Results 1 to 10 of about 51,880 (241)
Metabotropic glutamate receptor 1 (Grm1) is an oncogene in epithelial cells [PDF]
Oncogene, 2012 Non-neuronal expression of components of the glutamatergic system has been increasingly observed, and our laboratory previously had demonstrated the etiological role of ectopically expressed metabotropic glutamate receptor 1 (Grm1/mGluR1) in mouse models of melanoma.
Jeffrey J. Martino +7 more
europepmc +4 more sources
Metabotropic Glutamate Receptor-1 Contributes to Progression in Triple Negative Breast Cancer [PDF]
PLoS ONE, 2014 TNBC is an aggressive breast cancer subtype that does not express hormone receptors (estrogen and progesterone receptors, ER and PR) or amplified human epidermal growth factor receptor type 2 (HER2), and there currently exist no targeted therapies effective against it.
Malathi Banda +11 more
europepmc +7 more sources
Activation of Metabotropic Glutamate Receptor 1 Accelerates NMDA Receptor Trafficking [PDF]
The Journal of Neuroscience, 2001 Regulation of neuronal NMDA receptors (NMDARs) by group I metabotropic glutamate receptors (mGluRs) is known to play a critical role in synaptic transmission. The molecular mechanisms underlying mGluR1-mediated potentiation of NMDARs are as yet unclear.
Jian-yu Lan +5 more
openalex +4 more sources
Metabotropic Glutamate Receptors, PLCbeta 1 Signalling and Hippocampal Epileptiform Discharges [PDF]
Epilepsy Currents, 2002 Group I Metabotropic Glutamate Receptors Elicit Epileptiform Discharges in the Hippocampus Through PLCbeta1 Signaling Chuang SC, Bianchi R, Kim D, Shin HS, Wong RK J Neurosci 2001;21:6387–6394 Activation of metabotropic glutamate receptors (mGluRs) produces multiple effects in cortical neurons, resulting in the emergence of network activities ...
Larry S. Benardo
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Metabotropic Glutamate Receptor 1 and Glutamate Signaling in Human Melanoma [PDF]
Cancer Research, 2007 Abstract Recently, several laboratories have started to investigate the involvement of glutamate signaling in cancer. In previous studies, we reported on a transgenic mouse model that develops melanoma spontaneously. Subsequent studies in these mice identified that the aberrant expression of metabotropic glutamate receptor 1 (GRM1) in ...
Jin Namkoong +6 more
openalex +5 more sources
Metabotropic glutamate receptor type 1 in taste tissue [PDF]
The American Journal of Clinical Nutrition, 2009 l-Glutamate confers cognitive discrimination for umami taste (delicious or savory) and dietary information to the brain through the activation of G protein-coupled receptors in specialized taste receptor cells of the tongue. The taste heterologous receptor T1R1 plus T1R3 is not sufficient to detect umami taste in mice.
Ana San Gabriel +3 more
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Negative Cooperativity of Glutamate Binding in the Dimeric Metabotropic Glutamate Receptor Subtype 1 [PDF]
Journal of Biological Chemistry, 2004 Metabotropic glutamate receptor (mGluR) subtype 1 is a Class III G-protein-coupled receptor that is mainly expressed on the post-synaptic membrane of neuronal cells. The receptor has a large N-terminal extracellular ligand binding domain that forms a homodimer, however, the intersubunit communication of ligand binding in the dimer remains unknown. Here,
Yoshikazu Suzuki +3 more
openalex +5 more sources
Cys-140 Is Critical for Metabotropic Glutamate Receptor-1 Dimerization [PDF]
Journal of Biological Chemistry, 2000 Metabotropic glutamate receptor 1 (mGluR1) expresses at the cell surface as disulfide-linked dimers and can be reduced to monomers with sulfhydryl reagents. To identify the dimerization domain, we transiently expressed in HEK-293 cells a truncated version of mGluR1 (RhodC-R1) devoid of the extracellular domain (ECD).
Kausik K. Ray, Benjamin C. Hauschild
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Cholesterol Dependence of the Conformational Changes in Metabotropic Glutamate Receptor 1 [PDF]
AbstractMetabotropic glutamate receptors (mGluRs) are class C G protein-coupled receptors that function as obligate dimers in regulating neurotransmission and synaptic plasticity in the central nervous system. The mGluR1 subtype has been shown to be modulated by the membrane lipid environment, particularly cholesterol, though the molecular mechanisms ...
Ugochi H. Isu +5 more
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GRM1 (glutamate receptor, metabotropic 1) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2014 Review on GRM1, with data on DNA/RNA, on the protein encoded and where the gene is implicated.
Sierra, J, Chen, S
openaire +2 more sources