Results 161 to 170 of about 54,745 (192)
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Atypical signaling of metabotropic glutamate receptor 1 in human melanoma cells
Biochemical Pharmacology, 2015The metabotropic glutamate 1 (mGlu1) receptor has emerged as a novel target for the treatment of metastatic melanoma and various other cancers. Our laboratory has demonstrated that a selective, non-competitive mGlu1 receptor antagonist slows human melanoma growth in vitro and in vivo.
Tara, Gelb +6 more
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Blockade of amygdala metabotropic glutamate receptor subtype 1 impairs fear extinction
Biochemical and Biophysical Research Communications, 2007The metabotropic glutamate receptor subtype 1 (mGluR1) is thought to be crucial for several forms of memory, but its role in memory extinction has not been determined. Here, we examined a role of mGluR1 in the extinction of conditioned fear using microinjection of an mGluR1 antagonist, CPCCOEt, into the lateral amygdala (LA), a critical structure for ...
Jeongyeon, Kim +7 more
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Metabotropic glutamate receptor 1 in human malignancies
2013The role of the glutamatergic system in cancer cell homeostasis has expanded exponentially over the last decade. Once thought to participate only in synaptic transmission and neuronal excitability, the presence of functional glutamate receptors has since been demonstrated in peripheral tissues. Most notable is the implication of glutamatergic signaling
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Subtype-Selective Noncompetitive Modulators of Metabotropic Glutamate Receptor Subtype 1 (mGluR1)
Current Topics in Medicinal Chemistry, 2005This article describes recent advances in the development of subtype-selective, noncompetitive modulators of metabotropic glutamate receptor subtype 1 (mGluR1). mGluR1 plays an important role in modulating synaptic transmission and neuronal excitability via intracellular signal transduction pathways and has been implicated in a number of CNS disorders.
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Journal of Neuroscience Methods, 2012
The availability of high quality, well-characterized antibodies for molecular and cellular neuroscience studies is important. However, not all available antibodies are rigorously evaluated, nor are limitations of particular antibodies often reported. We have examined a panel of currently available mGluR1 antibodies and have identified which ones are ...
Ramses, Ayala +5 more
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The availability of high quality, well-characterized antibodies for molecular and cellular neuroscience studies is important. However, not all available antibodies are rigorously evaluated, nor are limitations of particular antibodies often reported. We have examined a panel of currently available mGluR1 antibodies and have identified which ones are ...
Ramses, Ayala +5 more
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Journal of Molecular Medicine, 2004
Melanoma is the aberrant proliferation of melanocytes, the cells in the skin responsible for pigment production. In the United States the current lifetime risk of melanoma development is 1 in 57 in males and 1 in 81 in females. In its early stages melanoma can be surgically removed with great success; however, advanced stages of melanoma have a high ...
Yarí E, Marín, Suzie, Chen
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Melanoma is the aberrant proliferation of melanocytes, the cells in the skin responsible for pigment production. In the United States the current lifetime risk of melanoma development is 1 in 57 in males and 1 in 81 in females. In its early stages melanoma can be surgically removed with great success; however, advanced stages of melanoma have a high ...
Yarí E, Marín, Suzie, Chen
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Life Sciences, 1992
In established 8-12-day-old primary cultures of differentiated rat cerebellar granule neurons the level of metabotropic glutamate receptor 1 (mGluR1) mRNA and the sensitivity of cultures to the agonist-stimulated inositol phosphate (IP) formation was reversibly modified by changing the depolarizing properties of the medium, i.e.
M, Favaron, J M, Rimland, H, Manev
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In established 8-12-day-old primary cultures of differentiated rat cerebellar granule neurons the level of metabotropic glutamate receptor 1 (mGluR1) mRNA and the sensitivity of cultures to the agonist-stimulated inositol phosphate (IP) formation was reversibly modified by changing the depolarizing properties of the medium, i.e.
M, Favaron, J M, Rimland, H, Manev
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Cholesterol Dependence of the Conformational Changes in Metabotropic Glutamate Receptor 1
AbstractMetabotropic glutamate receptors (mGluRs) are class C G protein-coupled receptors that function as obligate dimers in regulating neurotransmission and synaptic plasticity in the central nervous system. The mGluR1 subtype has been shown to be modulated by the membrane lipid environment, particularly cholesterol, though the molecular mechanisms ...Ugochi H, Isu +5 more
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