Results 1 to 10 of about 56,166 (223)

AgRP/NPY Neuron Excitability Is Modulated by Metabotropic Glutamate Receptor 1 During Fasting [PDF]

Frontiers in Cellular Neuroscience, 2018
The potential to control feeding behavior via hypothalamic AgRP/NPY neurons has led to many approaches to modulate their excitability—particularly by glutamatergic input.
Brenton T. Laing, Brenton T. Laing, Peixin Li, Peixin Li, Cameron A. Schmidt, Cameron A. Schmidt, Wyatt Bunner, Wyatt Bunner, Yuan Yuan, Yuan Yuan, Taylor Landry, Taylor Landry, Amber Prete, Joseph M. McClung, Joseph M. McClung, Hu Huang, Hu Huang, Hu Huang   +17 more
doaj   +4 more sources

Metabotropic glutamate receptor-1 contributes to progression in triple negative breast cancer. [PDF]

PLoS ONE, 2014
TNBC is an aggressive breast cancer subtype that does not express hormone receptors (estrogen and progesterone receptors, ER and PR) or amplified human epidermal growth factor receptor type 2 (HER2), and there currently exist no targeted therapies ...
Malathi Banda, Cecilia L Speyer, Sara N Semma, Kingsley O Osuala, Nicole Kounalakis, Keila E Torres Torres, Nicola J Barnard, Hyunjin J Kim, Bonnie F Sloane, Fred R Miller, James S Goydos, David H Gorski   +11 more
doaj   +3 more sources

Concurrent Targeting of Glutaminolysis and Metabotropic Glutamate Receptor 1 (GRM1) Reduces Glutamate Bioavailability in GRM1⁺ Melanoma. [PDF]

Cancer Res, 2019
Aberrant glutamatergic signaling has been implicated in altered metabolic activity in many cancer types, including malignant melanoma. Previously, we have illustrated the role of metabotropic glutamate receptor 1 (GRM1) in neoplastic transformation of ...
Shah R, Singh SJ, Eddy K, Filipp FV, Chen S.   +4 more
europepmc   +4 more sources

Metabotropic glutamate receptor-1 as a novel target for the antiangiogenic treatment of breast cancer. [PDF]

PLoS ONE, 2014
Metabotropic glutamate receptors (mGluRs) are normally expressed in the central nervous system, where they mediate neuronal excitability and neurotransmitter release.
Cecilia L Speyer, Ali H Hachem, Ali A Assi, Jennifer S Johnson, John A DeVries, David H Gorski   +5 more
doaj   +3 more sources

Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator. [PDF]

Science, 2014
Wu H, Wang C, Gregory KJ, Han GW, Cho HP, Xia Y, Niswender CM, Katritch V, Meiler J, Cherezov V, Conn PJ, Stevens RC.   +11 more
europepmc   +3 more sources

Metabotropic glutamate receptor 1 (Grm1) is an oncogene in epithelial cells. [PDF]

Oncogene, 2013
Non-neuronal expression of components of the glutamatergic system has been increasingly observed, and our laboratory previously had demonstrated the etiological role of ectopically expressed metabotropic glutamate receptor 1 (Grm1/mGluR1) in mouse models
Martino JJ, Wall BA, Mastrantoni E, Wilimczyk BJ, La Cava SN, Degenhardt K, White E, Chen S.   +7 more
europepmc   +4 more sources

Knocking down metabotropic glutamate receptor 1 improves survival and disease progression in the SOD1G93A mouse model of amyotrophic lateral sclerosis

Neurobiology of Disease, 2014
Amyotrophic lateral sclerosis (ALS) is a late-onset fatal neurodegenerative disease reflecting degeneration of upper and lower motoneurons (MNs).
Marco Milanese, Francesco Giribaldi, Marcello Melone, Tiziana Bonifacino, Ilaria Musante, Enrico Carminati, Pia I.A. Rossi, Laura Vergani, Adriana Voci, Fiorenzo Conti, Aldamaria Puliti, Giambattista Bonanno   +11 more
doaj   +2 more sources

Metabotropic glutamate receptor 1 is associated with unfavorable prognosis in ER-negative and triple-negative breast cancer [PDF]

Scientific Reports, 2020
New therapies are an urgent medical need in all breast cancer subgroups. Metabotropic glutamate receptor 1 (mGluR1) is suggested as a potential new molecular target.
Anna E. M. Bastiaansen, A. Mieke Timmermans, Marcel Smid, Carolien H. M. van Deurzen, Esther S. P. Hulsenboom, Wendy J. C. Prager-van der Smissen, Renée Foekens, Anita M. A. C. Trapman-Jansen, Peter A. E. Sillevis Smitt, Theo M. Luider, John W. M. Martens, Martijn M. vanDuijn   +11 more
doaj   +2 more sources

Anticancer effect of HOTTIP regulates human pancreatic cancer via the metabotropic glutamate receptor 1 pathway. [PDF]

Oncol Lett, 2018
Ye Y, Li Y, Wei Y, Xu Y, Wang R, Fu Z, Zheng S, Zhou Q, Zhou Y, Chen R, Chen T.   +10 more
europepmc   +3 more sources

Anti-mGluR1 encephalitis: Case illustration and systematic review

Frontiers in Neurology, 2023
BackgroundThe literature for immune-mediated neurological disorders is evolving like no other field of neurological illnesses. Many new antibodies or disorders have been described in the last decade.
Osama Khojah, Osama Khojah, Osama Khojah, Seraj Makkawi, Seraj Makkawi, Seraj Makkawi, Saeed Alghamdi   +6 more
doaj   +1 more source