Results 161 to 170 of about 1,029 (201)
Regulation of cyclin-dependent kinase 5 and casein kinase 1 by metabotropic glutamate receptors
, 2001 Feng Liu +8 more
openalex +1 more source
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Metabotropic Glutamate 1 Receptor: Current Concepts and Perspectives
Pharmacological Reviews, 2008Almost 25 years after the first report that glutamate can activate receptors coupled to heterotrimeric G-proteins, tremendous progress has been made in the field of metabotropic glutamate receptors. Now, eight members of this family of glutamate receptors, encoded by eight different genes that share distinctive structural features have been identified.
F. Ferraguti +2 more
openaire +3 more sources
Prospects for Metabotropic Glutamate 1 Receptor Antagonists in the Treatment of Neuropathic Pain
Journal of Medicinal Chemistry, 2007AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Jeffrey M, Schkeryantz +2 more
openaire +2 more sources
Activation of Metabotropic Glutamate Receptor 1 Dimers Requires Glutamate Binding in Both Subunits
The Journal of Pharmacology and Experimental Therapeutics, 2005Group I metabotropic glutamate receptors (mGluRs) form stable, disulfide-linked homodimers. Lack of a verifiably monomeric mGluR1 mutant has led to difficulty in assessing the role of dimerization in the molecular mechanism of mGluR1 activation.
Paul J, Kammermeier, June, Yun
openaire +2 more sources
Neuropharmacology, 1998
In this study we have addressed the identification of the metabotropic glutamate receptor (mGluR) involved in the facilitation of glutamate release in nerve terminals from the cerebral cortex. mGluR1 and 5 are coupled to phosphoinositide hydrolysis and the activation of these receptors with the specific agonist 3,5-dihydroxyphenylglycine (DHPG ...
A, Sistiaga +3 more
openaire +2 more sources
In this study we have addressed the identification of the metabotropic glutamate receptor (mGluR) involved in the facilitation of glutamate release in nerve terminals from the cerebral cortex. mGluR1 and 5 are coupled to phosphoinositide hydrolysis and the activation of these receptors with the specific agonist 3,5-dihydroxyphenylglycine (DHPG ...
A, Sistiaga +3 more
openaire +2 more sources
Heterologous expression of metabotropic glutamate receptor subtype 1 in Saccharomyces cerevisiae
Applied Microbiology and Biotechnology, 2004The upstream region of the isocitrate lyase gene (UPR-ICL) from the n-alkane-utilizing yeast Candida tropicalis serves as a useful promoter of gene expression in the yeast Saccharomyces cerevisiae. The production of rat metabotropic glutamate receptor 1alpha (mGluR1alpha), which belongs to the G-protein-coupled receptor (GPCR) family, was tested under ...
K, Sugiyama +5 more
openaire +2 more sources
Identification of the metabotropic glutamate receptor-1 protein in the rat trigeminal ganglion
Brain Research, 1993Anti-metabotropic glutamate receptor-1 monoclonal antibody was raised and applied for immunohistochemistry in the rat trigeminal ganglion. The antibody detected 145-kDa single band of protein in the immunoblot analysis. In immunohistochemistry, neurons in the trigeminal ganglion showed immunostaining with various intensity, almost irrespective of their
T, Araki +5 more
openaire +2 more sources
Competitive Antagonism by Phenylglycine Derivatives at Type 1 Metabotropic Glutamate Receptors
Molecular and Cellular Neuroscience, 1994Abstract The metabotropic glutamate receptors (mGluRs) form a family of G-protein-coupled receptors which consists of at least seven members termed mGluR1-mGluR7. These members are classified into subfamilies according to their sequence similarities, signal transduction mechanisms and agonist selectivities.
Ferraguti F. +5 more
openaire +2 more sources