Activation of metabotropic glutamate receptor 1 regulates hippocampal CA1 region excitability in rats with status epilepticus by suppressing the HCN1 channel. [PDF]
Neural Regen Res, 2023 Luo XD +5 more
europepmc +1 more source
Fundamental &Clinical Pharmacology, Volume 39, Issue 4, August 2025.ABSTRACT In the 1950s–60s, serotonergic psychedelic drugs were studied as potential adjuvants to psychotherapy to treat addiction and alcoholism. However, starting in the 70s, preclinical and clinical studies on psychedelics stopped for decades because legislation controlled its recreational use, citing their hallucinogenic and psychotomimetic effects,
Makiath Adebo +9 more
wiley +1 more source
Morphological plasticity of astroglia: Understanding synaptic microenvironment [PDF]
, 2015 Memory formation in the brain is thought to rely on the remodeling of synaptic connections which eventually results in neural network rewiring. This remodeling is likely to involve ultrathin astroglial protrusions which often occur in the immediate ...
Heller, JP, Rusakov, DA
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Amygdala Metabotropic Glutamate Receptor 1 Influences Synaptic Transmission to Participate in Fentanyl-Induced Hyperalgesia in Rats. [PDF]
Cell Mol Neurobiol, 2023 Bai T +9 more
europepmc +1 more source
Advanced Healthcare Materials, Volume 14, Issue 17, July 4, 2025.A wireless cortical surface implant employing graphene electrode arrays diagnoses and alleviates Parkinson's disease symptoms in freely moving animals. The device continuously monitors cortical activity and delivers targeted stimulation, restoring beta–gamma and delta oscillations.
Hongseong Shin +15 more
wiley +1 more source
Immunostaining for Homer reveals the majority of excitatory synapses in laminae I-III of the mouse spinal dorsal horn [PDF]
, 2016 The spinal dorsal horn processes somatosensory information before conveying it to the brain. The neuronal organization of the dorsal horn is still poorly understood, although recent studies have defined several distinct populations among the interneurons,
Abraira, Victoria E. +5 more
core +2 more sources
Progress toward therapeutic potential for AFQ056 in Fragile X syndrome
Journal of Experimental Pharmacology, 2013 Mary Sourial, Connie Cheng, Laurie C Doering Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada Abstract: Fragile X syndrome (FXS) is the most common form of inherited intellectual disability and the leading ...
Sourial M, Cheng C, Doering LC
doaj
The Effect of Acylcarnitines on Cognitive Function: A Two‐Sample Mendelian Randomization Study
Brain and Behavior, Volume 15, Issue 7, July 2025.This study is the first to employed TSMR to investigate the causal relationship between 20 acylcarnitines and neurocognitive outcomes. The findings indicate that lower genetically predicted levels of acetyl‐L‐carnitine and butyrylcarnitine are associated with diminished cognitive performance, underscoring their potential clinical implications in the ...
Sisi Luan +4 more
wiley +1 more source
European Journal of Pain, Volume 29, Issue 6, July 2025.ABSTRACT Background Glutamate, the primary neurotransmitter released by nociceptors, is predominantly synthesised by the enzyme Glutaminase 1 (GLS1). The involvement of GLS1 in pain pathways is well supported, as Gls1 heterozygous mice exhibit altered nociception and GLS1 levels increase in the dorsal root ganglia (DRG) under chronic peripheral ...
Anabel Martínez‐Padilla +4 more
wiley +1 more source
Drug-Induced Plasticity Contributing to Heightened Relapse Susceptibility: Neurochemical Changes and Augmented Reinstatement in High-Intake Rats [PDF]
, 2010 A key in understanding the neurobiology of addiction and developing effective pharmacotherapies is revealing drug-induced plasticity that results in heightened relapse susceptibility.
Baker, David A. +5 more
core +1 more source