Results 101 to 110 of about 582,384 (267)

Recent Developments in the Optical Control of Adrenergic Signaling

Medicinal Research Reviews, EarlyView.
ABSTRACT Adrenoceptors (ARs) play a vital role in various physiological processes and are key therapeutic targets. The advent of optical control techniques, including optogenetics and photopharmacology, offers the potential to modulate AR signaling with precise temporal and spatial resolution. In this review, we summarize the latest advancements in the
Shuang Shi, Yangzhi Cao, Maikel Wijtmans, Henry F. Vischer, Rob Leurs   +4 more
wiley   +1 more source

Participation of the Cholinergic System in Ameliorating Effect of Vasopressin Fragment by Group I Metabotropic Glutamate–Receptor Blockade

Journal of Pharmacological Sciences, 2008
The effect of [pGlu4,Cyt6,Arg8]-vasopressin fragment 4-9 (AVP4-9) on group I metabotropic glutamate (mGlu1) receptor antagonist–induced memory deficits was studied using 8-arm radial maze performance with 4 arms baited.
Tadatsugu Tarumi, Azusa Mikami, Kenichi Shimada, Chiaki Kamei   +3 more
doaj  

Loss of retinoid X receptor gamma subunit impairs group 1 mGluR mediated electrophysiological responses and group 1 mGluR dependent behaviors

Scientific Reports, 2021
Retinoid X receptors are members of the nuclear receptor family that regulate gene expression in response to retinoic acid and related ligands. Group 1 metabotropic glutamate receptors are G-protein coupled transmembrane receptors that activate ...
Chirag Upreti, Caitlin M. Woodruff, Xiao-Lei Zhang, Michael J. Yim, Zhen-yu Zhou, Andrew M. Pagano, Dina S. Rehanian, Deqi Yin, Eric R. Kandel, Patric K. Stanton, Russell E. Nicholls   +10 more
doaj   +1 more source

Long-term activation of group I metabotropic glutamate receptors increases functional TRPV1-expressing neurons in mouse dorsal root ganglia

Frontiers in Cellular Neuroscience, 2016
Damaged tissues release glutamate and other chemical mediators for several hours. These chemical mediators contribute to modulation of pruritus and pain.
Takayoshi eMasuoka, Makiko eKudo, Junko eYoshida, Takaharu eIshibashi, Takaharu eIshibashi, Ikunobu eMuramatsu, Nobuo eKato, Noriko eImaizumi, Matomo eNishio   +8 more
doaj   +1 more source

Robust gamma oscillations in networks of inhibitory Hippocampal interneurons [PDF]

arXiv, 1999
Recent experiments suggest that inhibitory networks of interneurons can synchronize the neuronal discharge in in vitro hippocampal slices. Subsequent theoretical work has shown that strong synchronization by mutual inhibition is only moderately robust against neuronal heterogeneities in the current drive, provided by activation of metabotropic ...
arxiv  

A single psychotomimetic dose of ketamine decreases thalamocortical spindles and delta oscillations in the sedated rat [PDF]

arXiv, 2020
Background: In patients with psychotic disorders, sleep spindles are reduced, supporting the hypothesis that the thalamus and glutamate receptors play a crucial etio-pathophysiological role, whose underlying mechanisms remain unknown. We hypothesized that a reduced function of NMDA receptors is involved in the spindle deficit observed in schizophrenia.
arxiv  

Extracellular Ca2+ and Glutamate Modulating the Function of Metabotropic Glutamate Receptor 1 Alpha (mGluR1α) [PDF]

Biophysical Journal, 2010
Metabotropic Glutamate Receptor subtype 1 alpha (mGluR1α) mediates the accumulation of IP3 and DAG, release of intracellular Ca2+ from ER, and activation of PKC and PKA, by interacting with extracellular glutamate and Ca2+. While more than 12 X-ray Structures of different forms of the extracellular domain (ECD) has been determined, the detailed binding
openaire   +2 more sources

Metabotropic Glutamate Receptor Type 1 Autoantibody–Associated Cerebellitis [PDF]

Archives of Neurology, 2010
To report the third case of subacute cerebellar ataxia associated with metabotropic glutamate receptor type 1 autoantibodies (mGluR1-Abs), an uncommon syndrome known to be part of the group of paraneoplastic cerebellar degeneration syndromes linked to antineuronal antibodies and previously reported in only 2 other patients with long-term remission of ...
Christian Confavreux, Christel Renoux, Sandra Vukusic, Francesc Graus, Peter A. E. Sillevis Smitt, Jérôme Honnorat, Véronique Rogemond, Gaëlle Cavillon, Géraldine Androdias, Romain Marignier, Florian Chenevier   +10 more
openaire   +4 more sources

Multiple Routes for Glutamate Receptor Trafficking: Surface Diffusion and Membrane Traffic Cooperate to Bring Receptors to Synapses [PDF]

Science's STKE (electronic resource) : signal transduction knowledge environment 327 (21/03/2006) 13, 2007
Trafficking of glutamate receptors into and out of synapses is critically involved in the plasticity of excitatory synaptic transmission. Endocytosis and exocytosis of receptors have initially been thought to account alone for this trafficking. However, membrane proteins also traffic through surface lateral diffusion in the plasma membrane. We describe
arxiv  

Nicotinic α7 acetylcholine receptor-mediated currents are not modulated by the tryptophan metabolite kynurenic acid in adult hippocampal interneurons [PDF]

, 2012
The tryptophan metabolite, kynurenic acid (KYNA), is classically known to be an antagonist of ionotropic glutamate receptors. Within the last decade several reports have been published suggesting that KYNA also blocks nicotinic acetylcholine receptors (nAChRs) containing the \alpha7 subunit (\alpha7*).
arxiv   +1 more source