Results 91 to 100 of about 1,029 (201)
How copy number variations shape brain developmental disorders: Unraveling the synaptic puzzle
Psychiatry and Clinical Neurosciences, EarlyView.Neurodevelopmental disorders (NDDs), such as schizophrenia (SCZ), Attention‐deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), learning disabilities, and intellectual disabilities (ID), are highly prevalent. One significant genetic factor associated with NDDs is copy number variations (CNVs), which are structural changes in the ...
Tianqi Wang +3 more
wiley +1 more source
Optimization of photobiomodulation therapy for spinal cord injury: A review
Photochemistry and Photobiology, EarlyView.Photobiomodulation (PBM) therapy in the red and near‐infrared range can significantly modulate the secondary injury response and promote the reparative and regenerative potential of neural tissue after spinal cord injury (SCI). At present, due to the nature of delivery methods, the most effective dose and irradiance at the injury site to optimize ...
Isabella K. M. Drew +3 more
wiley +1 more source
Progress toward therapeutic potential for AFQ056 in Fragile X syndrome
Journal of Experimental Pharmacology, 2013 Mary Sourial, Connie Cheng, Laurie C Doering Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada Abstract: Fragile X syndrome (FXS) is the most common form of inherited intellectual disability and the leading ...
Sourial M, Cheng C, Doering LC
doaj
Cellular Physiology and Biochemistry, 2015 Background: Metabotropic glutamate receptors (mGluRs) are G-protein-coupled receptors that mediate neuronal excitability and synaptic plasticity in the central nervous system, and emerging evidence suggests a role of mGluRs in the biology of cancer ...
Chi Zhang +8 more
doaj +1 more source
Astrocytes: Orchestrators of brain gas exchange and oxygen homeostasis
The Journal of Physiology, EarlyView.Abstract figure legend Oxygen and carbon dioxide enter the body via breathing; in the brain astrocytes play a key role balancing oxygen delivery with carbon dioxide removal. Abstract If we consider neurons like muscles during exercise, the demand for oxygen (O2) and carbon dioxide (CO2) elimination is constantly changing.
Isabel N. Christie
wiley +1 more source
Potential health benefits of cold‐water immersion: the central role of PGC‐1α
The Journal of Physiology, EarlyView.Abstract figure legend Cold‐water immersion (CWI) elicits autonomic, somato‐motoric (shivering thermogenesis), endocrine and metabolic, sensory transduction, and local biophysical effects that may converge on the transcriptional co‐activator PGC‐1α (centre).
Erich Hohenauer +2 more
wiley +1 more source
Scientific Reports, 2017 Mechanical pain serves as a base clinical symptom for many of the world’s most debilitating syndromes. Ion channels expressed by peripheral sensory neurons largely contribute to mechanical hypersensitivity.
Allison Doyle Brackley +7 more
doaj +1 more source
Type-1 metabotropic glutamate receptor signaling in cerebellar Purkinje cells in health and disease [PDF]
, 2017 Masanobu Kano, Takaki Watanabe
openalex +1 more source
Bifenthrin Under Scrutiny: Revisiting Toxicological Evidence Amid Regulatory Gaps
Journal of Applied Toxicology, Volume 46, Issue 1, Page 61-77, January 2026.ABSTRACT Despite growing health concerns, bifenthrin (BF) remains widely used for controlling agricultural and residential pests. However, different perspectives on its toxicological profile and regulatory framework warrant a revisit and update on BF regulation towards a robust risk‐safety assessment.
Caroline V. L. Moreira +10 more
wiley +1 more source
British Journal of Pharmacology, Volume 183, Issue 2, Page 296-312, January 2026.Background and Purpose Neuroinflammation is increasingly recognised to contribute to drug‐resistant epilepsy. Activation of ATP‐gated P2X7 receptors has emerged as an important upstream mechanism, and increased P2X7 receptor expression is present in the seizure focus in rodent models and patients. Pharmacological antagonists of P2X7 receptors attenuate
Jaideep Kesavan +6 more
wiley +1 more source