Amino Acid Mutagenesis of the Ligand Binding Site and the Dimer Interface of the Metabotropic Glutamate Receptor 1 [PDF]
, 2003 Toshihiro Sato +4 more
openalex +1 more source
The dark sides of the GPCR tree ‐ research progress on understudied GPCRs
British Journal of Pharmacology, Volume 182, Issue 14, Page 3109-3134, July 2025.Abstract A large portion of the human GPCRome is still in the dark and understudied, consisting even of entire subfamilies of GPCRs such as odorant receptors, class A and C orphans, adhesion GPCRs, Frizzleds and taste receptors. However, it is undeniable that these GPCRs bring an untapped therapeutic potential that should be explored further.
Magdalena M. Scharf +10 more
wiley +1 more source
Role of G Protein-coupled Receptor Kinase 4 and ॆ-Arrestin 1 in Agonist-stimulated Metabotropic Glutamate Receptor 1 Internalization and Activation of Mitogen-activated Protein Kinases [PDF]
, 2003 Luisa Iacovelli +10 more
openalex +1 more source
G protein‐coupled receptor‐mediated autophagy in health and disease
British Journal of Pharmacology, Volume 182, Issue 14, Page 3151-3162, July 2025.G protein‐coupled receptors (GPCRs) constitute the largest and most diverse superfamily of mammalian transmembrane proteins. These receptors are involved in a wide range of physiological functions and are targets for more than a third of available drugs in the market. Autophagy is a cellular process involved in degrading damaged proteins and organelles
Devrim Öz‐Arslan +2 more
wiley +1 more source
Priming of Excitatory Synapses by α1Adrenoceptor-Mediated Inhibition of Group III Metabotropic Glutamate Receptors [PDF]
, 2003 Grant R. Gordon, Jaideep S. Bains
openalex +1 more source
ERNEST COST action overview on the (patho)physiology of GPCRs and orphan GPCRs in the nervous system
British Journal of Pharmacology, Volume 182, Issue 14, Page 3178-3210, July 2025.G protein‐coupled receptors (GPCRs) are a large family of cell surface receptors that play a critical role in nervous system function by transmitting signals between cells and their environment. They are involved in many, if not all, nervous system processes, and their dysfunction has been linked to various neurological disorders representing important
Necla Birgül Iyison +15 more
wiley +1 more source
Allosterism in the adenosine A2A and cannabinoid CB2 heteromer
British Journal of Pharmacology, Volume 182, Issue 14, Page 3371-3384, July 2025.Abstract Background and Purpose Allosterism is a regulatory mechanism for GPCRs that can be attained by ligand‐binding or protein–protein interactions with another GPCR. We have studied the influence of the dimer interface on the allosteric properties of the A2A receptor and CB2 receptor heteromer.
Claudia Llinas del Torrent +7 more
wiley +1 more source
The Neurotransmitter Glutamate Reduces Axonal Responsiveness to Multiple Repellents through the Activation of Metabotropic Glutamate Receptor 1 [PDF]
, 2004 Thomas A. Kreibich +2 more
openalex +1 more source
British Journal of Pharmacology, Volume 182, Issue 14, Page 3225-3248, July 2025.G protein‐coupled receptors (GPCRs) play a crucial role in cell function by transducing signals from the extracellular environment to the inside of the cell. They mediate the effects of various stimuli, including hormones, neurotransmitters, ions, photons, food tastants and odorants, and are renowned drug targets.
Małgorzata M. Kogut‐Günthel +11 more
wiley +1 more source