breast cancer patients is a significant predictor of morbidity as well as adverse treatment outcomes. It correlates with poorer response to treatment, particularly affecting survival length and quality of life.
Nikola Janowska, Agata Łyczek, Natalia Komorniak, Natalia Jakubiak, Karolina Siedlecka-Kaźmierczak, Ewa Stachowska   +5 more
doaj   +1 more source

Paving the Way to Elucidate Hg's Role in Tumorigenesis

Advanced Science, EarlyView.
Tumorigenesis can result from diverse environmental carcinogens. Among them, mercury—a lifelong bioaccumulative Group 2B carcinogen—has tumorigenic potential that remains poorly understood due to confounding co‐exposures and limited organ‐specific data.
Shouying Li, Rong Zhong, Zhenyang Yu, Hualing Fu, Jin Chen, Jia Wei, Ningwei Zhao, Le Qu, Tiantian Li, Wenli Tang, Huan Zhong   +10 more
wiley   +1 more source

Epigenetic anticancer agents cause HMGB1 release in vivo

OncoImmunology, 2018
A systematic search for anticancer agents that may induce the release of high mobility group box 1 (HMGB1) protein from cells into the extracellular space has led to the identification of several drugs capable of elevating plasma HMGB1 levels in vivo, in
Peng Liu, Liwei Zhao, Friedemann Loos, Kristina Iribarren, Oliver Kepp, Guido Kroemer   +5 more
doaj   +1 more source

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source