Results 91 to 100 of about 56,166 (223)

Activation of metabotropic glutamate receptor 1 regulates hippocampal CA1 region excitability in rats with status epilepticus by suppressing the HCN1 channel. [PDF]

Neural Regen Res, 2023
Luo XD, Xiang T, Li SJ, Ma MG, Chen ML, Wu Y.   +5 more
europepmc   +1 more source

Protein Kinase C Family: Structures, Biological Functions, Diseases, and Pharmaceutical Interventions

MedComm, Volume 6, Issue 11, November 2025.
Ligand–receptor binding activates PLC, which hydrolyzes the membrane lipid PIP2, generating the second messenger's IP3 and DAG. IP3 binding to ER receptors causes Ca2⁺ release. Subsequently, PKC are recruited to the membrane, which induces a conformational change in PKC, leading to the full enzymatic activation.
Yongqi Li, Yuhan Jiang, Zhengxi Hu, Shenglan Yang, Longyin Li, Chaohu Xiong, Ya Gao, Weiguang Sun, Yonghui Zhang   +8 more
wiley   +1 more source

Progress toward therapeutic potential for AFQ056 in Fragile X syndrome

Journal of Experimental Pharmacology, 2013
Mary Sourial, Connie Cheng, Laurie C Doering Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada Abstract: Fragile X syndrome (FXS) is the most common form of inherited intellectual disability and the leading ...
Sourial M, Cheng C, Doering LC
doaj  

Crosstalk Between Astrocytes and Inhibitory Neurons During Maturation: Emerging Mechanisms and Functional Implications

Journal of Neurochemistry, Volume 169, Issue 11, November 2025.
In this review, we discuss the development and maturation of inhibitory neurons and astrocytes and how early developmental activity in the brain might promote the interactions between these cell types. Early in development, excitatory neurons are the first to emerge.
Niina Lehti Tauriala, Vered Kellner
wiley   +1 more source

A-Kinase Anchoring Protein 79/150 Scaffolds Transient Receptor Potential A 1 Phosphorylation and Sensitization by Metabotropic Glutamate Receptor Activation

Scientific Reports, 2017
Mechanical pain serves as a base clinical symptom for many of the world’s most debilitating syndromes. Ion channels expressed by peripheral sensory neurons largely contribute to mechanical hypersensitivity.
Allison Doyle Brackley, Ruben Gomez, Kristi A. Guerrero, Armen N. Akopian, Marc J. Glucksman, Junhui Du, Susan M. Carlton, Nathaniel A. Jeske   +7 more
doaj   +1 more source

RNA Granules at the Crossroads of Synaptic Dysfunction and Neurodegeneration

Journal of Neurochemistry, Volume 169, Issue 11, November 2025.
Under physiological conditions, neuronal RNA granules (e.g., transport granules, activity‐dependent granules, processing bodies, and stress granules) cooperate to regulate mRNA transport, storage, and localized translation, thereby sustaining synaptic and neuronal functions.
Rita Nóbrega‐Martins, Beatriz Barros‐Santos, Georgia Papadimitriou, Ioannis Sotiropoulos, Benjamin Wolozin, Joana Margarida Silva   +5 more
wiley   +1 more source

Alternative Splicing Unmasks Dendritic and Axonal Targeting Signals in Metabotropic Glutamate Receptor 1

Journal of Neuroscience, 2002
Precise targeting of neurotransmitter receptors to different neuronal compartments is a fundamental step for the establishment and function of synaptic circuitry.
A. Francesconi, R. Duvoisin
semanticscholar   +1 more source

Cell Type‐Specific mTORC1 Signaling and Translational Control in Synaptic Plasticity and Memory

Journal of Neurochemistry, Volume 169, Issue 11, November 2025.
The formation of long‐term memories depends on de novo protein synthesis, a process tightly regulated by the mechanistic/mammalian target of rapamycin complex 1 (mTORC1) signaling pathway. mTORC1 plays a central role in promoting mRNA translation in the central nervous system.
Ziying Huang, Niaz Mahmood, Shane Wiebe, Arkady Khoutorsky, Jean‐Claude Lacaille, Nahum Sonenberg   +5 more
wiley   +1 more source

Neuroendocrinology meets addiction: Emerging pharmacotherapies on the horizon

Journal of Internal Medicine, Volume 298, Issue 5, Page 392-423, November 2025.
Abstract Alcohol and other substance use disorders (ASUDs) are prevalent and major contributors to global morbidity and mortality. Their impact extends beyond the individual, imposing significant burdens on families, communities, healthcare systems, and society at large.
Anna Loften, Mehdi Farokhnia, Leandro F. Vendruscolo, Lorenzo Leggio   +3 more
wiley   +1 more source

Type-1 metabotropic glutamate receptor signaling in cerebellar Purkinje cells in health and disease [PDF]

, 2017
Masanobu Kano, Takaki Watanabe
openalex   +1 more source