Results 171 to 180 of about 49,616 (199)

ATP and glutamate coordinate contractions in the freshwater sponge Ephydatia muelleri.

J Exp Biol
Ho VR, Goss GG, Leys SP.
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Metabotropic Glutamate 1 Receptor: Current Concepts and Perspectives

Pharmacological Reviews, 2008
Almost 25 years after the first report that glutamate can activate receptors coupled to heterotrimeric G-proteins, tremendous progress has been made in the field of metabotropic glutamate receptors. Now, eight members of this family of glutamate receptors, encoded by eight different genes that share distinctive structural features have been identified.
F. Ferraguti, L. Crepaldi, NICOLETTI, Ferdinando   +2 more
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Prospects for Metabotropic Glutamate 1 Receptor Antagonists in the Treatment of Neuropathic Pain

Journal of Medicinal Chemistry, 2007
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
and Ann E. Kingston, Michael P. Johnson, Jeffrey M. Schkeryantz   +2 more
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Heterologous expression of metabotropic glutamate receptor subtype 1 in Saccharomyces cerevisiae

Applied Microbiology and Biotechnology, 2004
The upstream region of the isocitrate lyase gene (UPR-ICL) from the n-alkane-utilizing yeast Candida tropicalis serves as a useful promoter of gene expression in the yeast Saccharomyces cerevisiae. The production of rat metabotropic glutamate receptor 1alpha (mGluR1alpha), which belongs to the G-protein-coupled receptor (GPCR) family, was tested under ...
K. Sugiyama, T. P. Niki, Atsuo Tanaka, Atsuo Tanaka, Y. Teranishi, Mitsuyoshi Ueda, Kaoru Inokuchi   +6 more
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Identification of the metabotropic glutamate receptor-1 protein in the rat trigeminal ganglion

Brain Research, 1993
Anti-metabotropic glutamate receptor-1 monoclonal antibody was raised and applied for immunohistochemistry in the rat trigeminal ganglion. The antibody detected 145-kDa single band of protein in the immunoblot analysis. In immunohistochemistry, neurons in the trigeminal ganglion showed immunostaining with various intensity, almost irrespective of their
Ryoichi Yoshimura, Hiroyuki Sugiyama, Atsushi Nishimune, James G. Kenimer, Toshiyuki Araki, Hiroshi Kiyama   +5 more
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Atypical signaling of metabotropic glutamate receptor 1 in human melanoma cells

Biochemical Pharmacology, 2015
The metabotropic glutamate 1 (mGlu1) receptor has emerged as a novel target for the treatment of metastatic melanoma and various other cancers. Our laboratory has demonstrated that a selective, non-competitive mGlu1 receptor antagonist slows human melanoma growth in vitro and in vivo.
Sergey Pshenichkin, Carrie Bowman Dalley, Hannah A. Hathaway, Barry B. Wolfe, Tara Gelb, Jarda T. Wroblewski, Ewa Grajkowska   +6 more
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Involvement of metabotropic glutamate receptor�1, a G protein coupled receptor, in melanoma development [PDF]

Journal of Molecular Medicine, 2004
Melanoma is the aberrant proliferation of melanocytes, the cells in the skin responsible for pigment production. In the United States the current lifetime risk of melanoma development is 1 in 57 in males and 1 in 81 in females. In its early stages melanoma can be surgically removed with great success; however, advanced stages of melanoma have a high ...
Yarí E. Marín, Suzie Chen
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Competitive Antagonism by Phenylglycine Derivatives at Type 1 Metabotropic Glutamate Receptors

Molecular and Cellular Neuroscience, 1994
Abstract The metabotropic glutamate receptors (mGluRs) form a family of G-protein-coupled receptors which consists of at least seven members termed mGluR1-mGluR7. These members are classified into subfamilies according to their sequence similarities, signal transduction mechanisms and agonist selectivities.
Ferraguti F., Cavanni P., Eistetter H., Salvagno C., Ratti E., Trist D. G.   +5 more
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