Results 101 to 110 of about 56,166 (223)

Adaptations to hypoxia in the vertebrate retina

The Journal of Physiology, Volume 603, Issue 21, Page 6517-6531, November 1, 2025.
Abstract figure legend Most animals, including mammals, are susceptible to the damaging effects of hypoxia or ischaemia, where the result is neuronal cell death in the brain. By contrast, some neurons of the mammalian retina are less sensitive to hypoxia. In both brain and retina, neurons may survive if first preconditioned with ischaemia.
Michael G. Jonz
wiley   +1 more source

The mysterious middlemen making your vision pop: understanding the function of amacrine cells

The Journal of Physiology, Volume 603, Issue 21, Page 6473-6502, November 1, 2025.
Abstract figure legend This review aims to illustrate the diversity and function of amacrine cells in the retina. The diversity of amacrine cell subtypes is depicted based on morphology, stratification and neurotransmitter expression, along with their synaptic connectivity with bipolar and ganglion cells, emphasizing inhibitory and modulatory roles ...
Victor Calbiague‐Garcia, Deborah Varro, Thomas Buffet, Olivier Marre   +3 more
wiley   +1 more source

Direct and indirect pathways for heterosynaptic interaction underlying developmental synapse elimination in the mouse cerebellum

Communications Biology
Developmental synapse elimination is crucial for shaping mature neural circuits. In the neonatal mouse cerebellum, Purkinje cells (PCs) receive excitatory synaptic inputs from multiple climbing fibers (CFs) and synapses from all but one CF are eliminated
Hisako Nakayama, Taisuke Miyazaki, Manabu Abe, Maya Yamazaki, Yoshinobu Kawamura, Myeongjeong Choo, Kohtarou Konno, Shinya Kawata, Naofumi Uesaka, Kouichi Hashimoto, Mariko Miyata, Kenji Sakimura, Masahiko Watanabe, Masanobu Kano   +13 more
doaj   +1 more source

Group 1 metabotropic glutamate receptor function and its regulation of learning and memory in the aging brain

Frontiers in Pharmacology, 2012
Normal aging is generally characterized by a slow decline of cognitive abilities albeit with marked individual differences. Several animal models have been studied to explore the molecular and cellular mechanisms underlying this phenomenon.
Caroline eMénard, Rémi eQuirion
doaj   +1 more source

Group III metabotropic glutamate receptors and transient receptor potential vanilloid 1 co-localize and interact on nociceptors [PDF]

, 2012
R. Govea, Siyuan Zhou, Susan M. Carlton
openalex   +1 more source

TRPC6 effects on albumin permeation, nephrin shedding, and apoptosis in podocytes: Role of calcineurin and metalloproteases

Physiological Reports, Volume 13, Issue 21, November 2025.
Certain ligands of pattern recognition receptors can induce a rapid increase in albumin permeability across a podocyte monolayer that can be seen in 1 h, but activation of TRPC6 for up to 24 h does not mimick this process. However, continuous TRPC6 activation for 24 h results in nephrin ectodomain shedding that calcineurin activation and ...
Eun Young Kim, Stuart E. Dryer
wiley   +1 more source

Modulation of the Neurovascular Unit by the Locus Coeruleus–Norepinephrine System: From Physiological Mechanisms to Therapeutic Applications

The FASEB Journal, Volume 39, Issue 20, 31 October 2025.
The locus coeruleus (LC)–norepinephrine (NE) system significantly influences the structure and function of the neurovascular unit (NVU). The activation degree and firing patterns of LC–NE neurons, as well as the release amount and action sites of NE, profoundly impact the neurons, glial cells, and cerebrovascular components of the NVU.
Zixin Pan, Zhaoxing Jia, Tianxiang Jiang, Qian Cai, Zhong Di, Lin Gan, Congcong Ma, Xianming Lin   +7 more
wiley   +1 more source

Inhibitory effects of high extracellular l-glutamate concentrations on skeletal myogenesis

Scientific Reports
l-glutamate (Glu) is accumulated abundantly in skeletal muscle cells and plays a central role in energy production, amino acid metabolism, and protein synthesis.
Himiko Ban, Koji Nobe, Soushi Kobayashi
doaj   +1 more source

Group 1 Metabotropic Glutamate Receptors in Neurological and Psychiatric Diseases: Mechanisms and Prospective

, 2021
Li‐Da Su, Na Wang, Junhai Han, Ying Shen   +3 more
openalex   +1 more source

¹³¹I-IITM and ²¹¹At-AITM: Two Novel Small-Molecule Radiopharmaceuticals Targeting Oncoprotein Metabotropic Glutamate Receptor 1. [PDF]

J Nucl Med, 2020
Xie L, Hanyu M, Fujinaga M, Zhang Y, Hu K, Minegishi K, Jiang C, Kurosawa F, Morokoshi Y, Li HK, Hasegawa S, Nagatsu K, Zhang MR.   +12 more
europepmc   +1 more source