Results 111 to 120 of about 1,029 (201)

Functional Brain Connectivity Patterns of Headache–Mental Disorder Comorbidity in Patients With Migraine

open access: yesCNS Neuroscience &Therapeutics, Volume 31, Issue 12, December 2025.
This study identified the functional brain connectivity patterns that were correlated with headache and mental conditions in migraineurs and then detected that those features had potential to discriminate patients from healthy controls, stratify patients into subgroups, and predict treatment outcomes.
Tao Yin   +7 more
wiley   +1 more source

Seizures beget more than seizures: Understanding the cellular, structural, individual and societal impact of seizures in epilepsy

open access: yesEpilepsia Open, Volume 10, Issue 6, Page 1762-1773, December 2025.
Abstract Epilepsy is primarily defined by the repetitive occurrence of seizures, but the full impact of seizures extends beyond these episodic events. Seizures themselves cause changes at the cellular, network, and systemic levels in individual patients with epilepsy and may contribute to the progressive nature of the disease in some patients. Seizures
Matthew C. Walker   +3 more
wiley   +1 more source

Neurotransmitters and Immunity: Molecular Mechanisms, Biological Functions, Diseases, and Potential Therapeutic Targets

open access: yesMedComm, Volume 6, Issue 12, December 2025.
Role of neurotransmitters in multiple pathological processes. Various neurotransmitters, including ACh, EPI, NE, 5‐HT, histamine, DA, glutamate, GABA, and neuropeptides participate in regulating key pathological events, including tumor proliferation, tumor migration, remodeling of the immune microenvironment, and the development of NDDs and ...
Gege Li   +13 more
wiley   +1 more source

Inhibitory effects of high extracellular l-glutamate concentrations on skeletal myogenesis

open access: yesScientific Reports
l-glutamate (Glu) is accumulated abundantly in skeletal muscle cells and plays a central role in energy production, amino acid metabolism, and protein synthesis.
Himiko Ban, Koji Nobe, Soushi Kobayashi
doaj   +1 more source

Oligodendrocyte Precursor Cells in Demyelination Repair: Mechanisms, Crosstalk, and Therapeutic Frontiers

open access: yesMedicine Bulletin, Volume 1, Issue 2, Page 104-120, December 2025.
ABSTRACT In multiple sclerosis (MS), demyelination is often accompanied by severe motor and cognitive disability. Remyelination is the process of regenerating new myelin sheath on impaired axons, which is typically carried out by oligodendrocyte precursor cells (OPCs).
Zixin Gao   +6 more
wiley   +1 more source

Methcathinone Neurotoxicity in the Rat Prefrontal Cortex by Integrated Synaptic Changes and Transcriptome Analysis

open access: yesAddiction Biology, Volume 30, Issue 12, December 2025.
Integrating behavioural, ultrastructural and transcriptomic analyses, this study reveals that subchronic methcathinone exposure damages prefrontal synaptic architecture and alters neuroplasticity‐related gene networks, providing mechanistic insight into its neurotoxic and cognition‐impairing effects.
Rukui Zhou   +6 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Introduction and Other Protein Targets

open access: yesBritish Journal of Pharmacology, Volume 182, Issue S1, Page S1-S23, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander   +51 more
wiley   +1 more source

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