Results 1 to 10 of about 592,134 (284)

Metabotropic glutamate receptor-1 contributes to progression in triple negative breast cancer. [PDF]

PLoS ONE, 2014
TNBC is an aggressive breast cancer subtype that does not express hormone receptors (estrogen and progesterone receptors, ER and PR) or amplified human epidermal growth factor receptor type 2 (HER2), and there currently exist no targeted therapies ...
Malathi Banda, Cecilia L Speyer, Sara N Semma, Kingsley O Osuala, Nicole Kounalakis, Keila E Torres Torres, Nicola J Barnard, Hyunjin J Kim, Bonnie F Sloane, Fred R Miller, James S Goydos, David H Gorski   +11 more
doaj   +8 more sources

Metabotropic glutamate receptor-1 as a novel target for the antiangiogenic treatment of breast cancer. [PDF]

PLoS ONE, 2014
Metabotropic glutamate receptors (mGluRs) are normally expressed in the central nervous system, where they mediate neuronal excitability and neurotransmitter release.
Cecilia L Speyer, Ali H Hachem, Ali A Assi, Jennifer S Johnson, John A DeVries, David H Gorski   +5 more
doaj   +7 more sources

Metabotropic glutamate receptor 1 (Grm1) is an oncogene in epithelial cells. [PDF]

Oncogene, 2013
Non-neuronal expression of components of the glutamatergic system has been increasingly observed, and our laboratory previously had demonstrated the etiological role of ectopically expressed metabotropic glutamate receptor 1 (Grm1/mGluR1) in mouse models of melanoma.
Martino JJ, Wall BA, Mastrantoni E, Wilimczyk BJ, La Cava SN, Degenhardt K, White E, Chen S.   +7 more
europepmc   +6 more sources

Glutamate secretion and metabotropic glutamate receptor 1 expression during Kaposi's sarcoma-associated herpesvirus infection promotes cell proliferation. [PDF]

PLoS Pathogens, 2014
Kaposi's sarcoma associated herpesvirus (KSHV) is etiologically associated with endothelial Kaposi's sarcoma (KS) and B-cell proliferative primary effusion lymphoma (PEL), common malignancies seen in immunocompromised HIV-1 infected patients.
Mohanan Valiya Veettil, Dipanjan Dutta, Virginie Bottero, Chirosree Bandyopadhyay, Olsi Gjyshi, Neelam Sharma-Walia, Sujoy Dutta, Bala Chandran   +7 more
doaj   +4 more sources

Concurrent Targeting of Glutaminolysis and Metabotropic Glutamate Receptor 1 (GRM1) Reduces Glutamate Bioavailability in GRM1⁺ Melanoma. [PDF]

Cancer Res, 2019
Aberrant glutamatergic signaling has been implicated in altered metabolic activity in many cancer types, including malignant melanoma. Previously, we have illustrated the role of metabotropic glutamate receptor 1 (GRM1) in neoplastic transformation of ...
Shah R, Singh SJ, Eddy K, Filipp FV, Chen S.   +4 more
europepmc   +2 more sources

Exosomes released by metabotropic glutamate receptor 1 (GRM1) expressing melanoma cells increase cell migration and invasiveness. [PDF]

Oncotarget, 2018
Exosomes are naturally occurring membrane-bound nanovesicles generated constitutively and released by various cell types, and often in higher quantities by tumor cells.
Isola AL, Eddy K, Zembrzuski K, Goydos JS, Chen S.   +4 more
europepmc   +2 more sources

Metabotropic glutamate receptor 1 disrupts mammary acinar architecture and initiates malignant transformation of mammary epithelial cells. [PDF]

Breast Cancer Res Treat, 2015
Teh JL, Shah R, La Cava S, Dolfi SC, Mehta MS, Kongara S, Price S, Ganesan S, Reuhl KR, Hirshfield KM, Karantza V, Chen S.   +11 more
europepmc   +4 more sources

Riluzole exerts distinct antitumor effects from a metabotropic glutamate receptor 1-specific inhibitor on breast cancer cells. [PDF]

Oncotarget, 2017
Recent evidence suggests that glutamate signaling plays an important role in cancer. Riluzole is a glutamate release inhibitor and FDA-approved drug for the treatment of amyotrophic lateral sclerosis.
Dolfi SC, Medina DJ, Kareddula A, Paratala B, Rose A, Dhami J, Chen S, Ganesan S, Mackay G, Vazquez A, Hirshfield KM.   +10 more
europepmc   +2 more sources

AgRP/NPY Neuron Excitability Is Modulated by Metabotropic Glutamate Receptor 1 During Fasting [PDF]

Frontiers in Cellular Neuroscience, 2018
The potential to control feeding behavior via hypothalamic AgRP/NPY neurons has led to many approaches to modulate their excitability—particularly by glutamatergic input.
Brenton T. Laing, Brenton T. Laing, Peixin Li, Peixin Li, Cameron A. Schmidt, Cameron A. Schmidt, Wyatt Bunner, Wyatt Bunner, Yuan Yuan, Yuan Yuan, Taylor Landry, Taylor Landry, Amber Prete, Joseph M. McClung, Joseph M. McClung, Hu Huang, Hu Huang, Hu Huang   +17 more
doaj   +2 more sources

Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator. [PDF]

Science, 2014
Completing the Set G protein–coupled receptors (GPCRs) are membrane proteins that transduce extracellular signals to activate diverse signaling pathways. Significant insight into GPCR function has come from structures of three of four classes of GPCRs—A,
Wu H, Wang C, Gregory KJ, Han GW, Cho HP, Xia Y, Niswender CM, Katritch V, Meiler J, Cherezov V, Conn PJ, Stevens RC.   +11 more
europepmc   +2 more sources