Results 101 to 110 of about 52,371 (282)

Exploring the pathophysiology underlying clozapine‐induced enhancement of glutamatergic transmission through L‐glutamate and D‐serine release associated with pannexin1 hemichannels

British Journal of Pharmacology, EarlyView.
Abstract Background and purpose Clozapine, an approved antipsychotic for treatment‐resistant schizophrenia (TRS), enhances glutamatergic transmission by increasing exocytosis and non‐exocytosis glutamate release; however, its full action remained to be clarified.
Motohiro Okada, Ruri Okubo, Eishi Motomura   +2 more
wiley   +1 more source

Blunted Cystine–Glutamate Antiporter Function in the Nucleus Accumbens Promotes Cocaine-induced Drug Seeking [PDF]

, 2008
Repeated cocaine alters glutamate neurotransmission, in part, by reducing cystine–glutamate exchange via system xc−, which maintains glutamate levels and receptor stimulation in the extrasynaptic compartment.
Abdulhameed, Omer, Baker, David A., Grier, Mark D., Kau, Kristen S., Madayag, Aric, Mantsch, John R.   +5 more
core   +1 more source

Genetic inactivation of mGlu5 receptor improves motor coordination in the Grm1crv4 mouse model of SCAR13 ataxia

Neurobiology of Disease, 2018
Deleterious mutations in the glutamate receptor metabotropic 1 gene (GRM1) cause a recessive form of cerebellar ataxia, SCAR13. GRM1 and GRM5 code for the metabotropic glutamate type 1 (mGlu1) and type 5 (mGlu5) receptors, respectively.
Simone Bossi, Ilaria Musante, Tommaso Bonfiglio, Tiziana Bonifacino, Laura Emionite, Maria Cerminara, Chiara Cervetto, Manuela Marcoli, Giambattista Bonanno, Roberto Ravazzolo, Anna Pittaluga, Aldamaria Puliti   +11 more
doaj  

Interplay between metabotropic glutamate type 4 and adenosine type 1 receptors modulate synaptic transmission in the cerebellar cortex

Frontiers in Pharmacology
The synapses between parallel fibers and Purkinje cells play a pivotal role in cerebellar function. They are intricately governed by a variety of presynaptic receptors, notably by type 4 metabotropic glutamate (mGlu4) receptors and type 1 adenosine (A1 ...
Simon Bossi, Hervé Daniel, Heather McLean   +2 more
doaj   +1 more source

Performance of cryptogenic new onset refractory status epilepticus score in a Brazilian cohort after testing for antineuronal antibodies with tissue‐based and cell‐based assays

Epilepsia, EarlyView.
Abstract Objective This study was undertaken to describe a case series of Brazilian new onset refractory status epilepticus (NORSE) patients and evaluate the sensitivity and specificity of a clinical score to predict cryptogenic etiology (c‐NORSE score) after autoimmune encephalitis (AE) testing.
João Henrique Fregadolli Ferreira, Anna Maria Gomes, Ana Carolina Zetehaku, Taissa Ferrari Marinho, Fabio Fieni Toso, Caio César Diniz Disserol, Mariana Braatz Krueger, Mara Lúcia Schmitz Ferreira Santos, Aline Freire Borges Juliano, Tércio Luz Barbosa, Letícia Januzi de Almeida Rocha, Fernando Tenório Gameleira, Renata Barbosa Paolilo, Vanessa Daccach, João Pedro Izidoro Gomes, Katia Lin, Adaucto Wanderley da Nóbrega Jr., Emily Lima Marmentini, Eduardo Ferracioli Fusão, Anderson de Cuffa, Georgia Lelis Aranha Tavares, Ronaldo Maciel Dias, Sabrina Stephanie Lana Diniz, Fábio Siquineli, Pedro Braga‐Neto, Paulo Ribeiro Nobrega, Lorena Pitombeira Sanders, Fernanda Martins Maia Carvalho, Renata Brasileiro Reis Pereira, Eduardo Sousa de Melo, Adélia Maria de Miranda Henriques‐Souza, Clecio de Oliveira Godeiro Jr., Omar Gurrola Arambula, Filipe Nolasco de Souza e Silva, Karla Oliveira Couto, Dayane Danieli, Katia Werneck Seitz, Alessandra Dellavance, Verena Endmayr, Romana Höftberger, Luis Eduardo Coelho Andrade, Luis Otavio Caboclo, Livia Almeida Dutra   +42 more
wiley   +1 more source

Participation of the Cholinergic System in Ameliorating Effect of Vasopressin Fragment by Group I Metabotropic Glutamate–Receptor Blockade

Journal of Pharmacological Sciences, 2008
The effect of [pGlu4,Cyt6,Arg8]-vasopressin fragment 4-9 (AVP4-9) on group I metabotropic glutamate (mGlu1) receptor antagonist–induced memory deficits was studied using 8-arm radial maze performance with 4 arms baited.
Tadatsugu Tarumi, Azusa Mikami, Kenichi Shimada, Chiaki Kamei   +3 more
doaj  

Metabotropic Glutamate Receptor Type 1 Autoantibody–Associated Cerebellitis [PDF]

Archives of Neurology, 2010
To report the third case of subacute cerebellar ataxia associated with metabotropic glutamate receptor type 1 autoantibodies (mGluR1-Abs), an uncommon syndrome known to be part of the group of paraneoplastic cerebellar degeneration syndromes linked to antineuronal antibodies and previously reported in only 2 other patients with long-term remission of ...
Christian Confavreux, Christel Renoux, Sandra Vukusic, Francesc Graus, Peter A. E. Sillevis Smitt, Jérôme Honnorat, Véronique Rogemond, Gaëlle Cavillon, Géraldine Androdias, Romain Marignier, Florian Chenevier   +10 more
openaire   +4 more sources

Clioquinol as a new therapy in epilepsy: From preclinical evidence to a proof‐of‐concept clinical study

Epilepsia, EarlyView.
Abstract Objective Drug‐resistant epilepsy (DRE) affects >25 million people worldwide and is often associated with neuroinflammation. Increasing evidence links deficiency or malfunctioning of the enzyme phosphoglycerate dehydrogenase (PHGDH), which converts 3‐phosphoglycerate to generate serine and the neurotransmitter glycine, with (drug‐resistant ...
Karin Thevissen, Annelii Ny, Daniëlle Copmans, Jana Tits, Kenichi Kamata, Eva Gielis, Kevin Longin, Jo Sourbron, Peravina Thergarajan, Tracie Huey‐Lin Tan, Idrish Ali, Nigel C. Jones, Terence J. O'Brien, Mastura Monif, Bridgette D. Semple, Christine Germeys, Benedetta Frizzi, Virginia Minniti, Sebastian Perrone, Carole L. Linster, Ilaria Elia, Ludo Van Den Bosch, Bruno P. A. Cammue, Arnout Voet, Lieven Lagae, Peter de Witte   +25 more
wiley   +1 more source

Long-term activation of group I metabotropic glutamate receptors increases functional TRPV1-expressing neurons in mouse dorsal root ganglia

Frontiers in Cellular Neuroscience, 2016
Damaged tissues release glutamate and other chemical mediators for several hours. These chemical mediators contribute to modulation of pruritus and pain.
Takayoshi eMasuoka, Makiko eKudo, Junko eYoshida, Takaharu eIshibashi, Takaharu eIshibashi, Ikunobu eMuramatsu, Nobuo eKato, Noriko eImaizumi, Matomo eNishio   +8 more
doaj   +1 more source

Loss of retinoid X receptor gamma subunit impairs group 1 mGluR mediated electrophysiological responses and group 1 mGluR dependent behaviors

Scientific Reports, 2021
Retinoid X receptors are members of the nuclear receptor family that regulate gene expression in response to retinoic acid and related ligands. Group 1 metabotropic glutamate receptors are G-protein coupled transmembrane receptors that activate ...
Chirag Upreti, Caitlin M. Woodruff, Xiao-Lei Zhang, Michael J. Yim, Zhen-yu Zhou, Andrew M. Pagano, Dina S. Rehanian, Deqi Yin, Eric R. Kandel, Patric K. Stanton, Russell E. Nicholls   +10 more
doaj   +1 more source