Results 1 to 10 of about 55,499 (288)

AgRP/NPY Neuron Excitability Is Modulated by Metabotropic Glutamate Receptor 1 During Fasting. [PDF]

Front Cell Neurosci, 2018
The potential to control feeding behavior via hypothalamic AgRP/NPY neurons has led to many approaches to modulate their excitability—particularly by glutamatergic input.
Laing BT, Li P, Schmidt CA, Bunner W, Yuan Y, Landry T, Prete A, McClung JM, Huang H.   +8 more
europepmc   +5 more sources

Metabotropic glutamate receptor 1 (Grm1) is an oncogene in epithelial cells. [PDF]

Oncogene, 2013
Non-neuronal expression of components of the glutamatergic system has been increasingly observed, and our laboratory previously had demonstrated the etiological role of ectopically expressed metabotropic glutamate receptor 1 (Grm1/mGluR1) in mouse models of melanoma.
Martino JJ, Wall BA, Mastrantoni E, Wilimczyk BJ, La Cava SN, Degenhardt K, White E, Chen S.   +7 more
europepmc   +6 more sources

Glycine Release Is Upregulated by Metabotropic Glutamate Receptor 1 in Mouse Hippocampus. [PDF]

Biomedicines
Background/Objectives: The neurotransmitter glycine is involved in several physiological and pathological conditions in the Central Nervous System. Different biological structures, including glycine receptors and transporters, are under study as targets ...
Raiteri L, Cerminara M, Puliti A, Pittaluga A.   +3 more
europepmc   +2 more sources

Knocking down metabotropic glutamate receptor 1 improves survival and disease progression in the SOD1G93A mouse model of amyotrophic lateral sclerosis

Neurobiology of Disease, 2013
Amyotrophic lateral sclerosis (ALS) is a late-onset fatal neurodegenerative disease reflecting degeneration of upper and lower motoneurons (MNs).
Marco Milanese, Francesco Giribaldi, Marcello Melone, Tiziana Bonifacino, Ilaria Musante, Enrico Carminati, Pia Rossi, Laura Vergani, Adriana Voci, Fiorenzo Conti, Aldamaria Puliti, Giambattista Bonanno   +11 more
openalex   +3 more sources

Mutations in Metabotropic Glutamate Receptor 1 Contribute to Natural Short Sleep Trait. [PDF]

Curr Biol, 2021
Sufficient and efficient sleep is crucial for our health. Natural short sleepers can sleep significantly shorter than the average population without a desire for more sleep and without any obvious negative health consequences. In searching for genetic variants underlying the short sleep trait, we found two different mutations in the same gene ...
Shi G, Yin C, Fan Z, Xing L, Mostovoy Y, Kwok PY, Ashbrook LH, Krystal AD, Ptáček LJ, Fu YH.   +9 more
europepmc   +6 more sources

Metabotropic glutamate receptor-1 regulates inflammation in triple negative breast cancer. [PDF]

Sci Rep, 2018
AbstractBreast cancer remains a major cause of death among women. 15% of these cancers are triple negative breast cancer (TNBC), an aggressive subtype of breast cancer for which no current effective targeted therapy exists. We have previously demonstrated a role for mGluR1 in mediating tumor cell growth, endothelial cell proliferation, and tumor ...
Sexton RE, Hachem AH, Assi AA, Bukhsh MA, Gorski DH, Speyer CL.   +5 more
europepmc   +4 more sources

Negative Cooperativity of Glutamate Binding in the Dimeric Metabotropic Glutamate Receptor Subtype 1 [PDF]

Journal of Biological Chemistry, 2004
Metabotropic glutamate receptor (mGluR) subtype 1 is a Class III G-protein-coupled receptor that is mainly expressed on the post-synaptic membrane of neuronal cells. The receptor has a large N-terminal extracellular ligand binding domain that forms a homodimer, however, the intersubunit communication of ligand binding in the dimer remains unknown. Here,
Yoshikazu Suzuki, Eiko Moriyoshi, Daisuke Tsuchiya, Hisato Jingami   +3 more
openalex   +4 more sources

Glutamate Delta-1 Receptor Regulates Metabotropic Glutamate Receptor 5 Signaling in the Hippocampus [PDF]

Molecular Pharmacology, 2016
The delta family of ionotropic glutamate receptors consists of glutamate delta-1 (GluD1) and glutamate delta-2 receptors. We have previously shown that GluD1 knockout mice exhibit features of developmental delay, including impaired spine pruning and switch in the N-methyl-D-aspartate receptor subunit, which are relevant to autism and other ...
Pratyush Suryavanshi, Subhash C. Gupta, Roopali Yadav, Varun Kesherwani, Jinxu Liu, Shashank M. Dravid   +5 more
openalex   +3 more sources

Metabotropic Glutamate Receptors, PLCbeta 1 Signalling and Hippocampal Epileptiform Discharges [PDF]

Epilepsy Currents, 2002
Group I Metabotropic Glutamate Receptors Elicit Epileptiform Discharges in the Hippocampus Through PLCbeta1 Signaling Chuang SC, Bianchi R, Kim D, Shin HS, Wong RK J Neurosci 2001;21:6387–6394 Activation of metabotropic glutamate receptors (mGluRs) produces multiple effects in cortical neurons, resulting in the emergence of network activities ...
Larry S. Benardo
openalex   +4 more sources

Metabotropic glutamate receptor 1 is associated with unfavorable prognosis in ER-negative and triple-negative breast cancer. [PDF]

Sci Rep, 2020
New therapies are an urgent medical need in all breast cancer subgroups. Metabotropic glutamate receptor 1 (mGluR1) is suggested as a potential new molecular target.
Bastiaansen AEM, Timmermans AM, Smid M, van Deurzen CHM, Hulsenboom ESP, Prager-van der Smissen WJC, Foekens R, Trapman-Jansen AMAC, Sillevis Smitt PAE, Luider TM, Martens JWM, vanDuijn MM.   +11 more
europepmc   +2 more sources