Metabotropic glutamate receptor-1 contributes to progression in triple negative breast cancer. [PDF]
PLoS ONE, 2014 TNBC is an aggressive breast cancer subtype that does not express hormone receptors (estrogen and progesterone receptors, ER and PR) or amplified human epidermal growth factor receptor type 2 (HER2), and there currently exist no targeted therapies ...
Malathi Banda +11 more
doaj +7 more sources
Metabotropic glutamate receptor 1 (Grm1) is an oncogene in epithelial cells. [PDF]
Oncogene, 2013 Non-neuronal expression of components of the glutamatergic system has been increasingly observed, and our laboratory previously had demonstrated the etiological role of ectopically expressed metabotropic glutamate receptor 1 (Grm1/mGluR1) in mouse models of melanoma.
Martino JJ +7 more
europepmc +5 more sources
Metabotropic glutamate receptor-1 as a novel target for the antiangiogenic treatment of breast cancer. [PDF]
PLoS ONE, 2014 Metabotropic glutamate receptors (mGluRs) are normally expressed in the central nervous system, where they mediate neuronal excitability and neurotransmitter release.
Cecilia L Speyer +5 more
doaj +6 more sources
Activation of Metabotropic Glutamate Receptor 1 Accelerates NMDA Receptor Trafficking [PDF]
The Journal of Neuroscience, 2001 Regulation of neuronal NMDA receptors (NMDARs) by group I metabotropic glutamate receptors (mGluRs) is known to play a critical role in synaptic transmission. The molecular mechanisms underlying mGluR1-mediated potentiation of NMDARs are as yet unclear.
Vytenis Arvydas Skeberdis +5 more
openaire +4 more sources
AgRP/NPY Neuron Excitability Is Modulated by Metabotropic Glutamate Receptor 1 During Fasting [PDF]
Frontiers in Cellular Neuroscience, 2018 The potential to control feeding behavior via hypothalamic AgRP/NPY neurons has led to many approaches to modulate their excitability—particularly by glutamatergic input.
Brenton T. Laing +17 more
doaj +2 more sources
Metabotropic Glutamate Receptors, PLCbeta 1 Signalling and Hippocampal Epileptiform Discharges [PDF]
Epilepsy Currents, 2002 Group I Metabotropic Glutamate Receptors Elicit Epileptiform Discharges in the Hippocampus Through PLCbeta1 Signaling Chuang SC, Bianchi R, Kim D, Shin HS, Wong RK J Neurosci 2001;21:6387–6394 Activation of metabotropic glutamate receptors (mGluRs) produces multiple effects in cortical neurons, resulting in the emergence of network activities ...
Larry S. Benardo
openaire +4 more sources
Metabotropic Glutamate Receptor 1 and Glutamate Signaling in Human Melanoma [PDF]
Cancer Research, 2007 Abstract Recently, several laboratories have started to investigate the involvement of glutamate signaling in cancer. In previous studies, we reported on a transgenic mouse model that develops melanoma spontaneously. Subsequent studies in these mice identified that the aberrant expression of metabotropic glutamate receptor 1 (GRM1) in ...
Hwa Jin Lee +6 more
openaire +5 more sources
Metabotropic glutamate receptor type 1 in taste tissue [PDF]
The American Journal of Clinical Nutrition, 2009 l-Glutamate confers cognitive discrimination for umami taste (delicious or savory) and dietary information to the brain through the activation of G protein-coupled receptors in specialized taste receptor cells of the tongue. The taste heterologous receptor T1R1 plus T1R3 is not sufficient to detect umami taste in mice.
Hisayuki Uneyama +3 more
openaire +4 more sources
Negative Cooperativity of Glutamate Binding in the Dimeric Metabotropic Glutamate Receptor Subtype 1 [PDF]
Journal of Biological Chemistry, 2004 Metabotropic glutamate receptor (mGluR) subtype 1 is a Class III G-protein-coupled receptor that is mainly expressed on the post-synaptic membrane of neuronal cells. The receptor has a large N-terminal extracellular ligand binding domain that forms a homodimer, however, the intersubunit communication of ligand binding in the dimer remains unknown. Here,
Eiko Moriyoshi +3 more
openaire +5 more sources
Metabotropic glutamate receptor 1 is associated with unfavorable prognosis in ER-negative and triple-negative breast cancer [PDF]
Scientific Reports, 2020 New therapies are an urgent medical need in all breast cancer subgroups. Metabotropic glutamate receptor 1 (mGluR1) is suggested as a potential new molecular target.
Anna E. M. Bastiaansen +11 more
doaj +2 more sources