Results 101 to 110 of about 1,029 (201)

Expanding the Immunologic and Neuronal Landscape of IgE‐Mediated Anaphylaxis

Immunological Reviews, Volume 337, Issue 1, January 2026.
ABSTRACT Anaphylaxis is a life‐threatening immunoglobulin E (IgE)‐mediated type I hypersensitivity reaction with rising prevalence and burden. It involves mast cell degranulation upon cross‐linking of antigen on mast cell‐bound IgE. Mechanisms of IgE‐mediated anaphylaxis remain incompletely understood, particularly the induction of systemic symptoms ...
Ruchi Biswas, Jamie Moore Fried, Maria A. Curotto de Lafaille   +2 more
wiley   +1 more source

Characterizing Spatial Associations Between GluCEST MRI and Neurotransmitter Receptor Density in the Human Cortex

Human Brain Mapping, Volume 46, Issue 18, 15 December 2025.
We leveraged in vivo 7T GluCEST MRI and normative PET receptor maps to examine the spatial covariation between cortical glutamate levels and receptor expression. GluCEST signal showed positive spatial associations with NMDA and GABAA, but not mGluR5. These findings enhance our understanding of GluCEST and glutamate‐receptor dynamics across the cortex ...
Maggie K. Pecsok, Golia Shafiei, Ally Atkins, Monica E. Calkins, Ruben C. Gur, Ravi Prakash Reddy Nanga, Ravinder Reddy, Melanie A. Matyi, Jacquelyn Stifelman, Heather Robinson, Erica B. Baller, Russell T. Shinohara, Kosha Ruparel, Kristin A. Linn, Daniel H. Wolf, Theodore D. Satterthwaite, Corey T. McMillan, David Roalf   +17 more
wiley   +1 more source

Infrared Neural Stimulation Elicits Distinct Molecular Pathways in Astrocytes Based on Laser Pulse Parameters

Advanced Biology, Volume 9, Issue 12, December 2025.
Infrared (IR) light evokes distinct calcium and water transport responses in astrocytes, depending on stimulation duration and protocol. This study uses widefield imaging and pharmacology to reveal differential engagement of astroglial signaling pathways.
Wilson R. Adams, Ana I Borrachero‐Conejo, Pratheepa Kumari Rasiah, Emanuela Saracino, Roberto Zamboni, Eric Duco Jansen, Valentina Benfenati, Anita Mahadevan‐Jansen   +7 more
wiley   +1 more source

Direct and indirect pathways for heterosynaptic interaction underlying developmental synapse elimination in the mouse cerebellum

Communications Biology
Developmental synapse elimination is crucial for shaping mature neural circuits. In the neonatal mouse cerebellum, Purkinje cells (PCs) receive excitatory synaptic inputs from multiple climbing fibers (CFs) and synapses from all but one CF are eliminated
Hisako Nakayama, Taisuke Miyazaki, Manabu Abe, Maya Yamazaki, Yoshinobu Kawamura, Myeongjeong Choo, Kohtarou Konno, Shinya Kawata, Naofumi Uesaka, Kouichi Hashimoto, Mariko Miyata, Kenji Sakimura, Masahiko Watanabe, Masanobu Kano   +13 more
doaj   +1 more source

Group III metabotropic glutamate receptors and transient receptor potential vanilloid 1 co-localize and interact on nociceptors [PDF]

, 2012
R. Govea, Siyuan Zhou, Susan M. Carlton
openalex   +1 more source

Activation of GABAB receptors attenuate Alzheimer's disease related pathophysiology in a preclinical APP/PS1 transgenic model

Alzheimer's &Dementia, Volume 21, Issue S1, December 2025.
Abstract Background Alongside the major hallmarks of Alzheimer's disease (AD) – amyloid beta (Aβ) plaque, tau tangles, and neurodegeneration – hippocampal synapse loss also presents as a pathological phenotype in this disorder. While there is extensive research linking synapse loss to hyperexcitability and glutamate excitotoxicity, there is a gap in ...
Colin J McArdle, Abigail Caudill, Kimberly F Raab‐Graham   +2 more
wiley   +1 more source

Metabotropic glutamate receptor 1 recycles to the cell surface in protein phosphatase 2A‐dependent manner in non‐neuronal and neuronal cell lines [PDF]

, 2014
Saurabh Pandey, Prabhat Kumar Mahato, Samarjit Bhattacharyya   +2 more
openalex   +1 more source

Alzheimer's disease is associated with changes in the metabotropic glutamate mGlu3 receptor expression but not with SNPs in the GRM3 gene

Alzheimer's &Dementia, Volume 21, Issue S2, December 2025.
Abstract Background Our group has demonstrated that the subtype 3 metabotropic glutamate receptor (mGlu3R) expressed in astrocytes exerts neuroprotective functions and promotes both non‐amyloidogenic cleavage of APP and Aβ clearance. In turn, we showed that mGlu3R levels progressively decreased with age in the hippocampus of PDAPP‐J20 murine AD model ...
Eugenia Olivera, Pilar Garaventa, Albany Saez, Ana Clara Romero, Daniela Zelaya, Mercedes Bigi, Carla Caruso, Juan Beauquis, Flavia Saravia, Mercedes Lasaga, Daniela Durand   +10 more
wiley   +1 more source

Buried Treasure? Overlooked and Newly Discovered Evolutionary Contributions to Human Brain Diseases

Annals of Neurology, Volume 98, Issue 6, Page 1178-1195, December 2025.
[Color figure can be viewed at www.annalsofneurology.org] Recapitulative schema of different exploratory levels of the evolutionary impact on human neurological diseases. Clinical neuroscience focuses on the mechanisms of brain function, but this approach falls short of insights into how the central nervous system (CNS) evolved, both in health and ...
Nico J. Diederich, Martin Brüne, John S. Allen, Nicole Bender, Emiliano Bruner, Jean‐Pierre Changeux, Corrado Cali, Olga Dolgova, Anne Grünewald, Geneviève Konopka, Peng Jin, Roger Lemon, Gilberto Levy, Pierre Magistretti, Markus J. Rantala, Kathleen S. Rockland, Roger Sullivan, Annie Swanepoel, Toshiki Uchihara, Katrin Amunts, Christopher G. Goetz   +20 more
wiley   +1 more source

Lifelong Impact of Prenatal Stress: Exacerbated Memory Impairments and Gene Expression Changes Under Adult Chronic Stress

Brain and Behavior, Volume 15, Issue 12, December 2025.
ABSTRACT Introduction Chronic stress can have significant impacts on both physical and mental health, including affecting learning and memory processes. Research has shown that exposure to stress during prenatal and neonatal stages can have long‐lasting effects on individuals. The objective of this study is to investigate how prenatal stress influences
Manijeh Dogani, Nayere Askari, Mohammad‐Reza Vaez‐Mahdavi   +2 more
wiley   +1 more source