Results 111 to 120 of about 582,384 (267)
Microscopy and spectroscopy approaches to study GPCR structure and function
British Journal of Pharmacology, EarlyView.Abstract The GPCR signalling cascade is a key pathway responsible for the signal transduction of a multitude of physical and chemical stimuli, including light, odorants, neurotransmitters and hormones. Understanding the structural and functional properties of the GPCR cascade requires direct observation of signalling processes in high spatial and ...
Tomáš Fessl +2 more
wiley +1 more source
eLife, 2018 Dopamine neurons have different synaptic actions in the ventral and dorsal striatum (dStr), but whether this heterogeneity extends to dStr subregions has not been addressed.
Nao Chuhma +12 more
doaj +1 more source
Carbon Paste Electrode Modified Poly-Glutamic Acid (PGA) with Molecularly Imprinted for Detection of Rhodamine B [PDF]
IOP Material Science and Engineering June 2021, 2020 Rhodamine B is a synthetic dye used for coloring textiles, paper and ceramics. In addition, Rhodamine B is also often used for coloring ingredients in food ingredients such as crackers, syrups, candy, cakes, and is often used for coloring lipsticks. The accumulation of Rhodamine B in the body can cause liver, kidney and lymph damage.
arxiv
The dark sides of the GPCR tree ‐ research progress on understudied GPCRs
British Journal of Pharmacology, EarlyView.Abstract A large portion of the human GPCRome is still in the dark and understudied, consisting even of entire subfamilies of GPCRs such as odorant receptors, class A and C orphans, adhesion GPCRs, Frizzleds and taste receptors. However, it is undeniable that these GPCRs bring an untapped therapeutic potential that should be explored further.
Magdalena M. Scharf +10 more
wiley +1 more source
Implication of neuronal Ca2+-sensor protein VILIP-1 in the glutamate hypothesis of schizophrenia
Neurobiology of Disease, 2008 Post mortem studies in the hippocampus of schizophrenia patients revealed increased expression of neuronal Ca2+-sensor VILIP-1 (visinin-like protein) and enhanced co-localization with α4β2 nAChR in interneurons. To study the pathological role of VILIP-1,
Paul Gierke +6 more
doaj
G protein‐coupled receptor‐mediated autophagy in health and disease
British Journal of Pharmacology, EarlyView.G protein‐coupled receptors (GPCRs) constitute the largest and most diverse superfamily of mammalian transmembrane proteins. These receptors are involved in a wide range of physiological functions and are targets for more than a third of available drugs in the market. Autophagy is a cellular process involved in degrading damaged proteins and organelles
Devrim Öz‐Arslan +2 more
wiley +1 more source
Cellular Physiology and Biochemistry, 2015 Background: Metabotropic glutamate receptors (mGluRs) are G-protein-coupled receptors that mediate neuronal excitability and synaptic plasticity in the central nervous system, and emerging evidence suggests a role of mGluRs in the biology of cancer ...
Chi Zhang +8 more
doaj +1 more source
ERNEST COST action overview on the (patho)physiology of GPCRs and orphan GPCRs in the nervous system
British Journal of Pharmacology, EarlyView.G protein‐coupled receptors (GPCRs) are a large family of cell surface receptors that play a critical role in nervous system function by transmitting signals between cells and their environment. They are involved in many, if not all, nervous system processes, and their dysfunction has been linked to various neurological disorders representing important
Necla Birgül Iyison +15 more
wiley +1 more source
Activation of metabotropic glutamate receptor 1 regulates hippocampal CA1 region excitability in rats with status epilepticus by suppressing the HCN1 channel. [PDF]
Neural Regen Res, 2023 Luo XD +5 more
europepmc +1 more source
Allosterism in the adenosine A2A and cannabinoid CB2 heteromer
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Allosterism is a regulatory mechanism for GPCRs that can be attained by ligand‐binding or protein–protein interactions with another GPCR. We have studied the influence of the dimer interface on the allosteric properties of the A2A receptor and CB2 receptor heteromer.
Claudia Llinas del Torrent +7 more
wiley +1 more source